DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and 9530053A07Rik

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_001158127.1	Gene:	9530053A07Rik / 319482	MGIID:	2442118	Length:	2581	Species:	Mus musculus

Alignment Length:	847	Identity:	161/847 - (19%)
Similarity:	252/847 - (29%)	Gaps:	277/847 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 TPKKSTNRFASVLQLNAVTDSSIKVLNTKTDQFD------TEEETSLSEFLPEWPTVLGSSLQFS 561
            |.|..:|.|.||..|..         |...|..|      ..|.....:|..:|  ::.|.|...
Mouse   572 TAKVPSNYFNSVCGLCG---------NFNGDPRDDLGKQIRAEAIDPRDFGKKW--LVSSHLGCR 625

  Fly   562 TIETQ--PSTNNGQLTH-TEKTTLSKSIN-HIKH-HKINLGQNA--EAASHFNIQPGALHTISTT 619
            |.|..  |..|.|.::: |:...:..:|: |.|| .::....:|  |.|......||....:..|
Mouse   626 TDEQHLCPDFNKGLVSNITQNCRIFTNISGHFKHCWRVPAYNSAYIECAYDCCRMPGQTKPLCDT 690

  Fly   620 GGYHPTVKKK--------QSETL-PLLSTKSISLNMCDCTCKLEIAK------------DSCICE 663
            ...:..:.:.        ::||| |:.........:|...|.|....            :||:|:
Mouse   691 LATYTAICQSSGVIVYPWRTETLCPMTCPPHSHYELCQRGCPLTCGDQPVPGGCGSDCYESCVCD 755

  Fly   664 ---------CNLKKSTSDISKGVTASASNQSLP-TETNRKLHSMK-------------------- 698
                     |....|...:.:|:..:..::..| .|.|...|..|
Mouse   756 EGYVLSGEACVPLASCGCVYQGIYHAPGDEFYPGPECNSLCHCDKGGLVSCQPSHCSPHEVCKVL 820

  Fly   699 ------------------------------DYAPNGTSLL-----TNASPEPFTI-DDVTYKGNL 727
                                          |:......:|     |....:|||| .:...:||
Mouse   821 DGILRCVGEGSATCQVSGASHYTTFDGRHFDFMGTCVHVLAQTCWTRPGLKPFTILQENAVQGN- 884

  Fly   728 AGKKTTMPSELSSLKKIEPVKTHDVCECTCLLEQGNDSCTCN-------CMTDFISTSIQISSTG 785
                    .::|..|||    |.:|...|..|||.......|       .:.|  ...:|....|
Mouse   885 --------KQVSVTKKI----TIEVANYTLQLEQNQWKVKVNGVDMKLPVLLD--EDRVQAFRHG 935

  Fly   786 PDQISQNKMGNQSQSVPLL---NTEFSDLMKISTTYKMH----------QTQNDIEKLSKSPPVL 837
            .|.:.:.|.|       ||   :.::|..:|:...|..|          ..:||.:|...|....
Mouse   936 TDMVIETKFG-------LLVSYDLKYSVRVKVPHNYYKHMCGLCGDYNDDPKNDFQKSDGSQAAS 993

  Fly   838 STT-----------SSGLPKWPTTR-----------TLEKKKQQSKSLPSLSTISNFHFEKSNFH 880
            |..           ||..|: |:.:           ||| ||.:.|....|.|...
Mouse   994 SNELGDSWEKAVPGSSCTPR-PSCKPGQACSPKCYPTLE-KKYRGKEFCGLITSPT--------- 1047

  Fly   881 GCDCTCQLELGRDSCICECNFKESTSDVSTSRSNQPLPTKLHSVKDNAPHSLTNANPESLTSKDL 945
            |....|...|.....:..|.|     |:.....||       |:..::.|:..:|         .
Mouse  1048 GPLAACHKLLDPQGPLQSCVF-----DLCLGGGNQ-------SILCSSIHAYVSA---------C 1091

  Fly   946 TTKGNGVTDNKITTLSKL-----SSDNVCECTCLLE--------QGNDSCTCNCMTDTNSIDESI 997
            ...|..|...:..|...:     |...||..||.|:        |....|:..|..||:.: :||
Mouse  1092 QAAGGTVKPWRNQTFCPMECPPHSHYEVCADTCSLDCSAITTPMQCLTPCSEGCECDTDFL-QSI 1155

  Fly   998 LTASQIVSSEDLQYSSNPPSYKSTQENTNTKGKNKNLSTLLQ------ISSTGPYQIYQSEIGNQ 1056
            .|.   |..|......|...|:..:            |.|::      :...|...:.|......
Mouse  1156 TTC---VPMEKCGCHYNGVYYEPEE------------SVLIENCQQHCVCQPGKGMMCQDHSCKP 1205

  Fly  1057 SQYVPPSSTLFSDITK---ISNTDKDHPTLDEEENISKSPLHLSTTSSSLPKIQITGVSHLPFLS 1118
            .|...||..:.:.:||   ...|.:...|..|::  .|.....:..|    |..:.|..|.....
Mouse  1206 GQVCEPSGGVLTCVTKDPCQGVTCRSQETCTEKD--GKGVCRANYES----KCWVWGDPHYHSFD 1264

  Fly  1119 TISNIKFEQSSFHGCDCTCQLEIGKDSCICECNLKESTSEGLKSVTASSLYIYLPQSSTTAHSLL 1183
            .::      ::|||   ||...:....|      ..:.:|||           .|.|..|.|...
Mouse  1265 GLN------TNFHG---TCSYLMAGTGC------PGTGAEGL-----------TPFSVITKHESQ 1303

  Fly  1184 TD 1185
            :|
Mouse  1304 SD 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
9530053A07Rik	NP_001158127.1	VWD	56..212	CDD:278521
		C8	257..326	CDD:214843
		TIL	329..383	CDD:280072
		VWD	448..598	CDD:278521	10/34 (29%)
		C8	644..714	CDD:285899	13/69 (19%)
		TIL	718..771	CDD:280072	7/52 (13%)
		VWC	773..827	CDD:302663	6/53 (11%)
		VWD	828..988	CDD:214566	35/181 (19%)
		C8	1033..1108	CDD:214843	18/104 (17%)
		TIL	1111..1164	CDD:280072	16/56 (29%)
		VWC	1166..1219	CDD:302663	9/64 (14%)
		VWD	1252..1411	CDD:278521	16/80 (20%)
		C8	1450..1525	CDD:214843
		TIL	1529..1583	CDD:280072
		VWD	1651..1802	CDD:278521
		C8	1839..1913	CDD:214843
		TIL	1916..1969	CDD:280072
		VWD	2039..2179	CDD:278521
		C8	2219..2294	CDD:214843
		TIL	2297..2350	CDD:280072
		VWC	2352..2404	CDD:302663
		VWD	2404..2558	CDD:295339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900