DRSC/TRiP Functional Genomics Resources

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Protein Alignment Muc14A and Akap13

DIOPT Version :9

Sequence 1:NP_727928.3 Gene:Muc14A / 318097 FlyBaseID:FBgn0052580 Length:16223 Species:Drosophila melanogaster
Sequence 2:XP_036009413.1 Gene:Akap13 / 75547 MGIID:2676556 Length:2817 Species:Mus musculus


Alignment Length:3328 Identity:627/3328 - (18%)
Similarity:1134/3328 - (34%) Gaps:908/3328 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  3235 LPISVPQSSTTANRLLTGSIAEEQTAQEE----------TSEHSKSLPQLTTEESSSFQESSAEE 3289
            :.:|..|:....:.::|..:|||...:::          |..|..|    |.:.||...|:.|..
Mouse     1 MKLSPQQAPLYGDCVVTVLLAEEDKVEDDAIFYLIFSGSTLYHCTS----TRKVSSDTLETIAPG 61

  Fly  3290 HQTTEVPWTLSTSLSQSSSEAKNIFSSQSVNEDNISQEDTRTPSISVPQSSTTANRLLTGSSAEE 3354
            |...|   |:...|. :|.|...:|.        :::||..    .|...:..|.:.| .:||..
Mouse    62 HDCCE---TVKVLLC-ASREGLPVFV--------VAEEDFH----FVQDEAYDAAQFL-ATSAGN 109

  Fly  3355 PTAQEETSELSKSLPQLTAEESSSFQESSAEENQMTEVP--W-TLSTSLSQSSSKTKNIFSSQSV 3416
            ..|...|..|.:|.|  .:.:.:|..|..|...:..::|  | .|.|..:......:......:|
Mouse   110 QQALNFTRFLDRSGP--PSRDVNSLDEKVALAFRHLKLPAEWNVLGTDHTLHDGGPRETLMHFAV 172

  Fly  3417 NED------------------NISQEDTRTP-SISVPQSSTTANRLLTGSSAEEPTAQEETSELS 3462
            ...                  :|..::..|| |:::.:.....::|||..:|.||   :..|.||
Mouse   173 RLGLLRLTWFLLQKPGGRGALSIHNKEGATPVSLALERGYHELHQLLTEENAGEP---DSWSSLS 234

  Fly  3463 KSLP--------------QLTTEESSSFQESSAEENQMTEVPWTLSTSLSQSSSKTKNIFSSQSV 3513
            ..:|              ...|.||.|.:|...:             |.:...||..||  .|.:
Mouse   235 YEIPYGDCSVRHHRELDIYTLTSESESHREPHGD-------------SCTGHISKLMNI--QQQL 284

  Fly  3514 NEDNISQEDTRTPSISVPQSSTTANRLLTGSGAEEPTAQEETSELSKSLPQLTTEESSSFQESSA 3578
            .:.|:.|.|...|.:...|.|:..           |:..|........:|:.:..:...|:|:.:
Mouse   285 MKTNLKQMDNLMPLMVTAQDSSCV-----------PSVPETDGLFLPCVPEPSDHQHPPFEETKS 338

  Fly  3579 ------EENQMTEVPWTLSTSLSQSSSEAKNIFSSQSVNDDKTSQEDTRTPSISVPQSSTT---- 3633
                  ...:|.|....||     |..|.:|:..|...|.|...:.:...|:.::...|.:    
Mouse   339 TLCCQRSPGRMAESSCDLS-----SMVEEENVICSHKKNKDVGRKGEEAEPASAMDSGSASHQDS 398

  Fly  3634 -------------------ANR-LLTGSS-AEEPTAQEETSEHSKSLPQLTTEESSSFQESSAEE 3677
                               .|| .:||:: :...|.|:..|..|..|......|..:.|.||.. 
Mouse   399 CLQSVPDCGVKGREGLPSCGNRNEVTGTNYSGVATCQQPLSSRSSVLQDAMVTEPDACQHSSGR- 462

  Fly  3678 HQTTEVPWTLST---SPSQSSSKTKNIFSSQSVNEDKISQ--EDTRTLSISVSQSSTTANRLLTG 3737
                |:|.:.||   :|.::.....::.:..:..::...|  |.|:. .:..|.||||       
Mouse   463 ----ELPDSSSTDVGAPEKAGELEHSLLTPDATTQNNKPQVGEGTKE-RLENSDSSTT------- 515

  Fly  3738 SIAEEQTAQEETSELSKSLPQLTTEESSSFQKSSAEENQMTEVPWTLSTSLSQSSSEAKNIFSSQ 3802
                |.||.:..||                   ..|:..:|...:..|.....:.:||....||:
Mouse   516 ----ETTAVQVLSE-------------------PMEKADITNHVFATSAVGVNTPAEASPALSSE 557

  Fly  3803 SVNDDKTSQE---------DTRTPSISVPQSSTTANSLLTGSSAEEQTAQ--EETSELSKSLPQL 3856
            .:..:|...|         .|...|..|..::...|.:|.|...:...|.  :..|.|..::|  
Mouse   558 EIPTEKPGMETQERGCEGGTTSDQSSPVLPAAAIENKVLGGQEPDTSIAGFCKTASPLDLTMP-- 620

  Fly  3857 TTEESSSFQKSSAEEHQTTEVPWTLSTSPSQSSSKTKNIFSSQSVNEDKISQEDTRTLSISVSQS 3921
             ...|....:.::|.|          ..|:||.|....:.|:......  |.|.|...|     :
Mouse   621 -GPSSDGMPEQNSESH----------ARPAQSLSGQALLCSTAEAGTP--SAEATHQPS-----T 667

  Fly  3922 STTANRLLTGSIAEEQTAQEETSELSKSLPQLTTEESSSFQKSSAEENQMTEVPWTLSTSLSQSS 3986
            .|::.||            ||......|||     ||:..|.|:.|          |.|:|....
Mouse   668 VTSSGRL------------EECGSGKASLP-----ESTMVQPSTQE----------LCTTLCPED 705

  Fly  3987 SEAKNIFSSQIVNEDKT------SQEDTRTPSISVPQSSTTANSL-------LTGSSAEEQTAQE 4038
            .:|..:.|..:.|..|:      ...|.:.....:.|.:...|.|       ...|..|::.|.:
Mouse   706 PQADTVTSDTVKNTQKSVGVCHLCVSDAKNQGNGLKQDTPLTNVLEDVPRLPSVVSQTEKELAPD 770

  Fly  4039 ETSELSKSLPQLTTEESSSFQKSSA------EENQMTEVPWTVSTSLSQSSSKTKNIFSSQSVNE 4097
            :.|..:.|....::.||.|..|..|      ::.:.|..|....|:..:.....:::..:..|.:
Mouse   771 QVSPPASSFSLASSPESESVTKDDALSLVPSQKEKGTATPQLHRTTACRDGPDGRDLSDTDKVGD 835

  Fly  4098 DKTSQEDTRTLSISVPQSIATANSLLTGSSAEEQ----TAQEETSEDSK-------------SLP 4145
            ..|....    |.:|....:..|:...|...|::    ||..|...||.             :||
Mouse   836 GATDPPP----SSAVELRTSMGNTSPVGIGGEQEGSSPTATLEVLSDSLLHNVDKAALVSDFTLP 896

  Fly  4146 QLTTEESSSFQESSAEENQTTEVPWTLSTSLSQSSSKTKNIFSSQSVNED----NISQEDTRTPS 4206
                           ||..:..||.: ||:|.|...  ....|..||.||    .:|:||.||| 
Mouse   897 ---------------EEGVSVVVPES-STALGQDGK--DRAMSCSSVKEDVHSSEMSREDQRTP- 942

  Fly  4207 ISVPQSSTTANRLLTGSSAEEPTAQEETSELSKSLPQLTTEESSSFQKSSAEENQMTEVPWTLST 4271
                                 |:.||......|.:..|..||.:.....||          .|.|
Mouse   943 ---------------------PSGQEIPGLCEKPMSALCAEEKAQQHTPSA----------CLKT 976

  Fly  4272 SLSQSSSEAKNIFSSQIVNEDKTSQEDTRTPSISVPQSSTTANSLLTGSSAEEQTAQEETSELSK 4336
                   |.|:|  .::..:.....|.....|:..|::|.:|:|....||.|    |..:|.|..
Mouse   977 -------ETKDI--KEVAPQVSLLTEGGAAKSLVPPRTSLSADSKQKASSTE----QSGSSLLPS 1028

  Fly  4337 SLPQLTTEESSSFQESSAEENQTTEVPWTVLTSLSQSSSKTKNIFSSQSVNEDKTSQEDTRTLPI 4401
            .||  ...|:....:.||.:         |:...:|...:|.....|:|..||.|          
Mouse  1029 GLP--GASEALHCNQPSALD---------VVVENTQFQGETNACEVSRSAMEDVT---------- 1072

  Fly  4402 SVPQSIATANSLLTGSSAEEQTAQEETSELSKSLPQLTTEESSSFQESSAEENQMTEVPWTVSTS 4466
                 :|.|      |.|..:..:::.|...|.:|         ..|...:|.|||       .|
Mouse  1073 -----VADA------SPATAEPRKKDASHCIKDIP---------ISELLNQEKQMT-------PS 1110

  Fly  4467 LSQSRSKTKNIFSSQSVNEDKTSQEDTRTLSI-SVPQSIATANSLLTGSS------AEEQTAQEE 4524
            |.:: ...|.:...|.|...:....|.:..:: ....:.||:||..|...      |.:...:..
Mouse  1111 LPEA-FLDKGVTDLQEVITPEIEPLDCKRETLEGTDLNCATSNSKETPIEKPMQPLARDLPTETG 1174

  Fly  4525 TSELSKSLPQL----TTEESSSFQESSAE--ENQMTEVPWTVSTSLSQSRSK-TKNIFSSQSVNE 4582
            .|.::.::||.    ..:.|...:||:|.  ..|..:|| |.:.|:.::.:: .:.:......:.
Mouse  1175 LSVINNNVPQADMKQVAQASIPAEESNATTVSTQAADVP-TRADSIEETATRIVEAVIRQVRASN 1238

  Fly  4583 DKTSQEDTRTPSISVPQS-------IATANSLLTGSSAE-EQTAQEETSELSKSLPQLTREESSS 4639
            ...::.:|:.||:|.|::       ..:|.:.|.|.:.: |:|.::.|.:....    |.|....
Mouse  1239 ALMAKVETQNPSLSSPETKQLENAYTESACAFLPGETPQIEKTHEDTTGQCGAE----TEEPEKI 1299

  Fly  4640 FQKSSAEEHQTT----EVPWTLSISLSQSSLQAKNIFSSPSLNEDNISQED--TRTLPISVPQSI 4698
            ....||.|...|    ||.....||.:.......|..::|.:.:...:|.:  ||.:|       
Mouse  1300 ILPESAPEMPDTRTGDEVDLLSRISAASEEEAVGNGAATPKMKQGPGTQANDCTRVIP------- 1357

  Fly  4699 ATAHSLLTGSSAEEQTAQEETSEHSKSLPQLTTE---------ESSSFLESSAEENQTTEVPWTL 4754
                           :..||.::.:||.|::..|         |::|.|.|.......:.:...|
Mouse  1358 ---------------SCCEEKNQRNKSSPKINRESWCAIEPCPEAASLLASKQSSECRSFIDVGL 1407

  Fly  4755 STSPSQSSSKTKNIFSSQS-VNEDKTSQEDTRTLPISVPQSIA--TTNSLLTGSSAEEQTAQEET 4816
            .|..:......:.:..|:| :....:.:.|:...|....:.:.  ||.|   .||.::..:.:..
Mouse  1408 GTECASKEGMLQRVSGSESDLFHSPSDEMDSIIFPKPEEEQLLCDTTGS---SSSTDDTASLDRH 1469

  Fly  4817 SEHSK--SLPQLT-----------------------TEESSSFLESSAEENQ-----TTEVPWTL 4851
            |.|..  ||||.:                       :.||.|....|.|..:     .||||  .
Mouse  1470 SSHGSDVSLPQTSKLNRSRNHQSANGFFSPGVEAPESRESESEPAGSGEMEEEEMDSITEVP--A 1532

  Fly  4852 STSLSQSSLQA------------KNIFSSPSLNEDN-------------ISQEDTRTLPISVPQS 4891
            :.|..:||:::            ||..|...:|:.:             |.:......|..|..|
Mouse  1533 NCSFLRSSMRSLSPFRRHSWGPGKNAASDAEMNQRSSMRALGHVVRRPPIHRRSMSWCPSGVQYS 1597

  Fly  4892 IA-TANSLLTGSSAEEQTAQEETSEHSKSLPQLTTEESSSFQESSAEENQTTEVPWTLSTSLSQS 4955
            .| .|:..:...|.|..|.....::.|.|| ::::..||..:.....|.|...:.......|...
Mouse  1598 AALNADFNIRSFSLEGLTGGGVGNKPSSSL-EMSSANSSELRNPFGGEEQRNSLMSLSEEHLEPD 1661

  Fly  4956 SSQAKNIFSSQSLNEDKTSQEDTRTPSISVPQSIATAHSLLTGSSAEEQTAQEETSEHSKSLPQL 5020
            ..|...:|..|:....|....:..|.:||.|  :..:.||:|.|.....:::...|. |.:|.:.
Mouse  1662 QRQHHRMFDQQTCYRSKQQGFNYCTSAISSP--LTKSISLMTISHPGLDSSRPFHST-SANLTES 1723

  Fly  5021 TTEESSSFLESSA-----EENQTTEVPWTLS------TSPSQSSSKTKNIFSSQSVNED-KTSQE 5073
            .|||:.:||..|.     ||...|:|..|.|      :|..:|..|.|.....:...:| |..::
Mouse  1724 ITEENCNFLPPSPSKKNFEEKSGTKVSRTFSYIRNKMSSSKKSKEKEKEKDKIKEKEKDSKEKEK 1788

  Fly  5074 DTRTL------PISVPQSIATTNSLLTGSSAEEQT-------AQEETSEHSKSLPQLTTEESSSF 5125
            |.:||      ||.:...|:.:..:...::.:..|       ..:...|:..|..::..::....
Mouse  1789 DKKTLNGHTFSPIPIVGPISCSQCMKPFTNKDAYTCAGCGAFVHKGCRENLASCAKVKMKQPKGS 1853

  Fly  5126 LESSAEENQTTEVPWTLSTSPSQ---SSSKTKNIFSSQSVNEDKTSQEDTRTLPISVPQSIATAN 5187
            |::....:..|.:....|:.|.:   |:....:..::..:..::.||:.     :|:.:|::..|
Mouse  1854 LQAHDTSSLPTVIMRNKSSQPKERPRSAVLLADEATAAPMFTNRRSQQS-----VSLSKSVSIQN 1913

  Fly  5188 SLLTGSSAEEQTAQ------------EETSKHSKSLPQLTTE-------ESSSFQESSAEENQTT 5233
              :||...:|..:.            .:..|.::|...||.|       |.....:..::..|..
Mouse  1914 --ITGVGNDENMSNTWKFLSHSTDSLNKICKVNESTESLTDEGVGTDMNEGQLMGDFESDSKQLE 1976

  Fly  5234 EVPWTLSTSPSQSSSKTKNIFSSQSVNED--KTSQEDTRTLPISVPQSIATTNSLLTGSSAEEQT 5296
            ...|:.:........:.|::...|.|..:  :|.....|||.|   .|...:..::|....|:|.
Mouse  1977 AESWSRTVDSKFLKQQKKDVVKRQEVIYELMQTELHHIRTLKI---MSDVYSRGMMTDLLFEQQM 2038

  Fly  5297 AQ-------EETSEHSKSLPQLTTEESSSFLESSAEENQTTEVPWTLSTSLSQSSLQAKNIFSSP 5354
            .:       |..|.||:...::...:..|.::.| |:|                       |...
Mouse  2039 VEKLFPCLDELISIHSQFFQRILERKKESLVDKS-EKN-----------------------FLIK 2079

  Fly  5355 SLNEDNISQEDTRTLPISVPQSIATANSLLTGSSAE--EQTAQEETSEHSKSL---PQLTTEESS 5414
            .:.:..:||                    .:|.|||  ::|..:...:|::|:   ..|.|:: .
Mouse  2080 RIGDVLVSQ--------------------FSGESAERLKKTYGKFCGQHNQSVNYFKDLYTKD-K 2123

  Fly  5415 SFQESSAEENQTTEVPWTLSTS-----LSQSSSQAKNIFSS--QSLNEDNISQEDTRTPSIS-VP 5471
            .|| :..::..::.|...|...     ::|..::...:|..  |...::.:.|||. |.|:| |.
Mouse  2124 RFQ-AFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDL-TQSLSLVK 2186

  Fly  5472 QSIATANSLLTGSSAEEQTAQEETSEHSKSLPQLTT---------------EESSSFQKSSAEEN 5521
            ..|...:|.:.....:.:..:..|...|||:.::.:               .:.|.|.||:.  .
Mouse  2187 DVIGAVDSKVASYEKKVRLGEIYTKTDSKSIMRMKSGQMFAKEDLRRKKLVRDGSVFLKSTT--G 2249

  Fly  5522 QMTEVPWTLSTSL---SQSSSQAKNIFSSQSLNEDNISQEDTRTPSISVPQSIATANSLLTGSSA 5583
            ::.||...|.|.:   .|...| |.:|:|.          |.::..||:.:.|.           
Mouse  2250 RLKEVQAVLLTDILVFLQEKDQ-KYVFASL----------DHKSTVISLKKLIV----------- 2292

  Fly  5584 EEQTAQEETSEHSKSL----PQLTTEESSSFQESSAEENQTTEVPW------TLST--------S 5630
             .:.|.||......|:    |::....:||.:|.::         |      |:::        .
Mouse  2293 -REVAHEEKGLFLISMGVKDPEMVEVHASSREERNS---------WIQIIQDTINSLNRDEDEGI 2347

  Fly  5631 PSQSSSKTKNIFSSQSVNEDKTSQEDTRTLPISVPQSIATTNSLLTGSSAEEQTAQEETSEHSKP 5695
            ||::..:.|.:.:.....:::..|:|.:.|             ||.   .|::....:.:|.|.|
Mouse  2348 PSENEEEKKLLDTKARELKEQLQQKDQQIL-------------LLL---EEKEMIFRDMTECSTP 2396

  Fly  5696 LPQLTTEESSSFLESSAEENQTTEVPWTLSTSLSQSSLQGKNIFSSPSLNEDNISQ--------- 5751
            ||               |:...|..|..|..|.::.:|:|..:..| ::||..|.|         
Mouse  2397 LP---------------EDCSPTHSPRVLFRSNTEEALKGGPLMKS-AINEVEILQSLVSGSLGG 2445

  Fly  5752 -----------EDTRTLPISVPQSIAT--------ANSLLTGSSAEEQTAQEETSEHSKSLPQLT 5797
                       ::....|||:|:...|        .|:...|...|....|:           |.
Mouse  2446 TLGQSISSPVEQEVMAAPISLPRRAETFGGFDCHQMNASKGGEKEEGDDGQD-----------LR 2499

  Fly  5798 TEESSSFQESSAEENQMTEVPWTLSTSLSQSSSKTKNIFSSQSVNEDKTSQEDTRTLSISVPQSI 5862
            ..||.|..:.....|    :.:.|..:..|......::....|:.:....|:|    |....|.:
Mouse  2500 RTESDSGLKKGGNGN----LVFMLKRNSEQVVQSIVHLHELLSMLQGVVLQQD----SYIEDQKL 2556

  Fly  5863 ATANSLLTGSSAEEQTAQEETSEDSKSLPQLTTEESSSFQKSSA---EENQMTEVPWTLSTSLSQ 5924
            .....:||.|::...:..|:  |..:|| :...::.::.||..|   ||.:..|..|        
Mouse  2557 VLTEKVLTRSASRPSSLIEQ--EKQRSL-EKQRQDLANLQKQQAQHLEEKRRREREW-------- 2610

  Fly  5925 SSSQAKNIFSSPSSNEDNISQEDTRTLPISVPQSIATANSLLTGSSAEEQTAQEETSEHSKSLPQ 5989
                        .:.|..:...:.:.                    ||    :|||....:    
Mouse  2611 ------------EAREQELRDREAKL--------------------AE----REETVRRRQ---- 2635

  Fly  5990 LTTEESSSFQESSAEENQMTEVPWTVLTSLSQSSSITKNIFSSQSVNEDKTSQEDTRTLSISVPQ 6054
                     |:...:..::.:...|....|.:..:..|     |...|.:..:.||..||     
Mouse  2636 ---------QDLERDREELQQKKGTYQCDLERLRAAQK-----QLEREQEQLRRDTERLS----- 2681

  Fly  6055 SIATANSLLTGSSAEEQTAQEETSELSNS----------LP---QLTTEESSSFQKSSAEENQMT 6106
                           ::...:...::||.          ||   :.::..:.|..||.:.:::::
Mouse  2682 ---------------QRQMDQNLCQVSNKHGRLMRIPSFLPNSDEFSSPSAPSVTKSGSLDSELS 2731

  Fly  6107 EVPWTLSTSLSQSSSQAKNIFSSQSLNEDNISQEDTRTP--SISVPQSIATANSLLTGSSAEEQT 6169
            ..|...|.|.:|......:|..|.|         .|:.|  ....|.|.:|:..|...|..:|:.
Mouse  2732 VSPKRNSISRTQKDKGPFHILGSAS---------QTKVPEGQSQAPSSTSTSTRLFGLSKPKEKK 2787

  Fly  6170 AQEETSEHSKSLP 6182
            .:::.|:.|::.|
Mouse  2788 EKKKKSKGSRTQP 2800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc14ANP_727928.3 PRK14949 <11377..11776 CDD:237863
PRK08581 11922..>12215 CDD:236304
PRK14949 <13679..14114 CDD:237863
PRK14949 <14663..15055 CDD:237863
Akap13XP_036009413.1 opacity_OapA <1150..>1298 CDD:411470 30/152 (20%)
C1_AKAP13 1792..1848 CDD:410428 8/55 (15%)
RhoGEF 1999..2193 CDD:238091 46/243 (19%)
PH_AKAP13 2236..2338 CDD:275427 27/135 (20%)
SMC_prok_B <2519..2674 CDD:274008 33/223 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 1.056642 Normalized mean entropy S9998
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.950

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