DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and Vit

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_083089.1	Gene:	Vit / 74199	MGIID:	1921449	Length:	650	Species:	Mus musculus

Alignment Length:	661	Identity:	122/661 - (18%)
Similarity:	206/661 - (31%)	Gaps:	198/661 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly 15368 TQIITEKSTTNNLSVHSNI-DKS--TISTQPYFDTDTTKYSTSVGVLSEESSKLTKQNITEEITT 15429
            |.:....|:....::||.: |.|  .|..:........|.|.|.||.|....:..:..|..|
Mouse    76 TGVYASYSSVCGAAIHSGVLDNSGGKILVRKVAGQSGYKGSYSNGVQSLSLPRWRESFIVAE--- 137

  Fly 15430 NILSLP-SNIATSTTLTQPHSDT------DKTEAIQNQTTAGHTTQDSSVIGLLSKEPTQTLTFS 15487
               |.| ..:|..:|||...|.|      :.|:|.:..:..|.|.|           |. |||.:
Mouse   138 ---SKPQKGVAYPSTLTYSSSKTAAAKAGETTKAYEKPSIPGTTIQ-----------PV-TLTQA 187

  Fly 15488 KLSPTQIITEKSTSNNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGVLSEE-------------- 15538
            :.:|...:|.:|||...:  :::.||. ..||            ||..|:|
Mouse   188 QATPVAEVTHRSTSKPFA--ASVTNSP-RPQP------------VGHRSQEMEEVDGWKPGPVLL 237

  Fly 15539 -SSKLTKQNITEEITTNILSLPSNIATSTTLTQ--PHSDTDKTEAIQNQTTAGHTTQD------S 15594
             |..:.|    ||::|.         :|..:.|  |:...|.:..|...|:.|.....      :
Mouse   238 DSGFVPK----EELSTQ---------SSEPVPQGDPNCKIDLSFLIDGSTSIGKRRFRIQKQFLA 289

  Fly 15595 SVIGLLSKEPTQTLTFSKLSPTQIITEKSTTNNLSVHSNIDNSTISTQPYFDTDTTKYSTSVGVL 15659
            .|:..|...|...|    :...|.....:|..||..|.|
Mouse   290 DVVQALDIGPAGPL----VGVVQYGDNPATQFNLKTHMN-------------------------- 324

  Fly 15660 SEESSKLTKQNITEEITTNILSLPSNIATSTTLTQPHSD----------------TDKTETIQNQ 15708
             .:..|...:.||:....:.:....:..|.|..::.:.:                |||.|.:...
Mouse   325 -SQDLKTAIEKITQRGGLSNVGRAISFVTKTFFSKANGNRGGAPNVAVVMVDGWPTDKVEEVSRV 388

  Fly 15709 -----------TTAGHTTQDSSVI---GLLSKEPTQTLTFSKLSPTQIITEKSTSNNLSVHSNID 15759
                       |..|...:|...:   |..||...:|..|...         :..:.||:|..:
Mouse   389 ARESGINVFFITVEGAAERDIQHVVEPGFASKAVCRTNGFYSF---------NVQSWLSLHKTV- 443

  Fly 15760 NSTISTQPYF----DTD------TTKYSTSVGVLSEASSKLTKQNITEKSTTNILSLPSNIATST 15814
                  ||..    |||      |...|..:|.:.:.||.:...|.     ..:|...:|::...
Mouse   444 ------QPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSMGTSNF-----RTVLQFVANLSKEF 497

  Fly 15815 TLTQPHFYTDKTETTGNQTSTEHTSKYSTTVEFLS----------------KEQTSIIPTFSKLE 15863
            .::.........:.|..|.......||::..:.||                ..|.::...|.|.:
Mouse   498 EISDTDTRVGAVQYTYEQRLEFGFDKYNSKADILSAIRRVGYWSGGTSTGAAIQYALEQLFKKSK 562

  Fly 15864 PTEH-----ISNNKKFTSNGTTEYVISQSNNKTYSDSQLISTTENLILTASSQPTDVNVWKEIDK 15923
            |.:.     |::.:.:...........|....||:.....:..:.|.:.|:....|.:.:
Mouse   563 PNKRKVMIIITDGRSYDDVRIPAMAAYQKGVITYAIGIAWAAQDELEVMATHPAKDHSFF----- 622

  Fly 15924 RLDDLQNKYTI 15934
             :||..|.|.|
Mouse   623 -VDDFDNLYKI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
Vit	NP_083089.1	LCCL	44..133	CDD:281766	13/56 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..226		11/42 (26%)
		vWFA	265..428	CDD:294047	30/193 (16%)
		vWA_collagen	466..626	CDD:238749	24/170 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900