DRSC/TRiP Functional Genomics Resources

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Protein Alignment Muc14A and NEFM

DIOPT Version :9

Sequence 1:NP_727928.3 Gene:Muc14A / 318097 FlyBaseID:FBgn0052580 Length:16223 Species:Drosophila melanogaster
Sequence 2:NP_005373.2 Gene:NEFM / 4741 HGNCID:7734 Length:916 Species:Homo sapiens


Alignment Length:1059 Identity:202/1059 - (19%)
Similarity:376/1059 - (35%) Gaps:226/1059 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  6064 TGSSAEEQTAQEETSELSNSLPQLTTEESSSFQKSSAEENQMTEVPWTLSTSLSQSSSQAKNIFS 6128
            |..|....:|....:|..:|..:::...||.|:..|.....    |.|:|:|..:|....:..:|
Human     4 TLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGS----PSTVSSSYKRSMLAPRLAYS 64

  Fly  6129 SQSLNEDNISQEDTRTPSISVPQSIATANSLLTGSSAEEQT----------------AQEETSEH 6177
            |..|:....|.:.:::.|:....|....:..|:.|:.:||.                .:::..|.
Human    65 SAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEI 129

  Fly  6178 SKSLPQLTTEESSSFQKSSAEENQMTEVPWTL-------------STSLSQSSSQAKNIFSSQSL 6229
            ...:..|..:::|..|...|.:.::.|:..||             |..|.:...:.|..|..::.
Human   130 EAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR 194

  Fly  6230 NEDNISQEDTRTPSISVPQSIATANSLLTGSSAEEQTAQEET----SEHSKSLAQLTTEESSSFQ 6290
            ..|     ||.....::.:.|..|:.:......:.|:.|:|.    |.|.:.:|.|..:..:|..
Human   195 LRD-----DTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHI 254

  Fly  6291 ESSAEENQTTEVPWTLSTSPSQSSSKTKNIFSSQSVNEDK-----------TSQEDTRTLPISVP 6344
            ....::...|::...|....||..|     .|.|::::.:           .:.|..:....|..
Human   255 TVERKDYLKTDISTALKEIRSQLES-----HSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAK 314

  Fly  6345 QSIATTNSLLTGSSAEEQTAQ--EETSEHSKS-LPQLTTEESSSFQESSAE-ENQMTEVPWTLST 6405
            :.||.....|...|.|.::.:  :|:.|...| :.:....:.||:|::..: ||::....|.::.
Human   315 EEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMAR 379

  Fly  6406 SLS--QSSLQAK-----NIFSSPNLNEDNISQEDTR--------TLPISVPQSIATANSLLTEPK 6455
            .|.  |..|..|     .|.:...|.|.    |:||        |.|:...:...|.:|.:.:||
Human   380 HLREYQDLLNVKMALDIEIAAYRKLLEG----EETRFSTFAGSITGPLYTHRPPITISSKIQKPK 440

  Fly  6456 NIFSSQSLNEDNISQEDTRTPSISVSQSSTTANRLLTGSIAEEQTAQEETSEHSKSLPQLTTEES 6520
                             ...|.:.|...       ....|.||...::|.||..::|..:|.|.:
Human   441 -----------------VEAPKLKVQHK-------FVEEIIEETKVEDEKSEMEEALTAITEELA 481

  Fly  6521 SSFQESSAEENQTTEVPWTLSTSPSQSSSKTKNIFSSPSLNEDNISQEDTRTLPISVPQSIATAN 6585
            .|.:|...|..:..|                    ..|...|:.::.:.:   |:.     |||.
Human   482 VSMKEEKKEAAEEKE--------------------EEPEAEEEEVAAKKS---PVK-----ATAP 518

  Fly  6586 SLL-TGSSAEEQTAQEETSEHSKSLPQLTTEESSSFQESSAEENQMTEVPWTLSTSLSQSSSEPK 6649
            .:. .....||:..|||..|..:.......||..|.:|.|:|:.:..:.............:|.|
Human   519 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583

  Fly  6650 NIFSSQSLNEDNISQEDTRTLPISVPQSIATANSLLTGSSAEEQTAQEETSEHSKS-LPQLTTEE 6713
                    .|..:.::.         :.:||...|:.       .|:.|..|.:|| :|:...||
Human   584 --------EEKKVEEKS---------EEVATKEELVA-------DAKVEKPEKAKSPVPKSPVEE 624

  Fly  6714 --SSSFQESSAEENQTTEVPWTLSTSPSQSSSKTKNIFSSPSLNEDNISQEDTRTLPISVPQSIA 6776
              .|...:|..||...:.||    .||.:...|:. :..||        .|:....|:|......
Human   625 KGKSPVPKSPVEEKGKSPVP----KSPVEEKGKSP-VPKSP--------VEEKGKSPVSKSPVEE 676

  Fly  6777 TANSLLTGSSAEEQTAQ------EETSERSKSLPQLTTEESSSFQESSAE---ENQTTNQSVNED 6832
            .|.|.:..|..||..::      |:..|..|.:.:...||....:|...:   |.:.....|.|:
Human   677 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 741

  Fly  6833 KTSQEDTRTLSISVPQSIATTNSLLTGSSAEEQTAQEETSEDSKSLPQLTTEESSSFQESSAEEN 6897
            ..::..|.|.|:.|                   ..::||.|:.|.|.|...:|.:..:..|.||.
Human   742 AVAEVVTITKSVKV-------------------HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEG 787

  Fly  6898 QTTEVPWTPSTSPSQSSSKTKNIFSSQSVNEDKTSQEDTRTLSISVPQSIATTNSLLTGSSAEEQ 6962
                     |...::.|.|.....:.:...:::..||.....|....:....||. |..|.|:|:
Human   788 ---------SDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG-LDLSPADEK 842

  Fly  6963 TAQEETSEH---SKSLPQLTTEESSSFQESSAEENQMTEVPWTLSTSLSQSSSKTKNIFSSQSVN 7024
            ...:::.|.   :|::.::|:|......:..           |.|.:::|...:.:..|..:.|:
Human   843 KGGDKSEEKVVVTKTVEKITSEGGDGATKYI-----------TKSVTVTQKVEEHEETFEEKLVS 896

  Fly  7025 EDKTSQEDTRTLSISVPQS 7043
            ..|..:..:..:...|.||
Human   897 TKKVEKVTSHAIVKEVTQS 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc14ANP_727928.3 PRK14949 <11377..11776 CDD:237863
PRK08581 11922..>12215 CDD:236304
PRK14949 <13679..14114 CDD:237863
PRK14949 <14663..15055 CDD:237863
NEFMNP_005373.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 12/50 (24%)
Head 2..104 22/103 (21%)
Filament_head 10..78 CDD:282575 16/71 (23%)
Filament 100..411 CDD:278467 58/324 (18%)
Coil 1A 105..136 1/30 (3%)
Linker 1 137..149 2/11 (18%)
Coil 1B 150..248 19/102 (19%)
Linker 12 249..265 1/15 (7%)
Coil 2A 266..287 6/25 (24%)
Linker 2 288..291 0/2 (0%)
Coil 2B 292..412 25/123 (20%)
Tail 413..916 120/632 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..851 89/459 (19%)
6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK] 614..691 24/89 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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