DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and Kcp

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	XP_038964921.1	Gene:	Kcp / 296952	RGDID:	1561119	Length:	1671	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	65/312 - (20%)
Similarity:	97/312 - (31%)	Gaps:	82/312 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   745 EPVKTHDVCECTCLLEQGNDSC------------------TCNCMTDFISTSIQISSTGPDQISQ 791
            |||.:.|.|. :|....|:..|                  .|..:.|.....:|..:|....|..
  Rat   416 EPVGSQDPCS-SCHCANGSVQCEPLPCPPAPCRYPGRIPGQCCPVCDVPCPPVQAVNTRDMNIGA 479

  Fly   792 NKMGNQSQSVPLLNTEFSDLMKISTTYKMHQTQNDIEKLSKSPPVLS---TTSSGLPKWPTTRTL 853
            .:        ||.:...:...........:..:|   :.::||||.:   ..||..|.....|:|
  Rat   480 RR--------PLPSKRMAAAFGAPARLVKYPVRN---RTARSPPVSTLPPAPSSAQPVCSMVRSL 533

  Fly   854 EKKKQQSK-SLPSLSTISNFHFEKSNFHGCDCTC---QLELGRDSCICECNFKESTSDVSTSRSN 914
            .:....|: :.|.|...:.          .:|.|   ...|...:.|.......:..|...|..:
  Rat   534 LRGSSGSQMTSPVLPVPAK----------TECLCAGLHFALQYPANILPSRPVSAQPDPVFSGFD 588

  Fly   915 QPLPTKLHSVKDNAPHSLTNANP--ESLTSKDLT-TKGNGVTDNKITTLSKLSSDNVCECTCLLE 976
            ||..|.|       || |....|  ||.|...|. :.|...||          .|:.|: ||..|
  Rat   589 QPTLTSL-------PH-LGACCPSCESCTYHGLVYSNGQNFTD----------VDSPCQ-TCYCE 634

  Fly   977 QGNDSCT-CNCMTDT------------NSIDESILTASQIVSSEDLQYSSNP 1015
            .|...|: .||.:.|            ....:.||.|...|..|...:..:|
  Rat   635 DGTVRCSVINCPSLTCAKPQNGPGQCCPKCPDCILEAQMFVDGERFPHPRDP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
Kcp	XP_038964921.1	VWC	227..281	CDD:278520
		VWC	285..341	CDD:327433
		VWC	405..460	CDD:327433	9/44 (20%)
		VWC	608..664	CDD:327433	15/66 (23%)
		VWC	725..781	CDD:327433
		VWC	1022..1078	CDD:327433
		VWC	1139..1204	CDD:327433
		VWC	<1223..1264	CDD:327433
		VWC	1271..1328	CDD:327433
		VWD	1335..1484	CDD:395046
		C8	1527..1599	CDD:214843
		TIL	1610..1663	CDD:410995
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900