DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and ABCA5

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_001326002.1	Gene:	ABCA5 / 823930	AraportID:	AT3G47760	Length:	936	Species:	Arabidopsis thaliana

Alignment Length:	782	Identity:	183/782 - (23%)
Similarity:	310/782 - (39%)	Gaps:	209/782 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1304 LNSWG----EYSERRYGGY---------------------GLNGSGATVWYNN--KG-------- 1333
            ||.|.    |.|...:.||                     .:|....|:|||:  ||
plant   230 LNLWRNNSIEISNEIFKGYRQGNLEEIINEVAAAYDLMDTDINNFNVTIWYNSTYKGDLRDRRVK 294

  Fly  1334 YHSMMAWLNDLNSELLRTTMNDSESSILTL--NEPWKLGFAELSTSSILRQAGDGSMVFILLIAF 1396
            |..:...:|.:::..|..........:...  ..|.:.....|..:|::   |.....:::|:.|
plant   295 YVRVPRSVNLVSNAYLEFLQGSGTKMLFDFVKEMPKQETRLRLEMASLI---GPIFFTWVILLLF 356

  Fly  1397 GLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFV 1461
            .:::.|    ||.|:....::..::.|:....||::...: :|.:.:..|:||::   ||
plant   357 PVMLTS----LVYEKQQHLRIIMKMHGLGDGPYWMITYAY-FLAISIVYIICLMI---FG----- 408

  Fly  1462 DRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIF-CANLIVPLV-----------TMG 1514
                  ..|||..   |.           |:|.||..:..| |.||.:.:.           |..
plant   409 ------SAIGLKF---FR-----------FNDYSIQFIFYFLCINLQISIAFLVSSAFSKIETAS 453

  Fly  1515 IILILGVVGDGPAWDDWRHALNQAFLI--------FP-----IHALGDGFLELCKNYMVALVFRR 1566
            :...|.|.|.|         |..|||.        ||     |..|..||    ..|.....|.:
plant   454 VAAYLYVFGSG---------LLGAFLFQFLLEGLSFPRSWIYIMELYPGF----SLYRGLYEFSQ 505

  Fly  1567 YDIDSYKHPL--ASDLLGRHFTALLLVGVAALIINVLIEWHL---------------------LR 1608
            |   ::|..|  :..:..:.|....:..:..:||   :||.:                     |:
plant   506 Y---AFKRNLNGSGGMKWKDFNDSAMEEIFYIII---VEWFVALIAAYYTDKISSSGIDPFFFLK 564

  Fly  1609 R------------LWQRVERL------LDCTYRRELDKLGQLKLVNIQSIFKSCVDTGEAVRAEN 1655
            .            |.::|..:      ||..:.|.  |:.||.|.         ..||.|:..:|
plant   565 NQNPFKKSPSPYGLQRQVSAIAIEMEKLDVAHERV--KVEQLMLE---------TSTGHAIVCDN 618

  Fly  1656 LWLAY--RRGH---YAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFE---- 1711
            |...|  |.|:   .|||.::.:|..|||||:||.|||||::...::||.::|..|..:..
plant   619 LKKVYPCRDGNPQKMAVRGLSLAVPSGECFGMLGPNGAGKTSFINMMTGLMKPTSGAAFVHGLDI 683

  Fly  1712 -------QPGISYCPQSNPLDPLLTTTECIRFYGRLRGIR--DLDQFLDRVLDTYEL--RPYKDV 1765
                   ...|..|||.:.|...||..|.:.|||||:.::  ||||.::..|.:..|  ....|.
plant   684 CKDMDIVYTSIGVCPQHDLLWETLTGREHLLFYGRLKNLKGSDLDQAVEESLKSVNLFRGGVADK 748

  Fly  1766 QVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARR--AVVLTSHS 1828
            .....|||.:|:|:||::..|....|.||||::.:||.:|..::..|::   |:.  |::||:||
plant   749 PAGKYSGGMKRRLSVAISLIGSPKVVYMDEPSTGLDPASRRSLWTAIKR---AKNHTAIILTTHS 810

  Fly  1829 VSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQRLPGARDLQ 1893
            :.|.|.||.|:.:...|::....:|:.||:.:||.|.:|.......:..:...:....|.|:.:.
plant   811 MEEAEFLCDRLGIFVDGRLQCVGNPKELKARYGGSYVLTMTTPSEHEKDVEMLVQDVSPNAKKIY 875

  Fly  1894 HYAHSLRFLV---RVRSPGSLGDAPLLSELFAILCDVCVN--VARFSLSRCRFETVFERILDSSE 1953
            |.|.:.:|.:   .||          :||:|..:.....|  |..:.|:....|.||.::..:::
plant   876 HIAGTQKFEIPKEEVR----------ISEVFQAVEKAKDNFRVFAWGLADTTLEDVFIKVARTAQ 930

  Fly  1954 SN 1955
            ::
plant   931 AS 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230
		drrA	865..1162	CDD:130256
		ABC2_membrane_3	1230..1601	CDD:289468	71/360 (20%)
		Mem_trans	1436..>1552	CDD:304621	32/140 (23%)
		ABC_subfamily_A	1651..1857	CDD:213230	75/227 (33%)
		drrA	1666..1945	CDD:130256	90/300 (30%)
ABCA5	NP_001326002.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720