DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and ABCA8

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_190363.3	Gene:	ABCA8 / 823933	AraportID:	AT3G47790	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	751	Identity:	180/751 - (23%)
Similarity:	317/751 - (42%)	Gaps:	193/751 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1308 GEYSERRYGGYGLNGSGATVWYN----NKGYHSMMAWLN-----DLNSELLRTTMNDSESSIL-- 1361
            |.:..:...|..||   .:||||    |......||.:.     :|.|......:..||:.||
plant   238 GAFDFQNTNGNNLN---VSVWYNSTYKNDTVVRPMALIRVPRLVNLASNAYLEFLKGSETKILFE 299

  Fly  1362 ---TLNEP-WKLGFAELSTSSILRQAGDGSMVF--ILLIAFGLVVASGSVYLVNERVNGEKLQQR 1420
               .:.:| .||   .|..:|::     |.:.|  ::|:.|.:::.:    ||.|:....::..:
plant   300 YVKEMPKPETKL---SLDIASLI-----GPLFFTWVILLLFPVILTT----LVYEKQQRLRIMMK 352

  Fly  1421 LCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGI-------IGLSLAFSF 1478
            :.|:..|.||:|:..:..|:.:| .::|..:   ||        .|:|:       ..:.|.|.|
plant   353 MHGLGDVPYWIVSYTYFLLISIL-YMLCFAI---FG--------SLIGLNFFRLNDYSIQLVFFF 405

  Fly  1479 AC----VPSVHVAEKIFSD----SSIAIVSIFCANLI----------VPLVTMGIILIL------ 1519
            .|    :....:|..:|||    :.||.:.:|...|:          .||...|.|:.:
plant   406 ICINLQISVAFLASAMFSDVKTATVIAYIYVFGTGLLGIFLFQFFLEDPLFPRGWIIAMELYPGF 470

  Fly  1520 -------------------GVVGDGPAWDDWRHALNQAFLIFPIH---ALGDGFLELCKNYMVAL 1562
                               |:  ||..|.|:.:.:.:...|..|.   .||..:      |:..:
plant   471 SLYRGLYELSQSAFAGDYRGI--DGMKWRDFGNGMKEVTCIMLIEWLLLLGLAY------YIDQI 527

  Fly  1563 VFRRYDIDSYKHPL-----ASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERLLDCTY 1622
            ::.|      ||||     ::....:||:       ...|..|::|          :|:...|..
plant   528 IYSR------KHPLFFLLQSTSKKKQHFS-------DNKISKVVVE----------MEKPDVCRE 569

  Fly  1623 RRELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAY--RRGH---YAVRNVNFSVQRGECFGL 1682
            |.:::          |.:.||..|:  ||...||...|  :.|:   .|||.::.::.:|||||:
plant   570 REKVE----------QCLLKSTRDS--AVLCNNLKKVYSGKDGNPQKLAVRGLSLALPQGECFGM 622

  Fly  1683 LGKNGAGKSTIFKLLTGQLQP--------------DVGQIYFEQPGISYCPQSNPLDPLLTTTEC 1733
            ||.|||||::...::||.::|              |:.:||   ..|..|||.:.|...|:..|.
plant   623 LGPNGAGKTSFINMMTGIIKPSSGTAFVQGLDILTDMDRIY---TTIGVCPQHDLLWEKLSGREH 684

  Fly  1734 IRFYGRLRGIRD--LDQFLDRVLDTYEL--RPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMD 1794
            :.|||||:.::.  |.|.::..|.:..|  ....|.||...|||.:|:|:||::..|....|.||
plant   685 LLFYGRLKNLKGSVLTQAVEESLRSVNLFHGGIGDKQVSKYSGGMKRRLSVAISLIGSPKVVYMD 749

  Fly  1795 EPTSDMDPVTRDMVYATIEQLLLARR--AVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLK 1857
            ||::.:||.:|..::..:::   |:|  |::||:||:.|.|.||.|:.:...|.:....:|:.||
plant   750 EPSTGLDPASRKSLWDVVKR---AKRKGAIILTTHSMEEAEILCDRIGIFVDGSLQCIGNPKELK 811

  Fly  1858 SEHGGYYAVTCFCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAP----LLS 1918
            |.:||.|.:|.......:..:.:.::.....|:.:...|.:.:|           :.|    .:.
plant   812 SRYGGSYVLTVTTSEEHEKEVEQLVHNISTNAKKIYRTAGTQKF-----------ELPKQEVKIG 865

  Fly  1919 ELFAIL--CDVCVNVARFSLSRCRFETVFERILDSS 1952
            |:|..|  ......|..:.|:....|.||.::..:|
plant   866 EVFKALEKAKTMFPVVAWGLADTTLEDVFIKVAQTS 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230
		drrA	865..1162	CDD:130256
		ABC2_membrane_3	1230..1601	CDD:289468	75/367 (20%)
		Mem_trans	1436..>1552	CDD:304621	32/168 (19%)
		ABC_subfamily_A	1651..1857	CDD:213230	75/230 (33%)
		drrA	1666..1945	CDD:130256	87/304 (29%)
ABCA8	NP_190363.3	ABC2_membrane_3	<247..488	CDD:289468	56/267 (21%)
		BI-1-like	367..>451	CDD:294323	19/95 (20%)
		CcmA	585..897	CDD:224054	95/328 (29%)
		ABC_subfamily_A	590..811	CDD:213230	74/226 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710