DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32523 and TMPRSS11A

DIOPT Version :9

Sequence 1:	NP_728401.1	Gene:	CG32523 / 318071	FlyBaseID:	FBgn0052523	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_872412.3	Gene:	TMPRSS11A / 339967	HGNCID:	27954	Length:	421	Species:	Homo sapiens

Alignment Length:	244	Identity:	73/244 - (29%)
Similarity:	116/244 - (47%)	Gaps:	28/244 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RIVGGIKAKQGQFPHQISLRLRGEHYCGGVIISATHVITAGHCV-KHGNDVVPADLWSIQAGSLL 99
            ||..|:.|.:..:|.|.||:....|.||..:||.|.::||.||. |:.|    ...|::..|:.:
Human   189 RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKN----PHQWTVSFGTKI 249

  Fly   100 ---LSSDGVRIPVAEVIMHPNYATGGHN-DLAVLRLQSPLTFDANIAAI---QLATEDPPNCVAV 157
               |....||    ..|:|..|.:.... |:||:::.|.:||..:|..|   :.:....|| :.|
Human   250 NPPLMKRNVR----RFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASFQPN-LTV 309

  Fly   158 DISGWGNIAEKGPLSDSLLFVQVTSISRGACR--WMFYSRLPETMICLLHSKN-SGACYGDSGGP 219
            .|:|:|.:...|...:.|...:|..||...|:  .::.:.:...|.|..:.:. ..||.||||||
Human   310 HITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGP 374

  Fly   220 -ATYGGK----VVGLASLLLGGGCG-RAAPDGYLRISKVRAWIAEKAGL 262
             .|...|    ::|:.|  .|..|| :..|..|.:::..|.|||.|.|:
Human   375 LVTRDLKDTWYLIGIVS--WGDNCGQKDKPGVYTQVTYYRNWIASKTGI 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32523	NP_728401.1	Tryp_SPc	36..256	CDD:214473	68/236 (29%)
CG32523	NP_728401.1	Tryp_SPc	37..219	CDD:238113	55/192 (29%)
TMPRSS11A	NP_872412.3	SEA	49..147	CDD:279699
		Tryp_SPc	189..415	CDD:214473	68/236 (29%)
		Tryp_SPc	190..418	CDD:238113	70/238 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910