DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc14A and ZAN

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_003377.2	Gene:	ZAN / 7455	HGNCID:	12857	Length:	2812	Species:	Homo sapiens

Alignment Length:	638	Identity:	147/638 - (23%)
Similarity:	236/638 - (36%)	Gaps:	153/638 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly 14729 KSLPQLTTAESISFQESSAEQNQMTEEPWTLSTSLPQTS-SKTNITFSSQSVYEDKTSLEDTRTL 14792
            |.||:|.....:| ....:|...:||.| |:||..|..| .|.::|....:|.::|.::.
Human   537 KVLPELPPVSPVS-STGPSETTGLTENP-TISTKKPTVSIEKPSVTTEKPTVPKEKPTIP----- 594

  Fly 14793 SISQSITMTNSPLTDLSAEDQTNQEETSELSKSLPQLTTEESISFQES---SAEQNQMTEEPWTL 14854
                    |..|  .:|.|..|...|...:....|.:.:|:.....|.   .:|:..:..|..|:
Human   595 --------TEKP--TISTEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKPTIPSEKPTI 649

  Fly 14855 STSLPQTSSKTNITFSSQSVNEDKTSLEDTRTLSISQSITMTNSLLTDLSAEDQTNQEETSELSK 14919
            ||..|...::           |..|..|:|.|                 |.|:.....|...:..
Human   650 STEKPTVPTE-----------EPTTPTEETTT-----------------SMEEPVIPTEKPSIPT 686

  Fly 14920 SLPQLTTEE-SISFQES--SAEQNQMTEEPWTLSTSLPQSSSKTNNIFSSQ--SVNEDKTSLEDT 14979
            ..|.:.||: :||.:|:  |.|:..::.|..|:.|..|...::.:.|...:  :..|..|...:.
Human   687 EKPSIPTEKPTISMEETIISTEKPTISPEKPTIPTEKPTIPTEKSTISPEKPTTPTEKPTIPTEK 751

  Fly 14980 RTLSTSQPITITNSPLTDLSAEDQTNQEETSVLSKSLPQLTTEE-SISFQESSAEQNQMTEEPWT 15043
            .|:|..:|.|.|..|  .:|.|..|...|...:....|.:.||: :||.:|.:..    |||. |
Human   752 PTISPEKPTTPTEKP--TISPEKLTIPTEKPTIPTEKPTIPTEKPTISTEEPTTP----TEET-T 809

  Fly 15044 LSTSPPQSSSKTKNIFSSQSVNEEKTSL--EDTRTLSISQSRAITNSLLTDLSAEDQTNKEEISE 15106
            :||..|             |:..||.:|  |:| |.|:.:         |.:|.|..|...|...
Human   810 ISTEKP-------------SIPMEKPTLPTEET-TTSVEE---------TTISTEKLTIPMEKPT 851

  Fly 15107 LSKSLPQLTTEESISFQESSAEQNQMTEEPWTLSTSPP-----QSSSNTIKTTETSEEPLCLCTC 15166
            :|...|.:.||:    ...|.|:..:..|..|:.|..|     :::.:|.|.|..:|:|
Human   852 ISTEKPTIPTEK----PTISPEKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEKP------ 906

  Fly 15167 VIDPDEDICSCNCKITKSIPTGRTTSKHSQWDGSSTKALGLDGTEDQKTFDATQNSMTIGLLSKE 15231
            .|.|::...|..   ..:|||.:.|.
Human   907 TISPEKPTISTE---KPTIPTEKPTI--------------------------------------- 929

  Fly 15232 PTQTLTFSKLSTTQIITEKSTSNNLSVHSNIDKSTISTQ-PYFDTDTTKYSTSVGVLSEESSKLT 15295
            ||:..|.|....| |.|||.|.:...:....:|.||||: |...|:.....|....:..|...:.
Human   930 PTEETTISTEKLT-IPTEKPTISPEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIP 993

  Fly 15296 KQNITEEITTNILSLPSNIAT--STTLTQPHS-DTDKTEAIQNQTTAGHTTQD 15345
                ||::|......||..||  :..:..||: .|..|..|...||...::.:
Human   994 ----TEKLTALRPPHPSPTATGLAALVMSPHAPSTPMTSVILGTTTTSRSSTE 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863	79/335 (24%)
ZAN	NP_003377.2	MAM	41..203	CDD:306977
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..84
		MAM	211..367	CDD:306977
		MAM	373..535	CDD:306977
		Atrophin-1	<540..1022	CDD:331285	140/613 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..884		97/417 (23%)
		66 X heptapeptide repeats (approximate) (mucin-like domain)	573..1041		134/597 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	904..929		8/33 (24%)
		TIL	1044..1093	CDD:307783
		TILa	1095..1148	CDD:315397
		VWD	1156..1308	CDD:306577
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1302..1323
		C8	1349..1423	CDD:214843
		TIL	1426..1479	CDD:307783
		TILa	1481..1535	CDD:315397
		VWD	1542..1695	CDD:306577
		C8	1742..1808	CDD:312319
		TILa	1869..1924	CDD:315397
		VWD	1931..2084	CDD:306577
		C8	2149..2207	CDD:312319
		TIL	2211..2267	CDD:307783
		TILa	2269..2320	CDD:315397
		VWD	2331..2484	CDD:306577
		C8	2543..>2597	CDD:214843
		TILa	2654..2707	CDD:315397
		EGF	2712..2740	CDD:306513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900