DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and Otog

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_001099732.1	Gene:	Otog / 292918	RGDID:	1306610	Length:	2902	Species:	Rattus norvegicus

Alignment Length:	1013	Identity:	208/1013 - (20%)
Similarity:	347/1013 - (34%)	Gaps:	294/1013 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  3290 HQTTEVPWTLSTSLSQS-----SSEAKNIFSSQSVNEDNISQE----DTRTPSISVPQSSTTANR 3345
            |...:|.|..|..|:.:     ..:.:...:|.:.......|.    |.|||.| .|......|:
  Rat  1176 HPVVDVTWFYSNCLTDTCGCSRGGDCECFCASVAAYAHQCCQHGVVIDWRTPRI-CPYDCDFFNK 1239

  Fly  3346 -----------LLTGSSAEEPTAQEETSELSKSLPQLTAEESSSFQESSAEENQMTEVPWTLSTS 3399
                       ::.||:.....|.:....|.:: ..|...:.|||               .|:.:
  Rat  1240 ALGKGPYQLSSVMAGSALVAMRAVDGDIALVRA-EDLVPGDISSF---------------LLTAA 1288

  Fly  3400 LSQSSSKTKNIFSSQSVNEDNISQEDTRTPSISVPQ----------SSTTANR------LLTGSS 3448
            ||::.:...::.|.::.:..|.....|...||.:.:          :|.:.:|      |:...|
  Rat  1289 LSKAKAHDPDVVSLEAADRPNFYLHVTANGSIRLAKWRRDEAFHQHASFSLHRGTWQAGLVALES 1353

  Fly  3449 AEEPTAQEETSELSKSLPQLTTEESSSFQ----------ESSAEENQMTEVPWTLSTSLSQSSSK 3503
            ..:|.:..::|.|..:|  .|.|.:.:|:          :.|.....:.|..:....|....:.:
  Rat  1354 LAKPGSFLQSSGLKLAL--RTYEHTEAFRGGALFRLLDAKPSGAAYPICEWHYDACASPCFQTCR 1416

  Fly  3504 TKNIFSSQSVNE--------------DNISQ-----EDTRTPSISVPQSSTTANRLLTGSGAEEP 3549
            .....|.|.|..              |.::|     ||...|::..|:.
  Rat  1417 DPQAASCQDVPRVEGCVPVCPTPKVLDEVTQRCVYLEDCVEPALRGPKE---------------- 1465

  Fly  3550 TAQEETSELSKSLPQLTTEESSSFQESSAEENQMTEVPWTLSTSLSQSSSEAKNIFSSQSVNDDK 3614
            |...||....:.||            :::::.|:.:.|...||.:...
  Rat  1466 TLGNETLAPGQVLP------------TTSDKQQLPQEPPGASTHIPVL----------------- 1501

  Fly  3615 TSQEDTRTPSISVPQSSTTANR-LLTGSSAEEPTAQEETSEHSKSLPQLTTEESSSFQESSAEEH 3678
                |...|..|.|.....|.. .:....:.:||.|......:.:||...| |:::.:|.:|...
  Rat  1502 ----DPLAPLTSAPNPPMAATEGPVASPGSTQPTLQTSLGLTTSNLPAGHT-EATAREEGAASLL 1561

  Fly  3679 QTTEVPWTLSTSPSQSSSKTKNIFSSQSVNEDKISQEDTR-TLSISVSQSSTTANR--------L 3734
            .|:..|.:.|:.||...:.|..|.||        :.|.|: ||:.:.|.::|..:|        |
  Rat  1562 ATSPPPGSSSSLPSSLQTPTSGILSS--------TTETTKVTLTFAGSPNTTVTSRSPPVPRFPL 1618

  Fly  3735 LTGSIAEEQTAQEETSELSKSLPQLTTEESSSFQKSSAEENQMTEVPWTLSTSLSQSSSEAKNIF 3799
            :|.::         |.....|.|..||....|:..||..........|..::..|..|:...|:
  Rat  1619 MTKAV---------TVPSHDSFPVKTTPLRPSWSLSSRPTTSPGVTSWPPTSLGSHLSTVVTNV- 1673

  Fly  3800 SSQSVNDDKTSQEDTRTPSISVPQSSTTANSLLTGSSAEEQTAQEETSE--LSKSLPQLTTEESS 3862
                     |::.:|   |:||...||.:      ||....||....:.  ::|.|     |.:|
  Rat  1674 ---------TNKTET---SLSVLAQSTKS------SSQPLSTAYRAPASPLVTKGL-----EGAS 1715

  Fly  3863 SFQKSSAEEHQTTEVPWTLSTSPSQSSSKTKNIFSSQSVNEDKISQEDTRTLS---ISVSQSSTT 3924
            :.:|..|...|.||:|    .||..||:.......:|...    :...:..||   :.....||.
  Rat  1716 ATEKGDAGHSQLTELP----VSPPPSSAPIDLPHPAQHTT----TAPGSPALSPGILGAGSPSTG 1772

  Fly  3925 ANRLLTGSIAEEQTAQ---------EETS----ELSKSLPQLT--------TEESSSFQKSSAEE 3968
            |:.|.|.::|..:|.:         .:||    ::..|.|..|        |.....:..:||
  Rat  1773 AHGLGTTALASLETTRPPHLLSGLPPDTSLPLAKVGTSAPVATPASKGYVPTPPPQHWATTSA-- 1835

  Fly  3969 NQMTEVPWTLST-SLSQSSSEAKNIFSSQIVNEDKTSQEDT------RTPS-------------I 4013
            ..||..|.|.:| ||:.....|        |.|...|...|      .|||             :
  Rat  1836 TAMTVTPLTQTTLSLTAPLMSA--------VEEQAHSPSPTAPHITAMTPSFGASAGTAGVPPMV 1892

  Fly  4014 SV-PQSSTTANSLLTGSSAEEQTA---------QEETSELSKSLPQLTTEESSSFQKSSAEENQM 4068
            || ||.|||..:.:........|.         .|.|..:|.::..|.||         ||..|.
  Rat  1893 SVAPQKSTTQRAAILSKKVSPPTLISDSVQGGFTELTPTVSHTVAPLVTE---------AEGPQA 1948

  Fly  4069 TEVPWTVST-SLSQSSSKTKNIFSSQSVNEDKTSQEDTRTLSISVPQSIATANSLLTGSSAEEQT 4132
            ..||...:| |||:.|::|             .|:|....|   :|| :|.|:....|...:|..
  Rat  1949 GTVPLVPTTHSLSRVSART-------------ASREGPLVL---LPQ-LAEAHGTPAGLQPQEDL 1996

  Fly  4133 AQEETSEDS-KSLPQLTTEESSSFQESSAE-ENQTTEV 4168
            .::.|:|.: :|.|      :.|..|.|.| |..|:.:
  Rat  1997 VRQATTEQTGRSAP------AQSIAEGSMEAEGNTSAI 2028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
Otog	NP_001099732.1	VWD	143..293	CDD:278521
		C8	339..403	CDD:285899
		TIL	417..465	CDD:280072
		VWC	467..>502	CDD:302663
		VWD	505..660	CDD:278521
		C8	700..761	CDD:285899
		TIL	771..835	CDD:280072
		TIL	875..937	CDD:280072
		VWD	968..1122	CDD:214566
		C8	1157..1231	CDD:214843	12/55 (22%)
		Fascin	<1296..1387	CDD:304938	16/92 (17%)
		VWD	2089..2243	CDD:278521
		C8	2279..2347	CDD:214843
		TIL	2350..2411	CDD:280072
		CT	2819..2901	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900