DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and ABCA7

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_190362.2	Gene:	ABCA7 / 823932	AraportID:	AT3G47780	Length:	935	Species:	Arabidopsis thaliana

Alignment Length:	773	Identity:	174/773 - (22%)
Similarity:	318/773 - (41%)	Gaps:	188/773 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1294 NTSQQSYDWVL------NSWGEYSERRYGGYGL-----NGSGATVWYNNKGYHSMMAWLNDLNSE 1347
            |||::..|.:.      |..|:.:|.. ..|.|     |.....:|||:       .:.:|..:.
plant   234 NTSKEVNDKIFKGYKKGNPEGKINEIA-AAYDLLNTDRNNFNVHIWYNS-------TYKDDAGNR 290

  Fly  1348 LL------RTTMNDSESSILTLNEPWKLGFAE-------------LSTSSILRQAGDGSMVF--I 1391
            |:      |:....|.:.:..|..|......|             |..:|::     |.:.|  :
plant   291 LIKLIRVPRSVNLVSNAYLQFLQGPGTRMLFEYVKEMPKPETSLRLDIASLI-----GPLFFTWV 350

  Fly  1392 LLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFG 1456
            :|:.|.::::|    ||.|:....::..::.|:....||:::..:...:.|| .::||::   ||
plant   351 ILLLFPVILSS----LVYEKQQHLRIIMKMHGLGDGPYWMISYAYFLTISVL-YVICLMI---FG 407

  Fly  1457 MPVFVDRQQLVG----------IIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLV 1511
            ..:.:...:|..          .:.|.:|.:| .|.||.  .|:.:.:..:.:.:|.:.|
plant   408 SAIGLKFFRLNSYSIQFVFYFLYLNLQIALAF-LVSSVF--SKVKTSTVASYIYVFGSGL----- 464

  Fly  1512 TMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPL 1576
             :|:.|:..::.|......|...:.    ::|..:|..|..||.:     ..||
plant   465 -LGLFLLNFLIEDSSFPRGWIIVME----LYPGFSLYRGLYELAQ-----FAFR----------- 508

  Fly  1577 ASDLLGRHFTALLLVGVAAL---IINVLIEWHLLRRLWQRVERLLDCTYRRELDKLGQLKLVNIQ 1638
             .:|.|.........|.:|:   ...:::||.|         .|:...|..::...|:..|..:|
plant   509 -GNLRGEDGMKWKDFGDSAMDDVFYIIVVEWFL---------ALIAAYYIDKISSSGRNPLFFLQ 563

  Fly  1639 SIFKS----------------CVD------TGEAVRAENLWLAYRRGH----------------- 1664
            :.||.                .||      |.|:.:.|.|.|.....|
plant   564 NPFKKSPSLRRPSLQRQGSKVSVDMEKPDVTHESKKVERLMLESSTSHAIVCDNLKKVYPGRDGN 628

  Fly  1665 ---YAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQP--------------DVGQIYFEQ 1712
               .|||.::.:|..|||||:||.|||||::...::||.|:|              |:.::|
plant   629 PPKLAVRGLSLAVPSGECFGMLGPNGAGKTSFINMMTGLLKPTSGTALVQGLDICNDMDRVY--- 690

  Fly  1713 PGISYCPQSNPLDPLLTTTECIRFYGRLRGIR--DLDQFLDRVLDTYEL--RPYKDVQVRNLSGG 1773
            ..:..|||.:.|...||..|.:.|||||:.::  ||:|.::..|.:..|  ....|......|||
plant   691 TSMGVCPQHDLLWETLTGREHLLFYGRLKNLKGADLNQAVEESLKSVNLFHGGVADKPAGKYSGG 755

  Fly  1774 NRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARR--AVVLTSHSVSEIEHLC 1836
            .:|:|:||::..|....|.||||::.:||.:|..::..|::   |::  |::||:||:.|.|.||
plant   756 MKRRLSVAISLIGNPKVVYMDEPSTGLDPASRKNLWTVIKR---AKQNTAIILTTHSMEEAEFLC 817

  Fly  1837 QRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQRLPGARDLQHYAHSLRF 1901
            .|:.:...|.:....:|:.||..:||.|..|.......:..:.:.:....|.|:.:.|.|.:.:|
plant   818 DRLGIFVDGGLQCIGNPKELKGRYGGSYVFTMTTSSEHEQNVEKLIKDVSPNAKKIYHIAGTQKF 882

  Fly  1902 LV---RVRSPGSLGDAPLLSELFAILCDVCVNVARFS--LSRCRFETVFERILDSSES 1954
            .:   .||          :||:|..:.....|...|:  |:....|.||.:::.:.::
plant   883 ELPKEEVR----------ISEVFQAVEKAKSNFTVFAWGLADTTLEDVFIKVVRNGQA 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230
		drrA	865..1162	CDD:130256
		ABC2_membrane_3	1230..1601	CDD:289468	64/351 (18%)
		Mem_trans	1436..>1552	CDD:304621	23/125 (18%)
		ABC_subfamily_A	1651..1857	CDD:213230	74/245 (30%)
		drrA	1666..1945	CDD:130256	90/303 (30%)
ABCA7	NP_190362.2	ABC2_membrane_3	<324..>458	CDD:289468	27/149 (18%)
		CcmA	612..926	CDD:224054	92/329 (28%)
		ABC_subfamily_A	617..838	CDD:213230	70/226 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710