DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc14A and F19C6.3

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_509679.1	Gene:	F19C6.3 / 184675	WormBaseID:	WBGene00008952	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	62/354 - (17%)
Similarity:	118/354 - (33%)	Gaps:	122/354 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 NKSNYRTLFLNTILSWRNGVFNLFPAW---NYNL------FWVQNPQIECEHIQTLSSTKRRIVD 161
            ::|:|       ||:....:.::..:|   |::|      |..||             ::|||
Worm    21 DRSSY-------ILAHYMNLLSIGESWILTNFDLDSNGTFFLAQN-------------SERRI-- 63

  Fly   162 YKLWKSKELKMANIGFRLNSKILRFFLLILRRKISLLNTPRGLKKKSMEKAEFFEYLSATETPEL 226
                        ..||:  :|.|...|.|.:.:|         :..:.||....:
Worm    64 ------------EFGFK--NKTLYMVLPISKSRI---------QSNNWEKRYVID---------- 95

  Fly   227 FDNLDHLENNRKLNFASQEVLEIHNQANFKDKHIYVWKNLTRYISN-----DNNLNHTVTKVNIS 286
            ||::..:..|.:|..            .|::.||:|:.......|:     ...|||  ..::|.
Worm    96 FDSIGKIGRNLELII------------TFQNNHIHVYNGCDEVYSDFEPHLQLTLNH--PSLHIV 146

  Fly   287 DYQSKNKKSINPIEDILPSPFTKTYNLGRFARNQGLLQM---EKTPIIRAKINLSSSDSTSTCEL 348
            |    |.|...|.:.::.|    .:.:|:..::.|:.:.   ..|..|......|:.|:.:  |:
Worm   147 D----NWKGPEPTQFLIGS----GWPIGQKCKHDGVKKKYADAYTEKIERNYEPSAIDAIN--EI 201

  Fly   349 CSETLDETTNPFDSAE--------------TCEECVSL-ASNIFEEYTE-----------SNDEF 387
            ..||:.:....||..:              .|..|..: ..|:..:..:           ..|:.
Worm   202 FFETVVQVPPGFDGCKINNALLNINETKTVNCNTCTCVDRDNVVCQAVDCPAVTCTHPMIRKDDC 266

  Fly   388 LSSSSEEACEECSDIVSPSASIKYPISIY 416
            ..|..|:...|...|.:|...:.:|...|
Worm   267 CPSCGEQCFYESHKIANPHGEVFWPGDCY 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
F19C6.3	NP_509679.1	VWC	216..270	CDD:214564	4/53 (8%)
		EGF_3	346..375	CDD:289699
		EGF_CA	377..416	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900