DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc14A and T09D3.3

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_001343619.1	Gene:	T09D3.3 / 188324	WormBaseID:	WBGene00020384	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	773	Identity:	153/773 - (19%)
Similarity:	264/773 - (34%)	Gaps:	167/773 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  6320 IFSSQSVNEDKTSQEDTRTLPISVPQSIATTNSLLTGSSAEEQTAQEETSEHSKSLPQLTTEESS 6384
            ||.:.|:|..|..|:.:....:|   :||                 |:.|..:..        .|
Worm    11 IFFAASINAQKVEQDHSVVNRVS---NIA-----------------EKYSNWALG--------KS 47

  Fly  6385 SFQESSAEENQMTEVPWTLSTSLSQSSLQAKNIFS----SPNLNEDNISQEDTRTLPISVPQSIA 6445
            .::..:....|:|:|.   |...:.::...|..|.    .|.|....::..:|...||.:..:
Worm    48 DYRNGNLNNFQVTQVQ---SPPRNYNTAPVKRFFHQVRIQPPLIIKPVTYSETSYQPIDIYST-- 107

  Fly  6446 TANSLLTEPKNIFSSQSLNEDNISQEDTRTPSISVSQSSTTANRLLTGSIAEEQTAQEETSEHSK 6510
            |...:||.|.  :.|:..:....:::..|:|.....|.|....|||...:...|::...||..|.
Worm   108 TQTPILTTPP--YPSRISHFPTENRQIFRSPVRQHYQPSPNFPRLLETEVPVSQSSPMFTSNSSL 170

  Fly  6511 SLPQLTTEESSSFQESSAEE--NQTTEVPWTLSTSPSQSSSKTKNIFSSPSLNEDNISQEDTRTL 6573
            ..|.:    |.:|..|...:  |...:.| .:.|:|       .|:..||.:   :|:......:
Worm   171 LPPHM----SQNFGSSILTQLLNPILQEP-NIPTAP-------PNLQISPQM---HINPNFPTLV 220

  Fly  6574 PISVPQSIATANSLLTGSSAEEQTAQEETSEHSK----SLPQLTTEESSSFQESSAEENQMTEVP 6634
            |:.:||.:..           |.|.:|.....||    .:|:...|....|.::|..
Worm   221 PLPIPQPVVL-----------EPTKEEVMKIASKKNLYGMPRFPIEPHRGFFQASMS-------- 266

  Fly  6635 WTLSTSLSQSSSEPKNIFSSQSLNEDNISQEDTRTLPISV-PQSIATANSL-LTGSSAEEQTAQE 6697
             .:.........||:..|::           .|.|:..|| |.|.:..:.| |....|.:.....
Worm   267 -CMDGWCGNECCEPRRPFAA-----------PTTTIQASVLPGSPSPPHPLVLVVHPAPQAQCSP 319

  Fly  6698 ETSEH--SKSLPQLTTEESSSFQESSAEENQTTEVPWTLSTSPSQSSSKTKNIFSSPSLNEDNIS 6760
            ....|  .:.:.:|.....|.|.....|.          |..|.          ..||.:.|.:
Worm   320 ACQPHCSQQCVARLQYMHESQFYNHILEP----------SCRPD----------CMPSCHVDCL- 363

  Fly  6761 QEDTRTLPISVPQSIATANSL----LTGSSAEEQTAQEETSERSKSLPQLTTEESSSFQESSAEE 6821
                    |..||.: ..||.    |.|   ..|.|......|   .|.|.....|:....|:||
Worm   364 --------IIPPQQV-RCNSFNCQCLAG---YVQCAAFTCCMR---YPNLAARMKSNVMAKSSEE 413

  Fly  6822 NQTTNQSVNEDKTSQEDTRTLSISVPQSIATTNSLLTGSSAEEQTAQEETSEDSKSLPQLTTEES 6886
                     |...|:|..:...||. :.:.|.|.:..|....:       .|:..|.|.:.....
Worm   414 ---------EANVSEEGKQDNEISY-RRMYTPNRMRAGKGKYD-------IENVTSPPVIRPSYW 461

  Fly  6887 SSFQESSAEENQTTEVPWTPSTSPSQSSSKTKNIFSSQSVNEDKTSQEDTRTLSISVPQSIATTN 6951
            :..:..|.:|.:||....||...|:.:|:.|    |:.::....:|...|.|.:..||.:..||.
Worm   462 TKHRVKSTKEPKTTIFTTTPVPCPTTTSTTT----SATTLVPTTSSSTTTTTTTTPVPVTSTTTE 522

  Fly  6952 SLLTGSSAEEQTAQEETSEHSKSLPQLTTEESSSFQESSAEENQMTEVP----WTLSTSLSQSSS 7012
            ...|..:....|:...|...:.|.|::....:..:.:...:.|::..:|    ||:...:..||.
Worm   523 PTTTTYTTSTSTSTTTTLPPTTSTPKIVVNLTPIYPDMLMKANKVPMIPAYGIWTIPPHVPPSSK 587

  Fly  7013 KTKNIFS--SQSVNEDKTSQEDTRTLSISVPQSIATTNSLLTGSSAEEQTAQEETSED 7068
            :..|..|  ..|..|.:.|..|.|...:     |.:.|.|...|...:...:|:.::|
Worm   588 EFDNPLSGIKTSPTEKRNSIGDIRGRHV-----IRSENFLDVLSELAQVKLKEDITDD 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
T09D3.3	NP_001343619.1	EBV-NA3	<86..323	CDD:332796	56/286 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900