DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32523 and PRSS53

DIOPT Version :9

Sequence 1:	NP_728401.1	Gene:	CG32523 / 318071	FlyBaseID:	FBgn0052523	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	332	Identity:	78/332 - (23%)
Similarity:	118/332 - (35%)	Gaps:	129/332 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLLCGVQVIL-GQDVAQNQSESAIEPRIVGGIKAKQ-----GQFPHQISLRLRGEHYCGGVIIS 68
            :||:.|..|:: |...||.    |...|..|..|.::     |::|.|.|:|.:|.|.|.|.:::
Human     8 VLLIAGATVLMEGLQAAQR----ACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAHICSGSLVA 68

  Fly    69 ATHVITAGHCVKHGNDVVPADLWSIQAGSLL---LSSDGVRIPVAEVIM---HPNYATGGHNDLA 127
            .|.|:||.||.:.. .....:.||:..|||.   ||.....:.||.:.:   :.:|:.|  :|||
Human    69 DTWVLTAAHCFEKA-AATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQG--SDLA 130

  Fly   128 VLRLQSPLT--------------FDANIAA-----------------------IQLATEDPPNC- 154
            :|:|..|.|              |.|:..|                       :...|...|||
Human   131 LLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCP 195

  Fly   155 --------------VAVDISGWGNIAEKGPLSDSLLFVQVTSISRGACRWMFYSRLPETMICLLH 205
                          .|..:|         |...:|..:::..|||..|. ..|::|.:.     |
Human   196 GFQSPLLPRSQTLAPAPSLS---------PAPGTLRNLRLRLISRPTCN-CIYNQLHQR-----H 245

  Fly   206 SKN---------------SGACYGDSGGPATYGGKVVGLASLLLGGGCGRAAPDGYLRISKVRAW 255
            ..|               .|.|.||||||..                |  ..|||:        |
Human   246 LSNPARPGMLCGGPQPGVQGPCQGDSGGPVL----------------C--LEPDGH--------W 284

  Fly   256 IAEKAGL 262
            :  :||:
Human   285 V--QAGI 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32523	NP_728401.1	Tryp_SPc	36..256	CDD:214473	67/297 (23%)
CG32523	NP_728401.1	Tryp_SPc	37..219	CDD:238113	60/259 (23%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	67/294 (23%)
		Tryp_SPc	43..314	CDD:214473	67/293 (23%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010