DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32579 and CAPN8

DIOPT Version :9

Sequence 1:	NP_001259606.1	Gene:	CG32579 / 318096	FlyBaseID:	FBgn0052579	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001137434.1	Gene:	CAPN8 / 388743	HGNCID:	1485	Length:	703	Species:	Homo sapiens

Alignment Length:	160	Identity:	33/160 - (20%)
Similarity:	53/160 - (33%)	Gaps:	61/160 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VLNYAFKYSLAKERDDKQAEIEYYQKLMTEECNVSFVRLFDSFLES------APQKILQLAILLQ 166
            :||.||         .|:.:|::      :..|::..|...|.|:|      ...:...|.:.:|
Human   559 LLNEAF---------SKRTDIKF------DGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQ 608

  Fly   167 STLEFTYYRHIALIVYFGNIAWCIQAYNHSNRLAQLDKHDIAAKGRFLQFLFLLCLTVIRFYFVV 231
            ..||               |.|... ||||   ..:|.|::....|...|         .....|
Human   609 KYLE---------------IYWETD-YNHS---GTIDAHEMRTALRKAGF---------TLNSQV 645

  Fly   232 SRTLCIAY------------VASIFPIETL 249
            .:|:.:.|            ||.:..:|||
Human   646 QQTIALRYACSKLGINFDSFVACMIRLETL 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32579	NP_001259606.1	XK-related	25..353	CDD:286853	33/160 (21%)
CAPN8	NP_001137434.1	Peptidase_C2	46..342	CDD:279042
		Calpain_III	356..509	CDD:279416
		Domain III	356..379
		EFh	580..635	CDD:238008	16/73 (22%)
		PTZ00183	618..>692	CDD:185503	16/71 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900