DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc14A and Vwf

DIOPT Version :9

Sequence 1:	NP_727928.3	Gene:	Muc14A / 318097	FlyBaseID:	FBgn0052580	Length:	16223	Species:	Drosophila melanogaster
Sequence 2:	NP_446341.1	Gene:	Vwf / 116669	RGDID:	621759	Length:	2812	Species:	Rattus norvegicus

Alignment Length:	1276	Identity:	228/1276 - (17%)
Similarity:	370/1276 - (28%)	Gaps:	472/1276 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LKMANIGFRLNS-KILRFFLLILRRKISLLNTPRGLKKKSMEKAEFFEYLSATETPELFDNLDHL 233
            :..||||..|.. .::::      ..|:.::.|..:.::........:.:.....|....|
  Rat  1718 ISKANIGPHLTQVSVIQY------GSINTIDVPWNVAQEKAYLQSLVDLMQQEGGPSQIGN---- 1772

  Fly   234 ENNRKLNFASQEVL-EIHNQANFKDKHIYVWKNLTRYISNDNNLNHTVTKVNISDYQSKNKKSIN 297
                .|.||.:.|. :||.......|.:.:       |..|.:|:...|.|   |....|:.::.
  Rat  1773 ----ALAFAVRYVTSQIHGARPGASKAVVM-------IIMDTSLDSVDTAV---DAARSNRVAVF 1823

  Fly   298 PIE----------DILPSPFTKTYNLGRFARNQGLLQMEKTPIIRAKINLSSSDSTSTCELCS-- 350
            ||.          .||..|...: |:.:..:.:.||.| .||           .::....|||
  Rat  1824 PIGVGDRYDEAQLRILAGPGASS-NVVKLQQVEDLLTM-VTP-----------GNSFFHRLCSGF 1875

  Fly   351 --ETLDETTN---PFD---SAETCEECVSLASNIFEEYTESNDEFLSSSSEEACE-----ECSDI 402
              ..:||..|   |.|   ..:.|.....||          |.:.|..|....|:     .||:.
  Rat  1876 SGVCVDEDGNEKRPGDVWTLPDQCHTVTCLA----------NGQTLLQSHRVNCDHGPRPSCSNS 1930

  Fly   403 VSPSASIKYPISIYNT----------TTMGSTILERTIIIFG----YFTEIITMIIF-----EFE 448
            .|       |:.:..|          .|..||   |.|:.|.    ..|...:.:||     :.|
  Rat  1931 QS-------PVRVEETCGCRWTCPCVCTGSST---RHIVTFDGQNFKLTGNCSYVIFQNKEQDLE 1985

  Fly   449 TITFSDAPEPNSDITGYTSTECIKCSELT---TTVPIETTIE-----------------RTKLSE 493
            .:..:.|..|.:..|      |:|..|:.   .:|.:.:.:|                 :..:..
  Rat  1986 VVLHNGACSPGAVQT------CMKTIEVKHAGLSVELRSDMEMAVNGRPVLAPYVGGNMQVSIYG 2044

  Fly   494 TPLQKLQFS--------TPKK-------STNRFAS-------VLQLNAVTDSSIKVLNTKTDQFD 536
            ..:.:::|:        ||:.       |...|||       :...|...|.:::         |
  Rat  2045 AIMYEVRFTHLGHTLTFTPQNNEFQLQLSPKTFASKMYGLCGICDENGANDFTLR---------D 2100

  Fly   537 TEEETSLSEFLPEWPTVLGSSLQFSTIETQPSTNNGQLTHTEKTTLSKSINHIKHHKINLGQNAE 601
            ....|.....:.||           |::...||  .|....|:..:|.|    .|.::.|..:.
  Rat  2101 GTVTTDWKRLIQEW-----------TVQQPGST--CQSVPEEQCPISDS----SHCQVLLSASF- 2147

  Fly   602 AASHFNIQPGALHTISTTGGYHPTVKKKQSETLP----LLSTKSI-----SLNMCDCTCKLEIAK 657
            |..|..|.|...|||......|   :::..|.:.    |..|..:     :.:.|..:|...:..
  Rat  2148 AECHKVIAPATFHTICQQDSCH---QERVCEVIASYAHLCRTNGVCVDWRTTDFCAMSCPPSLIY 2209

  Fly   658 DSC------ICECNLKKSTSDISKG--------------VTASASNQSLPTETNRKLHS-----M 697
            :.|      .|:.|........|:|              |...|..|.:..:..|  |.     :
  Rat  2210 NHCERGCPRYCDGNTSFCGDHPSEGCFCPQHQVLLEGSCVPEEACTQCVGDDGVR--HQFLETWV 2272

  Fly   698 KDYAP-------NGTSLLTNASPEPFTIDDVTYKGNLAGKKTTMPSELSSLKKIEPVKTHDVC-- 753
            .|:.|       :|..:...|.|.|           .|...|..|.|::.||     ::.|:|
  Rat  2273 PDHQPCQICMCLSGRKINCTAQPCP-----------TARAPTCGPCEVARLK-----QSADLCCP 2321

  Fly   754 --ECTCLLEQGNDSCTCN------CMTDFISTSIQISSTGPDQISQNKMGNQSQSVPLLNTEFSD 810
              ||.|      |...||      |     ...:|.:.|.|.:
  Rat  2322 EYECVC------DLVNCNLPPVPPC-----EGGLQPTLTNPGE---------------------- 2353

  Fly   811 LMKISTTYKMHQTQNDIEKLSKSPPVLSTTSSGLPKWPTTRTLEKKKQQSKSLPSLSTISNFHFE 875
               ...|:.....:.:.:::|.            |..|..||...:|.|.
  Rat  2354 ---CRPTFTCACRKEECKRVSP------------PSCPPHRTPTLRKTQC--------------- 2388

  Fly   876 KSNFHGCD---CTCQLELGRDSCICECNFKESTSDVSTSRSNQPLPTKLHSVKDNAPHSLTNANP 937
                  ||   |||       ||:                 |..|...|..:
  Rat  2389 ------CDEYECTC-------SCV-----------------NSTLSCPLGYL------------- 2410

  Fly   938 ESLTSKDLTTKGNGVTDNKITTLSKLSSDNVCEC---TCL-----------------LEQGNDSC 982
            .|.|:.|                        |.|   |||                 .|:|.|:|
  Rat  2411 ASATTND------------------------CGCTTTTCLPDKVCVHRGTVYPVGQFWEEGCDTC 2451

  Fly   983 TCNCMTDTNSIDESILTASQIVSSEDLQYSSNP------PSYKSTQENTNTKGKNKNLSTLLQIS 1041
            ||..|.||            :|.....|.|..|      |.:..........||....:..:..|
  Rat  2452 TCTDMEDT------------VVGLRVAQCSQKPCEDSCQPGFSYVLHEGECCGKCLPSACKVAGS 2504

  Fly  1042 STGPYQIYQSEIGNQSQYVPPSSTLFSDITKISNTDKDHPTLDEEENISKSPLHLST-------- 1098
            ..|........:|:| ..||.:..|.::..::.:.     ...::.|||...|.:.|
  Rat  2505 PRGDSLSSWKSVGSQ-WAVPENPCLINECVRVEDA-----VFVQQRNISCPQLAVPTCPTGFQLN 2563

  Fly  1099 --TSSSLPKIQITGVSHLPFLSTI----SNIKFEQSSFHGCDCTCQ--------LEIGKDSC-IC 1148
              ||:..|......|.......||    .::..:..:  .|.|..|        ||..|.:| .|
  Rat  2564 CETSACCPSCHCEPVEACLLNGTIIGPGKSVMVDLCT--TCRCIVQRGAIFRFKLECRKTTCEAC 2626

  Fly  1149 ECNLKESTSE----GLKSVTASSLYI------YLPQSSTTAHSLLTDLSAENQTNQEETSELSES 1203
            ....:|..|:    |....||.::.:      .|.|..|......:.|...|        |..|.
  Rat  2627 PVGYREEKSQSECCGRCLPTACTIQLRGGRVMTLKQDETFQDGCDSHLCRVN--------ERGEY 2683

  Fly  1204 LPQLTTEESSSFQESS--AEENQMTEVPWTLTTSLSQSSSK 1242
            :.:........|.|..  ||..::.::|.|...:..:...|
  Rat  2684 IWEKRVTGCPPFDERKCLAEGGKIVKIPGTCCDTCEEPDCK 2724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc14A	NP_727928.3	PRK14949	<11377..11776	CDD:237863
		PRK08581	11922..>12215	CDD:236304
		PRK14949	<13679..14114	CDD:237863
		PRK14949	<14663..15055	CDD:237863
Vwf	NP_446341.1	VWD	35..179	CDD:278521
		C8	218..292	CDD:214843
		TIL	295..348	CDD:280072
		VWD	377..540	CDD:214566
		C8	580..648	CDD:285899
		TIL	652..707	CDD:280072
		VWD	856..1011	CDD:214566
		C8	1053..1127	CDD:214843
		TIL	1146..1196	CDD:280072
		VWA_N2	1198..1276	CDD:292782
		VWA	1277..1449	CDD:214621
		VWA	1498..1658	CDD:278519
		VWA	1691..1862	CDD:278519	32/169 (19%)
		VWD	1950..2102	CDD:278521	28/169 (17%)
		C8	2136..2199	CDD:285899	14/70 (20%)
		TIL	2203..2254	CDD:280072	7/50 (14%)
		VWC	2257..2321	CDD:214564	16/81 (20%)
		VWC	2431..2494	CDD:214564	15/74 (20%)
		VWC	2581..2643	CDD:302663	13/63 (21%)
		CT	2726..2807	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900