DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and Sspo

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	XP_017177063.1	Gene:	Sspo / 243369	MGIID:	2674311	Length:	5197	Species:	Mus musculus

Alignment Length:	399	Identity:	71/399 - (17%)
Similarity:	134/399 - (33%)	Gaps:	102/399 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   929 PHSLTNANPESLTSKD----------LTTKGNGVTDNKITTLSKLSSDNVCECTCLLEQGNDSCT 983
            |..|.|.:|:.|.:.|          ::.:.:.|....:.|:.  ..|.|.:|....::|...|:
Mouse  1507 PALLCNGHPDCLDAADEESCLGPVSCISGEVSCVDGTCVRTIQ--LCDGVWDCPDGADEGPSHCS 1569

  Fly   984 CNCM----------TDTNSIDESILTASQIVSSED-------LQYSSN-----PPSYKSTQENTN 1026
            ...:          ..|:|:|    ||...|.|..       |::..|     |..::..||...
Mouse  1570 LPSLPTPPGGIGQNPSTSSLD----TAPSPVGSTSPASPCSLLEFQCNSGECTPRGWRCDQEEDC 1630

  Fly  1027 TKGKNKNLSTLLQISSTGPYQIYQSEIGNQSQYVPPSSTLFSDITKISNTDKDHPTLDEEENISK 1091
            |.|.:       ::...||..:||....:....|.|.. |...:|:..:...:.|.:.||::.|.
Mouse  1631 TDGSD-------ELDCGGPCMLYQVPCAHSPHCVSPGQ-LCDGVTQCPDGSDEDPDVCEEQSASG 1687

  Fly  1092 SPLHLSTTSSSLPKIQITGVSHLPFLSTISNIKFEQSSFHGCDCTCQLEIGKDSCICECNLKEST 1156
            .   .:.|.:..|:......:.:.||..             ||       |..    :|.|.:.|
Mouse  1688 G---ANRTGAPCPEFSCPDGTCIDFLLV-------------CD-------GNP----DCELADET 1725

  Fly  1157 SEGLKSVTA---SSLYIYLPQSSTTAHSLLTDLSAENQTNQEETSELSESLPQLTTEESSSFQES 1218
            ...|.....   .|...:.|.|.|..    :...:.|:.....:.::.::.|.|..:..:.|.|:
Mouse  1726 EPSLDEQGCGAWGSWGPWAPCSQTCG----SGTRSRNRNCSTSSLQVLQNCPGLQHQSQACFTEA 1786

  Fly  1219 SAEENQMTEVPWTLTTSLSQSSSKTKNIFSSLSVNEDNISQEDTRTLSISVPQSIATANSLLTGS 1283
            ...:.:.:.  |:..:..|:....|                 .||......||:.....:||.||
Mouse  1787 CPVDGEWSS--WSPWSPCSEPCGGT-----------------TTRHRQCRPPQNGGQDCALLPGS 1832

  Fly  1284 SAEEHTAQE 1292
            :   |:.::
Mouse  1833 T---HSTRQ 1838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
Sspo	XP_017177063.1	VWD	229..378	CDD:214566
		C8	434..505	CDD:370094
		TIL	509..564	CDD:366828
		VWD	593..753	CDD:214566
		C8	791..863	CDD:214843
		TIL	866..919	CDD:366828
		VWD	1054..1201	CDD:365869
		C8	1245..1311	CDD:370094
		TIL	1315..1371	CDD:366828
		LDLa	1416..1451	CDD:238060
		LDLa	1456..1490	CDD:238060
		LDLa	1492..1526	CDD:238060	6/18 (33%)
		LDLa	1532..1563	CDD:197566	5/32 (16%)
		Ldl_recept_a	1603..1639	CDD:365841	7/42 (17%)
		TSP1	1737..1788	CDD:214559	9/54 (17%)
		TIL	1857..1908	CDD:366828
		TSP1	1952..2005	CDD:214559
		FA58C	<2142..2262	CDD:330301
		LDLa	2275..2309	CDD:238060
		LDLa	2414..2448	CDD:238060
		LDLa	2471..2505	CDD:238060
		TSP1	2565..2617	CDD:214559
		TIL	2640..2682	CDD:366828
		TSP1	2725..2774	CDD:214559
		TSP_1	2841..2889	CDD:365867
		TIL	2893..2952	CDD:366828
		VWC_out	2954..3001	CDD:214565
		TSP1	2994..3045	CDD:214559
		TIL	3097..3149	CDD:366828
		TSP1	3193..3256	CDD:214559
		TSP1	3262..3314	CDD:214559
		TIL	3322..3372	CDD:366828
		TSP1	3418..>3458	CDD:214559
		TSP1	3482..3526	CDD:214559
		TIL	3536..3592	CDD:366828
		TSP1	3655..3699	CDD:214559
		TSP1	3832..3884	CDD:214559
		TSP1	3901..3949	CDD:214559
		TSP1	3967..4020	CDD:214559
		TSP1	4025..4077	CDD:214559
		TIL	4080..4135	CDD:366828
		TSP1	4180..4230	CDD:214559
		TSP1	4274..4325	CDD:214559
		TSP1	4389..4440	CDD:214559
		TIL	4444..4499	CDD:366828
		TSP1	4639..4687	CDD:214559
		TIL	4701..4747	CDD:366828
		TSP1	4791..4840	CDD:214559
		TIL	4842..4896	CDD:366828
		TIL	4948..5006	CDD:366828
		VWC	5008..5063	CDD:327433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900