DRSC/TRiP Functional Genomics Resources

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Protein Alignment Muc14A and Vwf

DIOPT Version :9

Sequence 1:NP_727928.3 Gene:Muc14A / 318097 FlyBaseID:FBgn0052580 Length:16223 Species:Drosophila melanogaster
Sequence 2:NP_035838.3 Gene:Vwf / 22371 MGIID:98941 Length:2813 Species:Mus musculus


Alignment Length:1006 Identity:169/1006 - (16%)
Similarity:313/1006 - (31%) Gaps:340/1006 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   323 LQMEKTPI----IRAKINLSSSDSTSTCELCSETLDETTNPFDSAETCEECVSLASNIFEEYTES 383
            |:..|.|.    |.::|..:.|...||.|:...||.:.....|..|        ||:|       
Mouse  1331 LKARKRPSELRRITSQIKYTGSQVASTSEVLKYTLFQIFGKIDRPE--------ASHI------- 1380

  Fly   384 NDEFLSSSSEEACEECSDIV------------------SPSASIKYPISIYNTTTMGSTIL---- 426
              ..|.::|:|......::|                  .|.||:|....|..........|    
Mouse  1381 --TLLLTASQEPPRMARNLVRYVQGLKKKKVIVIPVGIGPHASLKQIRLIEKQAPENKAFLLSGV 1443

  Fly   427 ----ERTIIIFGYFTEIITMIIFEFETITFSDAPEPNSDITGYTSTECIKCSELTTTVPIETTIE 487
                :|...|..|..::.            .:||.|         |:..:.:.:|.:..|     
Mouse  1444 DELEQRRDEIVSYLCDLA------------PEAPAP---------TQPPQVAHVTVSPGI----- 1482

  Fly   488 RTKLSETPLQKLQFSTPKKSTNRFASVLQLNAVTDSSIKVLN---TKTDQFDTEEETSLSEFLPE 549
                       ...|:|  ...|.:.||.:..|.:.|.:|..   .|:.:| .||.....:..|:
Mouse  1483 -----------AGISSP--GPKRKSMVLDVVFVLEGSDEVGEANFNKSKEF-VEEVIQRMDVSPD 1533

  Fly   550 WPTVLGSSLQFS-TIETQPSTNNGQ-----LTHT--------EKTTLSKSINHIKHHKINLGQNA 600
            ...:  |.||:| |:..:.:.|..|     |.|.        .:|...:::.::..|..:..|..
Mouse  1534 ATRI--SVLQYSYTVTMEYAFNGAQSKEEVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGD 1596

  Fly   601 E--------------AASHFNIQPGALHTISTTGGYHPTVKK-------------KQSETLPLLS 638
            .              |:......||.:..:....|.|..:::             :..||||..:
Mouse  1597 RVEAPNLVYMVTGNPASDEIKRLPGDIQVVPIGVGPHANMQELERISRPIAPIFIRDFETLPREA 1661

  Fly   639 TKSISLNMC--------------DCTCKLEIAKDSCICECNLKKSTSDISKGVTASASNQSLPTE 689
            ...:....|              ||:..|::                     |.....:.|||..
Mouse  1662 PDLVLQTCCSKEGLQLPTLPPLPDCSQPLDV---------------------VLLLDGSSSLPES 1705

  Fly   690 TNRKLHSMKDYAPNGTSLLTNASPEPF----------TIDDVTYKGNLAGKKTTMPSELSSLKKI 744
            :..|   ||.:|   .:.::.|:..|.          :|:.:....|:..:|..:.| |..|.:.
Mouse  1706 SFDK---MKSFA---KAFISKANIGPHLTQVSVIQYGSINTIDVPWNVVQEKAHLQS-LVDLMQQ 1763

  Fly   745 E--PVKTHD-----VCECTCLLEQGNDSCTCNCMTDFISTSIQISSTGPDQISQNKMGNQSQSVP 802
            |  |.:..|     |...|..:.......:...:...:.||:....|..|....|::.       
Mouse  1764 EGGPSQIGDALAFAVRYVTSQIHGARPGASKAVVIIIMDTSLDPVDTAADAARSNRVA------- 1821

  Fly   803 LLNTEFSDLMKISTTYKMHQTQNDIEKLSKSPPVLSTTSSGLPKWPTTRTLEKKKQQSKSLPSLS 867
                    :..:....:..:.|   .::...|...|..              .|.||.:.|.:::
Mouse  1822 --------VFPVGVGDRYDEAQ---LRILAGPGASSNV--------------VKLQQVEDLSTMA 1861

  Fly   868 TISNFHFEK--SNFHGCDCTCQLELGRDSCICECNFKESTSDVSTSRSNQPLPTKLHSVKDNAPH 930
            |:.|..|.|  |.|.|.            |:.|...::...||.|      ||.:.|:|      
Mouse  1862 TLGNSFFHKLCSGFSGV------------CVDEDGNEKRPGDVWT------LPDQCHTV------ 1902

  Fly   931 SLTNANPESLTSKDLTTKGNGVTDNKITTLSKLSSDNVCECTCLLEQGNDSCTCNCMTDTNSIDE 995
             ...||.::|.........:|...:...:.|.:..:..|.|..       :|.|.|   |.|...
Mouse  1903 -TCLANGQTLLQSHRVNCDHGPRPSCANSQSPVRVEETCGCRW-------TCPCVC---TGSSTR 1956

  Fly   996 SILT-----------ASQIV---SSEDLQY-----SSNPPSYKSTQENTNTK--GKNKNLSTLLQ 1039
            .|:|           .|.::   ..:||:.     :.:|.:.::..::...|  |.:..|.:.::
Mouse  1957 HIVTFDGQNFKLTGSCSYVIFQNKEQDLEVLLHNGACSPGAKQACMKSIEIKHAGVSAELHSNME 2021

  Fly  1040 ISSTG--------------------PYQIYQSEIGNQSQYVPPSSTLFSDITKISNTDKDHPT-- 1082
            ::..|                    .|::..:.:|:...|.|.::.....::..:...|.|..  
Mouse  2022 MAVDGRLVLAPYVGENMEVSIYGAIMYEVRFTHLGHILTYTPQNNEFQLQLSPKTFASKMHGLCG 2086

  Fly  1083 LDEEENISKSPLHLST-------------------TSSSLPKIQ--ITGVSHLPFLSTISNIKFE 1126
            :.:|...:...|...|                   |..::|:.|  ::..||...|.:.|..:..
Mouse  2087 ICDENGANDFTLRDGTVTTDWKRLVQEWTVQQPGYTCQAVPEEQCPVSDSSHCQVLLSASFAECH 2151

  Fly  1127 Q----SSFHGCDCTCQLEIGKDSC----ICE 1149
            :    ::||   ..||    :|||    :||
Mouse  2152 KVIAPATFH---TICQ----QDSCHQERVCE 2175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc14ANP_727928.3 PRK14949 <11377..11776 CDD:237863
PRK08581 11922..>12215 CDD:236304
PRK14949 <13679..14114 CDD:237863
PRK14949 <14663..15055 CDD:237863
VwfNP_035838.3 VWD 35..179 CDD:278521
C8 218..292 CDD:214843
TIL 295..348 CDD:280072
VWC 350..>394 CDD:302663
VWD 377..540 CDD:214566
C8 580..648 CDD:285899
TIL 652..707 CDD:280072
Amino-terminal 764..787
E1 788..833
CX 826..853
VWD 856..1011 CDD:214566
C8 1053..1127 CDD:214843
TIL 1146..1196 CDD:280072
VWA_N2 1198..1276 CDD:292782
VWA 1277..1449 CDD:214621 26/134 (19%)
VWA 1498..1658 CDD:278519 27/162 (17%)
VWA 1691..1860 CDD:278519 33/228 (14%)
VWD 1950..2102 CDD:278521 21/154 (14%)
C8 2136..2199 CDD:285899 13/47 (28%)
TIL 2203..2254 CDD:280072
E2 2216..2261
VWC 2257..2321 CDD:214564
VWC 2431..2494 CDD:214564
Cell attachment site. /evidence=ECO:0000250 2507..2509
VWC 2582..2644 CDD:302663
CT 2727..2808 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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