Protein Alignment Hexo2 and HEXB

DIOPT Version :10

• Sequence 1: NP_525081.1
• Gene: Hexo2 / 31808
• FlyBaseID: FBgn0041629
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_000512.2
• Gene: HEXB / 3074
• HGNCID: 4879
• Length: 556
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 181/596 - (30%)
• Similarity: 268/596 - (44%)
• Gaps: 138/596 - (23%)

  Fly    75 EIFESQRDCRLSCGKYGAIWPMP--------------------------TGKECTISHRRVR--- 110
            ::.|:.|...:|.....|:||:|                          .|..||:.....|
Human    38 QVAEAARAPSVSAKPGPALWPLPLLVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYH 102

  Fly   111 -----FDPWKVRFHVVAPGEAATQFLRETNRLFVSNLLKECIRNCTLETSKQILVRSTVANE-SL 169
                 |..|   .|..|..:|.||.                         :|:||..|:.:| ..
Human   103 GYIFGFYKW---HHEPAEFQAKTQV-------------------------QQLLVSITLQSECDA 139

  Fly   170 VLDWPTDESYALVVRTTETATFVDIQATTVYGARHAFETLSNLVTGSLSNGLLMVTTANITDRPA 234
            ..:..:||||.|:|:.....    ::|..|:||....||.|.||... |.|...:..:.|.|.|.
Human   140 FPNISSDESYTLLVKEPVAV----LKANRVWGALRGLETFSQLVYQD-SYGTFTINESTIIDSPR 199

  Fly   235 FSHRGVLLDTARNFVPLKFIRSTLDAMAASKLNVLHWHVVDTHSFPLEITRVPEMQRYGAYSSSQ 299
            |||||:|:||:|:::|:|.|..||||||.:|.||||||:||..|||.:....||:...|:||.|.
Human   200 FSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSH 264

  Fly   300 TYSRQDALNLVKYARLRGIRILIEIDGPSHAGNGWQWGPAAGLGNMSVCLNQSPWRRFCVQPPC- 363
            .|:..|...:::||||||||:|.|.|.|.|.   ..||.    |...:.            .||
Human   265 VYTPNDVRMVIEYARLRGIRVLPEFDTPGHT---LSWGK----GQKDLL------------TPCY 310

  Fly   364 ---------GQLNPLNDHMYAVLKEIFEDVAEVGAPEETLHMGGDEVFLPCWNNTDEIRDGMRAR 419
                     |.:||..:..|:.|...|::::|| .|::.:|:|||||...||.:..:|:|.||.:
Human   311 SRQNKLDSFGPINPTLNTTYSFLTTFFKEISEV-FPDQFIHLGGDEVEFKCWESNPKIQDFMRQK 374

  Fly   420 GYDLSEQSFLRLWSQFHQRNLNAWDEINERMYPGIKEPKSVIIWSSHLTNPRYIETYLPKERF-- 482
            |:.   ..|.:|.|.:.|:.|:....||          |..|:|.         |.:..|.:.
Human   375 GFG---TDFKKLESFYIQKVLDIIATIN----------KGSIVWQ---------EVFDDKAKLAP 417

  Fly   483 --IIQTWVES--QDALNRELLQRGYRLIVSTKNAWYLDHGFWGSTSYYNWRTVYS-SGMPVG--- 539
              |::.|.:|  .:.|:| :...|:.:|:|.  .||||...:|.    :||..|. ..:..|
Human   418 GTIVEVWKDSAYPEELSR-VTASGFPVILSA--PWYLDLISYGQ----DWRKYYKVEPLDFGGTQ 475

  Fly   540 RSKDQVLGGEVCMWSEYVDQNSLESRIWPRAGAAAERMWSNPKSSAL-LAQRRFYRYRERLLARG 603
            :.|...:|||.|:|.||||..:|..|:||||.|..||:||:.....: .|..|..|:|.|::.||
Human   476 KQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG 540

  Fly   604 IHADAVIPHWC 614
            |.|..:...:|
Human   541 IAAQPLYAGYC 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hexo2	NP_525081.1	Glyco_hydro_20b	93..212	CDD:446174	32/153 (21%)
		GH20_HexA_HexB-like	235..603	CDD:119332	133/388 (34%)
HEXB	NP_000512.2	Glycohydro_20b2	56..178	CDD:434261	32/153 (21%)
		GH20_HexA_HexB-like	200..540	CDD:119332	133/388 (34%)