DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and Vwce

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_082189.1	Gene:	Vwce / 71768	MGIID:	1919018	Length:	929	Species:	Mus musculus

Alignment Length:	867	Identity:	168/867 - (19%)
Similarity:	255/867 - (29%)	Gaps:	319/867 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 MCDCTCKLEIAKDSCICECNLKKSTSDIS-----KGVTA-SASNQSLPTETNRKLHSMKDYAPNG 704
            :|..||...:....|.|....:..:..:|     |.|.| ||..|  |.:...|:..:...| ..
Mouse   232 VCHHTCHNTVGSFLCTCRPGFRLRSDRVSCEAFPKAVLAPSAILQ--PRQHPAKMSLLLPEA-GR 293

  Fly   705 TSLLTNASPEPFTIDDVTYKGNLAGKKT-TMPSELSSLKKIEPVKTHDVCECTCLLEQGNDSCTC 768
            .:|....||.|..      .|...|.:| :.||....|....|
Mouse   294 PALSPGHSPPPGA------PGYPTGVRTISQPSTTQVLPTFFP---------------------- 330

  Fly   769 NCMTDFISTSIQISS----TGPDQISQNKMGNQSQ----SVPLLNTEFSDLMKISTTYKMHQTQN 825
               |..|||.:..||    .||..:.|..:|..|.    ..|.|....|....:..||:
Mouse   331 ---TQLISTPVPSSSPLGTLGPPSLLQGAVGTPSSPRGPESPKLGAGSSSCWHLGATYE------ 386

  Fly   826 DIEKLSKSPPVLSTTSSGLPKWPTTRTLEKKKQQSKSLPSLSTISNFHFEKSNFHGC-DCTCQ-- 887
                            || .:|                              |..|| .|.||
Mouse   387 ----------------SG-SRW------------------------------NQPGCSQCLCQDG 404

  Fly   888 -LELGRDSCICECNFKESTSDVSTSRSNQPLPTK-----------LHSVKDNAPHSLTNANPESL 940
             :..|...|...|              :.|:|.:           .||....|...:.:. ||..
Mouse   405 EVTCGGVRCDATC--------------SHPVPPRDGGCCPSCTGCFHSGAIRAEGDVFSP-PEEN 454

  Fly   941 TSKDLTTKGNGVTDNKITTLS--------KLSSDNVCECTC----------------LLEQGNDS 981
            .:..:...||      ::.:|        |.|..:.| |||                :...|.|.
Mouse   455 CTVCVCLAGN------VSCISPECPPGPCKASPQSDC-CTCVPGRCYFHGRWYTDGAVFSGGGDD 512

  Fly   982 CTCNCMTDTNSIDESILTASQIVSSEDLQYSSNPPSYKST-QENTNTKG----KNKNLSTLLQIS 1041
            || .|:.....::.|.....::....: ::...|.....| :|.|.|.|    .|.....:.||.
Mouse   513 CT-TCVCQNGEVECSFTPCPELECPRE-EWLLGPGQCCFTCREPTPTTGCSLDDNGVEFPIGQIW 575

  Fly  1042 STG-PYQ--IYQSEIGNQS------------------QYVPPSSTLFSDITKISNTDKDHPT-LD 1084
            |.| |.:  :.|:: |:.|                  |..|..|...:...:|...::..|: ||
Mouse   576 SPGDPCELCVCQAD-GSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLD 639

  Fly  1085 EEENISKSPLHLSTTSSSLPKIQITGVSHLPFLSTISNIKFEQSSFHGCDCTCQLEIGKDSCIC- 1148
                                          |.||.|..:.....|...|..||......|...|
Mouse   640 ------------------------------PCLSCICLLGSVACSPVDCPITCTYPFHPDGECCP 674

  Fly  1149 ---ECNLKESTSEGLKSVTASSLYIYLPQSSTTAHSLLTDLSAENQTNQEETSELSESLP--QLT 1208
               :||.     ||.| |....::....:..|.....|.::|.             |::|  .:.
Mouse   675 VCHDCNF-----EGRK-VVNGQVFTLDDEPCTRCICQLGEVSC-------------ETVPCRPIC 720

  Fly  1209 TEESSSFQESSAEENQM-----------------TEVPWTLTTSLS-QSSSKTKNIFSSLS---- 1251
            |:.|........||.|.                 ||||...::... .|:|.|:.:...|.
Mouse   721 TDPSCPDSVFPLEEKQQPSPHGELAKAARNARGDTEVPVNCSSCPGPPSASPTRPMVHLLQRLLR 785

  Fly  1252 VNEDNISQEDTRTLSISVPQSIATANSLL----------TGSSAEEHTAQEETSELSKSLP---- 1302
            .|..||     ::.|.|.|.:..:::.||          ..|...|.:|....|....:||
Mouse   786 TNLSNI-----QSASPSPPIAQTSSSPLLEPEGISLGKPRASQPPEPSAGSPVSPRLSTLPPAIP 845

  Fly  1303 -----QLTTEESSS-------FQ-------ESSAEENQMT--EVPWTLTTSLSQSSSKTKNIFSS 1346
                 .:|.|.|||       ||       .:.||...||  ::..||||     ||.::.:.::
Mouse   846 GTPLSPVTPESSSSTFGTQTAFQWLLSATPLTEAETPSMTNADLSETLTT-----SSSSQRLSAA 905

  Fly  1347 LSVNEDNISQEDTRTPSISVPQ 1368
            |....:.:.|:.|    |..|:
Mouse   906 LPDTPNPVPQQST----IDTPK 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
Vwce	NP_082189.1	EGF_CA	142..180	CDD:214542
		cEGF	200..223	CDD:289433
		EGF_CA	220..262	CDD:214542	6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..317		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..374		9/34 (26%)
		VWC	378..432	CDD:302663	16/120 (13%)
		VWC	493..551	CDD:302663	7/59 (12%)
		VWC	564..617	CDD:214564	11/53 (21%)
		VWC	621..676	CDD:302663	14/84 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..774		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..861		17/74 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..929		15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900