DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc14A and VWF

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_000543.3	Gene:	VWF / 7450	HGNCID:	12726	Length:	2813	Species:	Homo sapiens

Alignment Length:	1448	Identity:	241/1448 - (16%)
Similarity:	393/1448 - (27%)	Gaps:	653/1448 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 ELFDNLDHLENNR--KLNFASQEVLEIHNQANFKDKHIYVWKNLTRYISNDNNLNHTVTKVNISD 287
            ::|..:|..|.:|  .|..||||...:.             :|..||:.........|..|.|..
Human  1367 QIFSKIDRPEASRITLLLMASQEPQRMS-------------RNFVRYVQGLKKKKVIVIPVGIGP 1418

  Fly   288 YQS------------KNK----KSINPIE-----------DILPS--PFTKTYNLGRFARNQGLL 323
            :.:            :||    .|::.:|           |:.|.  |.|...::.:.....|||
Human  1419 HANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLL 1483

  Fly   324 QM------EKTPIIRAKINLSSSDSTSTCEL--CSETLDETTN---------------------- 358
            .:      ..:.::.....|..||.....:.  ..|.::|...
Human  1484 GVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTV 1548

  Fly   359 --PFDSAETCEECVSLASNIFEEYTE------------------SNDEFLSSSSEEACEECSDIV 403
              ||..|::       ..:|.:...|                  |:..||.|..:.  |:..::|
Human  1549 EYPFSEAQS-------KGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDR--EQAPNLV 1604

  Fly   404 -----SP-SASIK--------YPISIYNTTTMGSTILERTIIIFGYFTEIITMIIFEFETI---- 450
                 :| |..||        .||.:.....:..  |||    .|:....|  :|.:|||:
Human  1605 YMVTGNPASDEIKRLPGDIQVVPIGVGPNANVQE--LER----IGWPNAPI--LIQDFETLPREA 1661

  Fly   451 -----------------TFSDAPEPNSDITGYTSTECIKCSELTTTVPIETTIERTKLSETPLQK 498
                             |.|.||:               ||:     |::..:.....|..|..
Human  1662 PDLVLQRCCSGEGLQIPTLSPAPD---------------CSQ-----PLDVILLLDGSSSFPAS- 1705

  Fly   499 LQFSTPKKSTNRF------------ASVLQLNAVT--DSSIKVLNTKTDQFDTEEETSLSEFLPE 549
             .|...|.....|            .||||..::|  |....|:..|....      ||.:.:..
Human  1706 -YFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLL------SLVDVMQR 1763

  Fly   550 --WPTVLGSSLQFS----TIETQPSTNNGQLTHTEKTTLSKSI---------------------N 587
              .|:.:|.:|.|:    |.|          .|..:...||::                     |
Human  1764 EGGPSQIGDALGFAVRYLTSE----------MHGARPGASKAVVILVTDVSVDSVDAAADAARSN 1818

  Fly   588 HIKHHKINLGQNAEAASHFNIQPGALHTISTTGGYHPTVKKKQSETLPLLST--KSISLNMCDCT 650
            .:....|.:|...:||.        |..::...|....||.::.|.||.:.|  .|....:|...
Human  1819 RVTVFPIGIGDRYDAAQ--------LRILAGPAGDSNVVKLQRIEDLPTMVTLGNSFLHKLCSGF 1875

  Fly   651 CKLEIAKDSCICECNLKKSTSDISKGVTASASNQSLPTETNRKLHSMKDYAPNGTSLLTNASPEP 715
            .::      |:.|...:|...|:          .:||.:    .|:: ...|:|.:||.
Human  1876 VRI------CMDEDGNEKRPGDV----------WTLPDQ----CHTV-TCQPDGQTLLK------ 1913

  Fly   716 FTIDDVTYKGNL-AGKKTTMPSELSSLKKIEPVKTHDVCECTCLLEQGNDSCTCNC-------MT 772
                  :::.|. .|.:.:.|:..|      |||..:.|.|..       :|.|.|       :.
Human  1914 ------SHRVNCDRGLRPSCPNSQS------PVKVEETCGCRW-------TCPCVCTGSSTRHIV 1959

  Fly   773 DFISTSIQISSTGPDQISQNKMGNQSQSVPL-----------------------LNTEFSDLMKI 814
            .|...:.:::.:....:.|||  .|...|.|                       |:.|....|::
Human  1960 TFDGQNFKLTGSCSYVLFQNK--EQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEV 2022

  Fly   815 STTYK-------------------MHQT-------------QNDIEKLSKSPPVLSTTSSGL--- 844
            :...:                   ||:.             ||:..:|..||...::.:.||
Human  2023 TVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGI 2087

  Fly   845 ------------------------PKWPTTR---TLEKKKQQSKSLPSLS--------------- 867
                                    .:|...|   |.:...::...:|..|
Human  2088 CDENGANDFMLRDGTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHK 2152

  Fly   868 -----------------------TISNF-HFEKSN-------------------------FHGC- 882
                                   .|::: |..::|                         .|||
Human  2153 VLAPATFYAICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCP 2217

  Fly   883 ----------------DCTC-----QLE------------LGRDS---------------C-ICE 898
                            .|.|     .||            :|.|.               | ||.
Human  2218 RHCDGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICT 2282

  Fly   899 CNFKESTSDVSTSRSNQPLPT---------KLHSVKDNA---------------------PH--- 930
            |     .|....:.:.||.||         ::..::.||                     ||
Human  2283 C-----LSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHCER 2342

  Fly   931 ----SLTN-------------------ANPESLTSKDLTT------------KGNGVTDNKITTL 960
                :|||                   .:|.|.....|.|            ..|.|.......|
Human  2343 GLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVNSTVSCPL 2407

  Fly   961 SKLSS--DNVCEC---TCL-----------------LEQGNDSCTCNCMTDTNSIDESILTASQI 1003
            ..|:|  .|.|.|   |||                 .|:|.|.|||..|.|.            :
Human  2408 GYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDA------------V 2460

  Fly  1004 VSSEDLQYSSNP--PSYKSTQENTNTKGK--NKNLSTLLQI---SSTGPYQIYQSEIGNQSQYVP 1061
            :.....|.|..|  .|.:|.......:|:  .:.|.:..::   |..|..|.....:|  ||:..
Human  2461 MGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVG--SQWAS 2523

  Fly  1062 PSSTLFSDITKISNTDKDHPTLDEEENISKSPLHLSTTSSSLPKIQITGVSHLPFLSTISNIKFE 1126
            |                ::|.|..|....|..:.:...:.|.|::::      |...:...:..:
Human  2524 P----------------ENPCLINECVRVKEEVFIQQRNVSCPQLEV------PVCPSGFQLSCK 2566

  Fly  1127 QSS-FHGCDC----TCQLE---IGK------DSC-ICECNLKESTSEGLKSVTASSLYIYLPQSS 1176
            .|: ...|.|    .|.|.   ||.      |.| .|.|.::.....|.|          |....
Human  2567 TSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFK----------LECRK 2621

  Fly  1177 TTAHSLLTDLSAENQTNQ 1194
            ||.:........||.|.:
Human  2622 TTCNPCPLGYKEENNTGE 2639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
VWF	NP_000543.3	VWD	35..179	CDD:395046
		C8	222..291	CDD:214843
		TIL	295..348	CDD:410995
		VWC	350..>394	CDD:327433
		VWD	377..540	CDD:214566
		C8	584..648	CDD:400886
		TIL	652..707	CDD:410995
		Amino-terminal	764..787
		E1	788..833
		TIL	<788..827	CDD:410995
		CX	826..853
		VWD	856..1011	CDD:214566
		C8	1053..1127	CDD:214843
		TIL	1146..1196	CDD:410995
		VWA_N2	1198..1276	CDD:406551
		VWA	1277..1449	CDD:214621	19/94 (20%)
		VWA	1498..1658	CDD:395045	31/176 (18%)
		VWA	1691..1862	CDD:395045	36/196 (18%)
		VWD	1950..2102	CDD:395046	20/153 (13%)
		C8	2138..2199	CDD:400886	3/60 (5%)
		TIL	2203..2254	CDD:410995	7/50 (14%)
		E2	2216..2261		6/44 (14%)
		VWC	2261..2321	CDD:214564	12/64 (19%)
		VWC	2431..2494	CDD:214564	14/74 (19%)
		Cell attachment site	2507..2509		0/1 (0%)
		VWC	2582..2644	CDD:278520	16/68 (24%)
		CT	2727..2808	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900