DRSC/TRiP Functional Genomics Resources

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Protein Alignment Muc14A and vwf

DIOPT Version :9

Sequence 1:NP_727928.3 Gene:Muc14A / 318097 FlyBaseID:FBgn0052580 Length:16223 Species:Drosophila melanogaster
Sequence 2:NP_001268918.1 Gene:vwf / 570643 ZFINID:ZDB-GENE-070103-1 Length:2812 Species:Danio rerio


Alignment Length:2481 Identity:422/2481 - (17%)
Similarity:768/2481 - (30%) Gaps:849/2481 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly 10200 QLTTEESSSFQ--------------ESSAEKNQMTEVPWTLSTSL---------------SQSSS 10235
            |||.|:..|.|              |.||::..:|:.|:..:.|.               |||.:
Zfish   141 QLTLEKRHSNQTCGLCGNYNYLAEDEYSAQEGFLTDDPYDFANSWAMKGADEPCKRVLPPSQSCN 205

  Fly 10236 KTMNIFSSQNVKEDKTFQEDTRTQSISFPQSSTKANSLLSVSRAEEQSSQFSSLDMIEPITSSKL 10300
            .|     .::.|:..:..|..|: |:.|...:                      .:::|.....:
Zfish   206 ST-----GESTKDQMSACESMRS-SVLFMHCA----------------------HLVDPAAFVSV 242

  Fly 10301 STHNDCECTCLLEQGKDSCTCNCMTDTNSIDKSILTASQIVSSEDLQYSSNPLSYKSTQENTNTK 10365
            ...:.|.|:.    ||: |.|..|                     |:||....|...|..|.:| 
Zfish   243 CESDVCHCSA----GKE-CVCQAM---------------------LEYSRACASRGITLSNWHT- 280

  Fly 10366 GKNKNLSTLLQISSTGPYQISQSEIGNQSQYVP--PSSTLFSDITKISNTDKDHPTLDE---EEN 10425
                                       |||..|  |....:||.|...:|...:..:.|   ||.
Zfish   281 ---------------------------QSQCSPKCPVGMEYSDCTPTCSTSCQNVNIQEVCKEEC 318

  Fly 10426 ISKSPLHLSRTSSSLPKIQITGVSHLPFLSTISNIKFEQSSFHGCDCTCQLEIGKDSCICECNLK 10490
            :........:.......:.::..|     .|.:..::..:|:...||        ::|:|.....
Zfish   319 VDGCICPAGKVLDGDRCVDVSQCS-----CTHAGRRYPPASYISQDC--------NTCVCRHGSW 370

  Fly 10491 ESTSERLKS---VTASSLYIYLPQS----STTAHSLLT-DLSAENQTNQEETSELSKSLPQLTTE 10547
            |.|:|....   ||..|.|......    |...|.||. |..:.:.:...||::.:.....:.|.
Zfish   371 ECTNEGCPGECLVTGQSHYKTFDNKFFTFSGICHYLLAKDCQSNSFSAVIETAQCADDQDAICTR 435

  Fly 10548 EIS-SFQESSAKENHM------------TEEPW---------TLSTSPR---------------Q 10575
            .|: .|::.:.:..|:            .:.|.         |:.:|.|               :
Zfish   436 SITLRFKDLANQTVHLKHGGVVSVDGMDVQTPLINGPLRIQNTVLSSVRLRYGHDLHLDWDGRGR 500

  Fly 10576 SSSKTKNIFSSQ----------SVNEDKVS---LENTRTLSTSQSITITNSLLTDLSAEDQTNQE 10627
            ...:.|..::.|          :..:|.::   |..||..:      ..||...:...:|     
Zfish   501 VLLRLKPAYAGQMCGLCGNYNGNQGDDFLTVGGLVETRVEA------FGNSWKMNADCDD----- 554

  Fly 10628 ETSELSNSVPQLTTEESISF-QESSAKQNQITEEPWTLSTSP-PQSSSKTKNIFSSQSVNE---D 10687
              .::.||.|.....:.:.| :|:.|....:..||.....:| |...:...::.:.....|   |
Zfish   555 --VQMQNSDPCSLNPKRVRFAEEACAVLLSMKFEPCHYMVNPEPYVKNCRYDVCACADGQECLCD 617

  Fly 10688 KVSLEDTRTLSTSQSITITNSLLTDLSAEDQTNQEETSELSNSVPQLTTEESISFQESSAEQNQM 10752
            .||.......:....:...:....:|:..|....|....:.|.     |..|:|..::..:  .:
Zfish   618 AVSSYAVACAARGVLVNWRSHGYCELTCPDAQVYEMCGSVCNQ-----TCRSLSLPDTGCD--GV 675

  Fly 10753 TEE----PWTLSTS------PPQSSSKTKN--IFSSQSVNEDKVSLEDTRTLSISQSITM----- 10800
            .||    |..|..|      |||..|...|  ||      |....:.|..::.:.:|.:|     
Zfish   676 CEEGCFCPRGLFLSDAGECVPPQHCSCHHNGEIF------EPNDMIGDHHSICVCESGSMHCTSN 734

  Fly 10801 --TNSPLTDLSAEDQTNQEETSELSNSVPQLTTEESSSFQESSGEENHITEVPWTLSTSLSQSSS 10863
              |.|.|:||..::|:.......|| ..|.|...|..|.:::..|                  .:
Zfish   735 EATGSTLSDLFFDEQSPSRGRRSLS-CPPPLQRFECESARDAGIE------------------CA 780

  Fly 10864 KTKNIFSSQNVKED----------------KTFQEDTSISFPQSSTKA--NSFLTVSRVDEISSQ 10910
            ||     .||::.|                ..:::|   ..||.....  ||             
Zfish   781 KT-----CQNLELDCVSLGCVSGCMCPPGTVRYRKD---CIPQEQCPCYHNS------------- 824

  Fly 10911 FSSLDMIEPITSSKLSTHNDCECTCLLEQGKDSCT-------CNCMTDTNSIDESILTASQIVSS 10968
                   .|..|.: |...||. ||:.||.:..|:       |..:.||:           .:|.
Zfish   825 -------RPYESGQ-SITVDCN-TCVCEQRQWKCSERVCDGVCRAIGDTH-----------YISF 869

  Fly 10969 EDLQYS-SNPPSYKSTQENTNTKGKNKNLSTLLQISSTG--PYQISKRIPSSSTLFSD---IIKI 11027
            :.|::| ..|..|...|:..|  |.:.....|::.|:.|  .|:.||.|   :.|:..   :::.
Zfish   870 DGLKFSFPGPCQYVLAQDYCN--GLDGTFRVLVENSACGIAGYRCSKSI---TVLYMGGLIVMEH 929

  Fly 11028 SSTDKDHPTLDEEENISKSPLQLSTTSSSLPKIQITGISHLPFLSTISNIKFEQSSFHGCDCTCQ 11092
            .......|.|.|.|                .:|..:|:.::..|....:|.::.    |...:.|
Zfish   930 GEVRMKRPVLKETE----------------VEIVRSGLYYIVLLGKHISITWDT----GTRISLQ 974

  Fly 11093 LEIRKDSCICE-C-NLKESTSERLKSVTASSLYIYLPQSSTTAHSLLTDLSAENQTNQEETSELS 11155
            :..:....:|. | |...|.:..|                         ||:.||. :.:.::..
Zfish   975 ISGQYRGKVCGLCGNFDGSQNNDL-------------------------LSSSNQM-EVDAADFG 1013

  Fly 11156 NSVPQLTTEESISFQESSAEQNQMTEEPWTLSTSPPQSSSKTKNIFSSQSVNEDKVSLEDTRTLS 11220
            ||                          |.:..                               |
Zfish  1014 NS--------------------------WKVRP-------------------------------S 1021

  Fly 11221 TSQSITITNSLLTDLSAEDQTNQEETSELSKSLPQLTTEESISFQESS--AEQNQMTE-EP-WTL 11281
            .:.::::.:...|||                 :..:|.|:|.....|:  .:.|.:.: || |.:
Zfish  1022 CADAVSVVSQCSTDL-----------------VKLVTVEQSCRVLTSAIFRDCNSVVDPEPYWDI 1069

  Fly 11282 STSPPQSSSKTNIIFSSQSVNEDKTSLEDTRTL-STSQSITITNSL------------------- 11326
            .|                         :||.:. |........|::                   
Zfish  1070 CT-------------------------QDTCSCPSVGDCACFCNTIAAYAHECAQKGLPVNWRSN 1109

  Fly 11327 -LTDLSAEDQTNQE-------ETSELSNSVPQLTTE-ESISFQESSAE-------QNQMTEEPWT 11375
             |..||.|| .|:|       ..:..:::.|..... |.:|...|..|       ...:.:|...
Zfish  1110 DLCPLSCED-LNKESGVQCEWRYNTCASACPSTCQHPEPLSCPISCVEGCHAVCPPGHLLDEVLR 1173

  Fly 11376 LSTSPPQSSSKTKNIFSSQSVNEDKVSLEDTRTLSTSQSITITNSLLTDLSAEDQTNQEETSELS 11440
            ....|.|.                :|.:.|.:.:|..:...:              |.|:     
Zfish  1174 KCVEPSQC----------------QVCVHDGQRVSHGKQFIL--------------NHED----- 1203

  Fly 11441 NSVPQLTTEESISFQESSAEQNQMTEEPWTPSTSLPQTSSKTNIT-----FS------------- 11487
               |:|.       |....|.|.:|..| .|.|.|..|.:.|.:|     ||             
Zfish  1204 ---PRLC-------QICHCESNTLTCGP-CPVTGLTSTLAPTTVTPTPLPFSTPVPADACDRAMD 1257

  Fly 11488 -------SQSVNKDKTSLEDTRTLSISQSITMTNSP------LTDLSAEDQTNQEETSELSKSLP 11539
                   |.::::|..|:.....|.:.:...|.::.      |.....:....|.:.....|.:.
Zfish  1258 LAFLVDGSSALSEDDFSMIKLFILRVVERFRMGSAHTRATVLLFHSGVKSYDMQVQKWIFKKMVR 1322

  Fly 11540 QLT-TEESISFQESSAEQNQMTEEPWTLSTSPPQSSSKTNIIFSSQSVNEDKTSLEDTRTLSTSQ 11603
            ::. |...::|.:.:.:...:    :....:..:.:.:..|:.::.:   :...:..|:.|...:
Zfish  1323 EMRYTGGDVAFMDEAIKYLAV----YIYDKNKREHAGRVAILLTASA---NPRPMRSTQRLLRKK 1380

  Fly 11604 SITITNSLLTDLSAEDQTNQEETSELSNSVPQLTTEESISFQESSAEQNQMTEEPWTLSTSP-PQ 11667
            .|||    ||.....| .|..:.:|::.:.|........|..|...|...:|:...||...| ||
Zfish  1381 DITI----LTVALGPD-VNMAQVNEITKATPSSRAYVVSSVTELDDEALSITDYLCTLGLDPEPQ 1440

  Fly 11668 SSSKTKNIFSSQSVNEDKVSLEDTRTLSTSQSITITNSLLTDLSAEDQTNQEETSELSNSVPQLT 11732
            ....|..                    .::.|:|.|.:.:|.|:.      ..|:.:..:.|.:.
Zfish  1441 KKPPTAK--------------------PSTTSVTPTTNAITKLTI------PPTAAIVTAFPSIP 1479

  Fly 11733 TEESISFQESSAEQNQMTEEPWTPSTSL-PQTSSKTNIIFSSQSVN---EDKTSLEDTRTLSTSQ 11793
                                  ||.|:| |.|.:..:::|..::.|   ||  ....||      
Zfish  1480 ----------------------TPGTTLVPTTVTTYDLVFLLENANATGED--GFNKTR------ 1514

  Fly 11794 SITITNSLLTDLSSEDQTNQEETSELSKSLPQLTTEESISFQE-SSAEQI--QMTEEPWTLSTSP 11855
                 :||:..::|.|| .:.|...::..:..:|....||..| ...||:  :|.:..||     
Zfish  1515 -----DSLINIITSLDQ-KEAENLRITVMMYSVTVTVEISRMELHHREQVVQRMRQLRWT----- 1568

  Fly 11856 PQSSSKTNIIFSSQSVNEDKTSLEDTRTLSTSQSI-TITNSLLTDLSSEDQTNQEETSELSKSLP 11919
              ..::.|...:.|||.|..|:  ||.:.:..|.: .||.|..||:.      |...|...|.:.
Zfish  1569 --EGAEVNTGHAVQSVYETITT--DTHSDTPDQLVFLITQSPPTDVI------QRPPSSTHKKIY 1623

  Fly 11920 QLTTEESISFQE----SSAEENQMTEEPWTLST--------------------------SPAQSS 11954
            .:.....|.:::    |..::..|.::|..|.|                          .|:...
Zfish  1624 PIGIGRKIRYEDLALLSFPDKPIMLDDPSDLRTLQPMLINISRTVRRPLLPTLPPRATLPPSVPC 1688

  Fly 11955 SKTKNIF-----SSQSVNED-----KTSLEDTRTLLTSQSITI----TNSLLTELSAEDQTNQEE 12005
            ||..::.     ||.|..||     ||.::.|........:.:    ..|.:.....::|| |:.
Zfish  1689 SKPMDVLFLLRASSGSQFEDLKTFVKTFIKSTNIGRNDTQVAVMVYGAKSAVAVTWRDEQT-QDN 1752

  Fly 12006 TSELSNSL-------PQLTTEESISFQESSAEQNQMTEEPWTLSTSPPQSSSKTNIIF--SSQSV 12061
            ..:|..||       |:|.....::.|.:.:            |||..:......::.  :.:|:
Zfish  1753 LLKLLESLHGKTDNQPRLGAALRLAVQTAVS------------STSGARMGIPKAVVMVVTDRSI 1805

  Fly 12062 NENKTSLEDTRTLSTSQSITITNSLLTDLSAEDQTNQEETSELSNSVPQL--------TTEESIS 12118
            :..:.:..:..|...|         :..:....|.:|.|.:.|:.  ||.        :||..:|
Zfish  1806 DSVQEAANEALTAGVS---------VFPIGLGKQYDQIEVNTLAG--PQAQENVILLGSTEYLLS 1859

  Fly 12119 ---FQESIAEQNQMTEEPWTLSTSPPQSSSKTNIIFSSQSVNENKTSLEDTRTLSTSQSITITNS 12180
               |.:|..::        .....||.       :......||.|..  :|..|:......:.|.
Zfish  1860 MAAFDQSFPDK--------LCRAGPPG-------VCVDDEGNERKPG--ETWMLADGCHSVLCNP 1907

  Fly 12181 LLTDLSAEDQTNQEKTSE--LSNSVPQL-------------------TTEESISFQESSAEQNQM 12224
            ..|......:.|.||...  ..|::|.|                   :|...:||..::.:....
Zfish  1908 SGTITMQSHRINCEKMEPPVCKNNLPALRYNHHCGCTWTCPCSCMGSSTSHVVSFSGAALKVKSA 1972

  Fly 12225 TE--------EPWTLSTSLPQTSSKTNITFSSQSVNEDKTS--LEDTRTLSISQSITMTNSPLTD 12279
            ..        ....|.|:..| ||...|...|..:.|..||  |:|...:::...:|        
Zfish  1973 CSYLLLRSGGAELVLHTTACQ-SSPNQICMKSLELREGGTSVVLQDDMKVTVGGVLT-------- 2028

  Fly 12280 LSAEDQTNQEETSELSKSLPQLTTEE---SISFQESSAE---QNQMTEEPWTPSTSLPQSSSKTN 12338
             :...:|.:...:::...|.||.:|:   :::|...|.|   ...:..:|.|.......|..::.
Zfish  2029 -AVPFRTERVTVTQIGSILHQLRSEQHGFTLTFTPHSNEFMLNMDIAMKPNTTGLCGSCSDDQSG 2092

  Fly 12339 NIFSSQSVNED 12349
            .:.|..||..|
Zfish  2093 LLLSDGSVTTD 2103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc14ANP_727928.3 PRK14949 <11377..11776 CDD:237863 68/432 (16%)
PRK08581 11922..>12215 CDD:236304 61/377 (16%)
PRK14949 <13679..14114 CDD:237863
PRK14949 <14663..15055 CDD:237863
vwfNP_001268918.1 VWD 29..167 CDD:278521 6/25 (24%)
C8 <227..284 CDD:214843 18/132 (14%)
TIL 288..341 CDD:280072 8/52 (15%)
VWC 343..>387 CDD:302663 11/51 (22%)
VWD 381..534 CDD:278521 22/152 (14%)
C8 573..641 CDD:285899 10/67 (15%)
TIL 645..700 CDD:280072 14/61 (23%)
TIL 760..818 CDD:280072 13/83 (16%)
VWD 847..1003 CDD:214566 37/216 (17%)
C8 1043..1112 CDD:285899 12/93 (13%)
TIL 1131..1181 CDD:280072 7/49 (14%)
VWA_N2 1183..>1222 CDD:292782 12/68 (18%)
VWA 1257..1421 CDD:278519 24/175 (14%)
vWFA_subfamily_ECM 1493..1628 CDD:238727 38/163 (23%)
VWA 1693..1848 CDD:278519 30/178 (17%)
VWD 1939..2091 CDD:214566 27/161 (17%)
C8 2131..2194 CDD:285899
CT 2731..2808 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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