DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34120 and Abca2

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:XP_006233707.2 Gene:Abca2 / 79248 RGDID:620238 Length:2435 Species:Rattus norvegicus


Alignment Length:2236 Identity:494/2236 - (22%)
Similarity:797/2236 - (35%) Gaps:700/2236 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 FVKLGV----LLCGHPFPNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTDWRPTK 241
            ||:|..    :|||:           |..:|.|...:.|.:.:......:|              
  Rat   406 FVQLWAGLQPILCGN-----------NRTIEPEALRRGNMSSLGFTSKEQR-------------- 445

  Fly   242 YCKRLYRDVTSTNQGKLT-WNTIKPIIQGRILYTPANAMTESVVKFSN----------------- 288
                        |.|.|. ..|..|    :|||.||.:..:.|:..:|                 
  Rat   446 ------------NLGLLVHLMTSNP----KILYAPAGSEADHVILKANETFAFVGNVTHYAQVWL 494

  Fly   289 ------ASFEELDRLKQ----LSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDI 343
                  .||.|..||:|    |.:..|.:  :||..|         :.|:...|..:|..|.|.:
  Rat   495 NISAEIRSFLEQGRLQQHLHWLQQYVADL--RLHPEA---------MNLSLDELPPALRLDYFSL 548

  Fly   344 GEIERVFEYIRTNQLIYDILTTVA----DLMDCVSADRFEAVESVEELHKRAYELNQ----NKLF 400
            .....:.:.:       |.:...|    ..|..||.|.|:.....|.:..  |.|||    |...
  Rat   549 PNGTALLQQL-------DTIDNAACGWIQFMSKVSVDIFKGFPDEESIVN--YTLNQAYQDNVTV 604

  Fly   401 LAAL---NLEDVGL-KQASYRLHMDTDNTQPTFENRNRFWFPGPADSMVIDLKYHRGFVQLKQMV 461
            .|::   ..:|..| ....|::..::..|:.|.|.|..:|.|||.........|  |||.::.|:
  Rat   605 FASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY--GFVWIQDMI 667

  Fly   462 DLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVS 526
            :..||.:                                                          
  Rat   668 ERAIINT---------------------------------------------------------- 674

  Fly   527 ASASDHEATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGG 591
                                                     ....||::...             
  Rat   675 -----------------------------------------FVGHDVVEPGN------------- 685

  Fly   592 SGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQ-VAYLLGLVVFVALSVRERIWM 655
                             |.:.||||.:..|.|   |::.:.:. :..::..|..||::::..:..
  Rat   686 -----------------YVQMFPYPCYTRDDF---LFVIEHMMPLCMVISWVYSVAMTIQHIVAE 730

  Fly   656 RESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTN----WFFMMFYCL 716
            :|.|...:|::|||......|||.:..|::|.:....::.:|..|.:|.:::    |.|:..|.:
  Rat   731 KEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVLIIWLFLAVYAV 795

  Fly   717 SFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDA----KLSVFESFLVDLSFT 777
            :    .|.||::.:..::.|.:.:....:::|:|..|::.|.:.:.    |::.||..:..|..|
  Rat   796 A----TIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMST 856

  Fly   778 TAFAKGWGELIRMELQQEGLTVRHLIQVGPARSE---CAMALLMFLLDLLLYAVI---------- 829
            |||..|.......|:...|:. .|.....|...:   ..:|:.|.::|.::|.|:          
  Rat   857 TAFGLGSKYFALYEVAGVGIQ-WHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIEAVHPG 920

  Fly   830 --GLAYQRY-----------KKTDNYSF-------------------------VKVSRSQLDGKL 856
              ||....|           .:|:.:.:                         .:.:|...:...
  Rat   921 MYGLPRPWYFPLQKSYWLGSGRTETWEWSWPWAHAPRLSVMEEDQACAMESRHFEETRGMEEEPT 985

  Fly   857 GASLV----NVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVL 915
            ...||    .::|:|  ..|.|::.|||:...|||...||.|||||:|.:.:|||....:||...
  Rat   986 HLPLVVCVDKLTKVYKNDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1050

  Fly   916 LAGEHQV-----------GVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQ 969
            :.| |.:           |:|.|.|:|...||..|||..|:::|     |...||||.|:.:.::
  Rat  1051 IYG-HDIRTEMDEIRKNLGMCPQHNVLFDQLTVEEHLWFYSRLK-----SMAQEEIRKEMDKMIE 1109

  Fly   970 SLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRA 1034
            .|............||||.:|:|.|||||:.....:|||||..|||..||:.||.||.:.:.||.
  Rat  1110 DLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRT 1174

  Fly  1035 VIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQL 1099
            ::.:||.||||..|.|.:.|:.:|::          :.|.|...::....|...:|.|.:.|:  
  Rat  1175 ILLSTHHMDEADLLGDRIAIISHGKL----------KCCGSPLFLKGAYGDGYRLTLVKRPAE-- 1227

  Fly  1100 LPQTQVTHSGAADYP-----------------------HSLTIN-----ASY---AEHLTPGAVE 1133
             |.|. ...|.|..|                       .||.::     .||   :|.:..||.|
  Rat  1228 -PGTS-QEPGMASSPSGRPQLSNCSEMQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFE 1290

  Fly  1134 FL-ELLQSQVTAGSISDVEL--TT-----------SSSLEQEFEQLNRNGEDAGP---------- 1174
            .| :.|:..:.|..:|...|  ||           ..|||.....:..:.:||.|          
  Rat  1291 RLFQQLEHSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDALPGAEGLTAVES 1355

  Fly  1175 ------------RRPASDRSGVVAGPAM------ITD-------------EPPTA---------- 1198
                        :..||.:|....|.|.      .||             :|.:.          
  Rat  1356 QAGNLARCSELAQSQASLQSASSVGSARGDEGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEAL 1420

  Fly  1199 ----------------CKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMW----------- 1236
                            .:||..|:.||.....||.:.|...:||||.|...||.           
  Rat  1421 ARVGQGSRKLEGWWLKMRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDL 1485

  Fly  1237 -------------------FVSY----------RLEDD--------------------------- 1245
                               |:.|          ||..|                           
  Rat  1486 PPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPAN 1550

  Fly  1246 ---------------------FDTV--------LPLS--------------------------RS 1255
                                 ||::        ||||                          .:
  Rat  1551 GSLGPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPLSPDEDSLLAWNT 1615

  Fly  1256 LYPQTAQFLSHERATSFSEKLYPQLRTSCD--------------HLGECRVFN-------TSQQS 1299
            ..|.||...:...|.|....::..:|.:|.              |..:.||..       |....
  Rat  1616 SLPPTAGPETWTWAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNV 1680

  Fly  1300 YDWVLNSWGEYSERRYGGYGLNG-----------------------SGATVWYNNKGYHSMMAWL 1341
            .:::|.:...:...|||......                       ..|.|.|||||||||..:|
  Rat  1681 SEYLLFTSDRFRLHRYGAITFGNIQKSIPAPIGTRTPLMVRKIAVRRVAQVLYNNKGYHSMPTYL 1745

  Fly  1342 NDLNSELLRTTM-----NDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVA 1401
            |.||:.:||..:     |.:...|...|.|.....|.||...:| |..|..:...:::|...|.|
  Rat  1746 NSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLL-QGTDVVIAIFIIVAMSFVPA 1809

  Fly  1402 SGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQL 1466
            |..|:||.|:....|..|.:.|.:.|.|||...|||.|..::....|::::.:|.:|.:......
  Rat  1810 SFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNF 1874

  Fly  1467 VGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPL-VTMGIILI--------LGVV 1522
            ..::.|.|.:.::..|.::.|...|...|.|.|.:...||.:.: .|:...|:        |.||
  Rat  1875 PAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVV 1939

  Fly  1523 GDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRY-DIDSYKHPLASDLLGRHFT 1586
            ..         .|...|||||.:.||.|.:|:..|..:...:.:. ..|..|.|...|::.|...
  Rat  1940 NS---------YLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLV 1995

  Fly  1587 ALLLVGVAALIINVLIEWHLLRRLWQR-------VERLLDCTYRRELDKLGQLKLVNIQSIFKSC 1644
            |:.:.|.....:.::.:::.||:. ||       ||..:|....|             |.:.:..
  Rat  1996 AMTVEGFVGFFLTIMCQYNFLRQP-QRLPVSTKPVEDDVDVASER-------------QRVLRGD 2046

  Fly  1645 VDTGEAVRAENLWLAYRRGH----YAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDV 1705
            .| .:.|:.|||...|:...    .||..:...|:.||||||||.|||||::.||:|||......
  Rat  2047 AD-NDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG 2110

  Fly  1706 GQIYFE-----------QPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTY 1757
            |:.:..           |..:.||||.:.|...||..|.::.|.|||||  :|..|.:...|:..
  Rat  2111 GEAFVNGHSVLKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALEKL 2175

  Fly  1758 ELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAV 1822
            ||....|....:.||||:|||:.|:...|....:.:||||:.|||..|..::..|..|:...|:|
  Rat  2176 ELTKCADKPAGSYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSV 2240

  Fly  1823 VLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQA-ILSRSLNQRL 1886
            ||||||:.|.|.:|.|:|::..|::....|.|.||:..|..|.:|.....:|.. .:.|..|:..
  Rat  2241 VLTSHSMEECEAVCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNVKDVVRFFNRNF 2305

  Fly  1887 PGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDV--CVNVARFSLSRCRFETVFERIL 1949
            |.|...:.:...:::.::       .:...|:::|:.:..|  .:.:..:|:|:...:.||....
  Rat  2306 PEAMLKERHHTKVQYQLK-------SEHISLAQVFSKMEHVVGVLGIEDYSVSQTTLDNVFVNFA 2363

  Fly  1950 DSSESNGSNGVHKDQQQQVAKNDLPS 1975
            .....|       .:||:...:.|||
  Rat  2364 KKQSDN-------VEQQEAEPSTLPS 2382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 31/143 (22%)
ABC_subfamily_A 859..1073 CDD:213230 83/230 (36%)
drrA 865..1162 CDD:130256 110/354 (31%)
ABC2_membrane_3 1230..1601 CDD:289468 111/551 (20%)
Mem_trans 1436..>1552 CDD:304621 30/124 (24%)
ABC_subfamily_A 1651..1857 CDD:213230 83/222 (37%)
drrA 1666..1945 CDD:130256 93/294 (32%)
Abca2XP_006233707.2 rim_protein 1..2369 CDD:130324 488/2214 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342252
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.650

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