Protein Alignment Hexo2 and HEXA

DIOPT Version :10

• Sequence 1: NP_525081.1
• Gene: Hexo2 / 31808
• FlyBaseID: FBgn0041629
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001305754.1
• Gene: HEXA / 3073
• HGNCID: 4878
• Length: 540
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 195/595 - (32%)
• Similarity: 267/595 - (44%)
• Gaps: 128/595 - (21%)

  Fly    38 DVGSDADAGSASRKWLCSRTDICTAEGEMVAGLQYAPEIFESQRDCRLSCGKYGAIWPMP--TGK 100
            ||.|.|..|       ||..|                |.|:..||.....|.    ||.|  ||
Human    49 DVSSAAQPG-------CSVLD----------------EAFQRYRDLLFGSGS----WPRPYLTG- 85

  Fly   101 ECTISHRRVRFDPWKVRFHVVAPGEAATQFLRETNRLFVSNLLKECIRNCTLETSKQILVRSTVA 165
                         |..:.:.|..|:..|   .|.|.|.||.:...|.:..|||:.
Human    86 -------------WPHQAYPVFLGKRHT---LEKNVLVVSVVTPGCNQLPTLESV---------- 124

  Fly   166 NESLVLDWPTDESYALVVRTTETATFVDIQATTVYGARHAFETLSNLVTGSLSNGLLMVTTANIT 230
                       |:|.|.:...:..    :.:.||:||....||.|.||..| :.|...:....|.
Human   125 -----------ENYTLTINDDQCL----LLSETVWGALRGLETFSQLVWKS-AEGTFFINKTEIE 173

  Fly   231 DRPAFSHRGVLLDTARNFVPLKFIRSTLDAMAASKLNVLHWHVVDTHSFPLEITRVPEMQRYGAY 295
            |.|.|.|||:||||:|:::||..|..|||.||.:||||.|||:||..|||.|....||:.|.|:|
Human   174 DFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSY 238

  Fly   296 SS-SQTYSRQDALNLVKYARLRGIRILIEIDGPSHAGNGWQWGPAAGL-GNMSVCLNQSPWRRFC 358
            :. :..|:.||...:::||||||||:|.|.|.|.|.   ..|||  |: |.::.|.:.|
Human   239 NPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHT---LSWGP--GIPGLLTPCYSGS------ 292

  Fly   359 VQPPCGQLNPLN---DHMYAVLKEIFEDVAEVGAPEETLHMGGDEVFLPCWNNTDEIRDGMRARG 420
              .|.|...|:|   ::.|..:...|.:|:.| .|:..||:|||||...||.:..||:|.||.:|
Human   293 --EPSGTFGPVNPSLNNTYEFMSTFFLEVSSV-FPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKG 354

  Fly   421 YDLSEQSFLRLWSQFHQRNLNAWDEINERMYPGIKEPKSVIIWSSHLTNPRYIETYLPKERFIIQ 485
            :.   :.|.:|.|.:.|..|:......          |..::|.....|...|:   |..  |||
Human   355 FG---EDFKQLESFYIQTLLDIVSSYG----------KGYVVWQEVFDNKVKIQ---PDT--IIQ 401

  Fly   486 TWVESQDA-LNREL---LQRGYRLIVSTKNAWYLDHGFWGSTSYYNWRTVY------SSGMPVGR 540
            .|.|.... ..:||   .:.|:|.::|.  .|||:...:|.    :|:..|      ..|.|  .
Human   402 VWREDIPVNYMKELELVTKAGFRALLSA--PWYLNRISYGP----DWKDFYIVEPLAFEGTP--E 458

  Fly   541 SKDQVLGGEVCMWSEYVDQNSLESRIWPRAGAAAERMWSNPKSSAL-LAQRRFYRYRERLLARGI 604
            .|..|:|||.|||.||||..:|..|:||||||.|||:|||..:|.| .|..|...:|..||.||:
Human   459 QKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGV 523

  Fly   605 HADAVIPHWC 614
            .|..:...:|
Human   524 QAQPLNVGFC 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hexo2	NP_525081.1	Glyco_hydro_20b	93..212	CDD:446174	28/120 (23%)
		GH20_HexA_HexB-like	235..603	CDD:119332	143/383 (37%)
HEXA	NP_001305754.1	Glycohydro_20b2	23..156	CDD:434261	41/175 (23%)
		GH20_HexA_HexB-like	178..522	CDD:119332	143/383 (37%)