DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34120 and Abcg1

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_445954.2	Gene:	Abcg1 / 85264	RGDID:	620294	Length:	666	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	156/765 - (20%)
Similarity:	268/765 - (35%)	Gaps:	253/765 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   837 KKTDNYSFVKVSR-SQLDGKLGASLVNVS--------------KLYGSKCAVSNLSLDFARNQVS 886
            ||.|| :|.:..| |.|..:   :.||:.              :..|.|..:..:|..|...::.
  Rat    54 KKVDN-NFTEAQRFSSLPRR---AAVNIEFKDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELV 114

  Fly   887 CLLGRNGAGKSTLIKLLTGQIRQS--SGKVLLAGEHQVGVCW--------QDNILIPTLTAREHL 941
            .::|.:|||||||:.:|.| .|::  .|.||:.|..:...|:        ||::|:|.||.:|.:
  Rat   115 AIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGMPRDLRCFRKVSCYIMQDDMLLPHLTVQEAM 178

  Fly   942 QLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVI 1006
            .:.|.:|:.....|.    |..|.:.|.:|......:..:..||||.|:||.:|:..:.:|.|:.
  Rat   179 MVSAHLKLQEKDEGR----REMVKEILTALGLLPCANTRTGSLSGGQRKRLAIALELVNNPPVMF 239

  Fly  1007 LDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKY--LSDSLVIMRNGRIIAQHSRDSL 1069
            .|||.:|:|:.:...:..|::.|.||...|..|.....||.  |.|.|.::..|:.:   .|..:
  Rat   240 FDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQPSAKLFELFDQLYVLSQGQCV---YRGKV 301

  Fly  1070 QRLCTSNYSIRLRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTINASYAEHLTPGAVEF 1134
            ..|......:.|.|.                     |:...||:
  Rat   302 SNLVPYLRDLGLNCP---------------------TYHNPADF--------------------- 324

  Fly  1135 LELLQSQVTAGSISD-----VELTTSSSLEQEFE-QLNRNGEDAGP---RRPASDRSGVVAGPAM 1190
                ..:|.:|...|     |........:.::: :|..:| |..|   .|||.:.|..:.|...
  Rat   325 ----VMEVASGEYGDQNSRLVRAVREGMCDSDYKRELGGDG-DVNPFLWHRPAEEDSASMEGCHS 384

  Fly  1191 ITDEPPTAC-KQFRLLMGKRLRHLSRNYRL----------------LLYV--------LLLPALF 1230
            .:    .:| .||.:|..:....:.|:..|                |||:        :|..:.|
  Rat   385 FS----ASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGF 445

  Fly  1231 ELCAMWFVSYRLEDDFDTVL--PLSRSLYPQTAQFLSHERATSFSEKLYPQLRTSCDHLGECRVF 1293
            ...:|.|:.:...  ..|||  ||..|::                      ||   :|
  Rat   446 LFFSMLFLMFAAL--MPTVLTFPLEMSVF----------------------LR---EH------- 476

  Fly  1294 NTSQQSYDWVLNSWGEYSERRYGGYGLNGSGATVWYN---NKGYHSMMAWLNDLNSELLRTTMND 1355
                      ||.|  ||.:   .|.|..:.|.|.:.   ...|.|::.|:....|:.:|..:
  Rat   477 ----------LNYW--YSLK---AYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVL-- 524

  Fly  1356 SESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQR 1420
                           ||.|           |:|..::..:.||::.:.|..|
  Rat   525 ---------------FAAL-----------GTMTSLVAQSLGLLIGAASTSL------------- 550

  Fly  1421 LCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFG-------MPVFVDRQQLV-----GIIGLS 1473
                ...|:             :|.:..:.|:|..|       :|.::.....:     |..|:.
  Rat   551 ----QVATF-------------VGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVI 598

  Fly  1474 LAFSFACVPSVH--VAEKIFSDSSIAI---VSIFCANLIVPLVTMGIILI 1518
            |:........:|  :||......|.||   :.:..|.|.:..:.:||..|
  Rat   599 LSIYGLDREDLHCDIAETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230	64/239 (27%)
		drrA	865..1162	CDD:130256	72/313 (23%)
		ABC2_membrane_3	1230..1601	CDD:289468	55/311 (18%)
		Mem_trans	1436..>1552	CDD:304621	19/100 (19%)
		ABC_subfamily_A	1651..1857	CDD:213230
		drrA	1666..1945	CDD:130256
Abcg1	NP_445954.2	3a01204	60..666	CDD:273361	152/758 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000