DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hexo2 and hex-1

DIOPT Version :9

Sequence 1:	NP_525081.1	Gene:	Hexo2 / 31808	FlyBaseID:	FBgn0041629	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_508409.1	Gene:	hex-1 / 180533	WormBaseID:	WBGene00020509	Length:	555	Species:	Caenorhabditis elegans

Alignment Length:	574	Identity:	158/574 - (27%)
Similarity:	249/574 - (43%)	Gaps:	137/574 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 GAIWPMPT-----GKECTISHRRVRFD-------------------PWKVRFHVVAPGEAATQFL 131
            |.:||:|.     .|..||::.::..|                   .|...|    |.|..|
Worm    32 GGVWPLPKKIVYGSKNRTITYDKIGIDLGDKKDCDILLSMADNYMNKWLFPF----PVEMKT--- 89

  Fly   132 RETNRLFVSNLLKECIRNCTLETSKQILVRSTVANESLVLDWPT-------DESYALVVRTTETA 189
                                 ..::..::..||.:|.     |:       .|.|.|.|..||..
Worm    90 ---------------------GGTEDFIITVTVKDEC-----PSGPPVHGASEEYLLRVSLTEAV 128

  Fly   190 TFVDIQATTVYGARHAFETLSNLVTGSLSNGLLMVTTANITDRPAFSHRGVLLDTARNFVPLKFI 254
                |.|.||:||..|.|:||:||.....:....:.|..|.|:|.|..||:::|::|:|:.:..|
Worm   129 ----INAQTVWGALRAMESLSHLVFYDHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVI 189

  Fly   255 RSTLDAMAASKLNVLHWHVVDTHSFPLEITRVPEMQRYGAYSSSQTYSRQDALNLVKYARLRGIR 319
            :..|:.|:.:||||||||:||:.|||....:.||:...||||....|||:|..:::.:|||||||
Worm   190 KRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSPRHVYSREDIADVIAFARLRGIR 254

  Fly   320 ILIEIDGPSHAGNGWQWGPAAGLGNMSVCLNQSPWRRFCVQPPCGQLNPLNDHMYAVLKEIFEDV 384
            ::.|.|.|.|. :.|:    ...|.::.|.::.....|..    ..::|:|:..:..:.|..|:|
Worm   255 VIPEFDLPGHT-SSWR----GRKGFLTECFDEKGVETFLP----NLVDPMNEANFDFISEFLEEV 310

  Fly   385 AEVGAPEETLHMGGDEV---FLPCWNNTDEIRDGMRARGYD-----LSEQSFLRLWSQFHQRNLN 441
            .|. .|::.||:|||||   .:.||....:||..|..:|:.     |....|.:|:.......|.
Worm   311 TET-FPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLK 374

  Fly   442 A----WDEINERMYPGIKEPKSVI-IWSSHLTNPRYIETYLPKERFIIQTWVESQDALNRELLQR 501
            .    |.|:.:...|   :|.:|| ||..:.....|.:.                    :.:..:
Worm   375 RKPIFWQEVFDNNIP---DPNAVIHIWKGNTHEEIYEQV--------------------KNITSQ 416

  Fly   502 GYRLIVSTKNAWYLDHGFWGSTSYYNWRTVYSSGMPVG---------------RSKDQVLGGEVC 551
            .:.:|||.  .|||::..:|:    :||.......|..               ..|:.|.||...
Worm   417 NFPVIVSA--CWYLNYIKYGA----DWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAA 475

  Fly   552 MWSEYVDQNSLESRIWPRAGAAAERMWSNPKSS--ALLAQRRFYRYRERLLARG 603
            :|.|.||..::|:|:||||.|||||:||..:.:  |..|..|.:..|.||::||
Worm   476 IWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRG 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hexo2	NP_525081.1	Glycohydro_20b2	93..212	CDD:291511	32/149 (21%)
Hexo2	NP_525081.1	GH20_HexA_HexB-like	235..603	CDD:119332	117/397 (29%)
hex-1	NP_508409.1	Glyco_hydro_20b	<99..147	CDD:296005	20/56 (36%)
hex-1	NP_508409.1	GH20_HexA_HexB-like	170..529	CDD:119332	117/397 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159174
Domainoid	1	1.000	184	1.000	Domainoid score	I2031
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I2331
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	1	1.000	-	-		FOG0001678
OrthoInspector	1	1.000	-	-		otm14499
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.940