DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32523 and MASP1

DIOPT Version :9

Sequence 1:	NP_728401.1	Gene:	CG32523 / 318071	FlyBaseID:	FBgn0052523	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	285	Identity:	74/285 - (25%)
Similarity:	127/285 - (44%)	Gaps:	56/285 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NQSESAIEPRIVGGIKAKQGQFPHQISL------RLRGEHYCG-GVIISATHVITAGHCV---KH 81
            ::|..::..||:||..|:.|.||.|..:      |:..:.:.| |.::||:.::||.|.:   :.
Human   447 SRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRR 511

  Fly    82 GNDVVPADLWSIQAGSLLL-------SSDGVRIPVAEVIMHPNYATGGHN-DLAVLRLQSPLTFD 138
            ...|:|.   |.:..::.|       .|..|....|.|::||::....:| |:|:::||.|:...
Human   512 DTTVIPV---SKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLG 573

  Fly   139 ANIAAIQLATEDP----PNCVAVDISGWG---------NIAEKG--PLSDSLLFVQVTSISRGAC 188
            .::..:.|...:|    |:.:.: ::|||         .|...|  .|||.|.:|::..:....|
Human   574 PHVMPVCLPRLEPEGPAPHMLGL-VAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAEC 637

  Fly   189 RWMFYSR-----LPETMICL-LHSKNSGACYGDSGG------PATYGGKVVGLASLLLGGG---C 238
            :..:.||     :.|.|.|. .:......|.|||||      ..:....|.||.|   .||   |
Human   638 KTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVS---WGGPEEC 699

  Fly   239 GRAAPDG-YLRISKVRAWIAEKAGL 262
            |.....| |.::|....|:.|:.||
Human   700 GSKQVYGVYTKVSNYVDWVWEQMGL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32523	NP_728401.1	Tryp_SPc	36..256	CDD:214473	69/268 (26%)
CG32523	NP_728401.1	Tryp_SPc	37..219	CDD:238113	57/226 (25%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056
		Tryp_SPc	456..718	CDD:214473	69/268 (26%)
		Tryp_SPc	457..718	CDD:238113	68/267 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910