DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32579 and CAPN2

DIOPT Version :9

Sequence 1:	NP_001259606.1	Gene:	CG32579 / 318096	FlyBaseID:	FBgn0052579	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001739.3	Gene:	CAPN2 / 824	HGNCID:	1479	Length:	700	Species:	Homo sapiens

Alignment Length:	124	Identity:	21/124 - (16%)
Similarity:	37/124 - (29%)	Gaps:	48/124 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 WRFVSICINW----------SLAYVYWMEESY---------------GYCAWTIGSILVPMVVTS 71
            |:...:..||          :....:||...|               ..|.:.:|
Human   356 WKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVG---------- 410

  Fly    72 VIYIHTLKSAHAGE-KRILERGVY------SNAVISYLFRDVYVLNYAFKYSLAKERDD 123
            :|..|..:....|| ...:..|:|      |.....:|.::.::.|      .|:||.|
Human   411 LIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTN------RARERSD 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32579	NP_001259606.1	XK-related	25..353	CDD:286853	21/124 (17%)
CAPN2	NP_001739.3	Peptidase_C2	46..342	CDD:306994
		Domain III	345..514		21/124 (17%)
		Calpain_III	363..507	CDD:307285	20/117 (17%)
		Linker	515..529
		Domain IV	530..700
		EFh_PEF_CAPN2	533..700	CDD:320074
		EF-hand motif	533..561	CDD:320074
		EF-hand motif	576..605	CDD:320074
		EF-hand motif	606..636	CDD:320074
		EF-hand motif	642..670	CDD:320074
		EF-hand motif	672..700	CDD:320074
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900