Protein Alignment CG34120 and Abca6

DIOPT Version :9

• Sequence 1: NP_001285513.1
• Gene: CG34120 / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: NP_671751.2
• Gene: Abca6 / 76184
• MGIID: 1923434
• Length: 1624
• Species: Mus musculus
• Alignment Length: 1540
• Identity: 365/1540 - (23%)
• Similarity: 628/1540 - (40%)
• Gaps: 352/1540 - (22%)

  Fly   637 YLLGLVVFVALSV-RERIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSG 700
            |....:.|.:.:| :||...:|     :|:.|||:..:..::|.|:....:.:|...|:.::.|.
Mouse   230 YFSSFIYFASSNVTKERKQCKE-----VMKVMGLQDSAFWLSWGLIYVGFIFIISIFIAIIITST 289

  Fly   701 GILGYTNW--FFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISL---CPFIIVL-- 758
            .|:..|.:  .|.:|:.  :||.||:..::.......|   .:.:.::.|.:|   |....||
Mouse   290 QIIMMTGFLVIFTLFFL--YGLSLIAVTFLMAVLLQKA---VLTNLIVLFFTLFWGCVGFTVLHK 349

  Fly   759 ----MFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSECAMALLMF 819
                ..:..||:|..|        ||..|..::|..:....|     ::...|:.....|..:.|
Mouse   350 ELPPSLEWVLSIFSPF--------AFTSGMAKVIFQDYNLNG-----VVFPDPSGESYVMIAVFF 401

  Fly   820 LL--DLLLYAVIGLAYQR---------------------YKKTDNYSFVKVSRSQLD-------- 853
            :|  |.|||.|:.|.:.:                     ::||.|.:  ||....||
Mouse   402 ILAFDSLLYLVLALYFDKILLYGAEHRSAPLFFLNPTSCFRKTANRN--KVIERDLDPELPSDEY 464

  Fly   854 ---------GKLGASLVNVSKLYGSKC----AVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTG 905
                     ||....:.|:.|.|..|.    |:..|.||...:|::.:||.:|||||:|:.:|:|
Mouse   465 FEPVDPEYQGKEAIRIRNIKKEYKGKSGKVKALKGLFLDIYESQITAILGHSGAGKSSLLNILSG 529

  Fly   906 QIRQSSGKVLLAGEH------------QVGVCWQDNILIPTLTAREHLQLYAQIK-IPPGGSGGV 957
            ....::|.|.:..::            .:|||.|.|:....||.:|:|.|:|:|| |.|
Mouse   530 LYVPTAGSVTVYNKNLSDMQDLKEIRKAIGVCPQHNVQFDALTVKENLTLFAKIKGILP------ 588

  Fly   958 EEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDI 1022
            :::..||.|.|..|:........:..||.|.:|:|...||.:..|.:::||||..|:|..:|:.|
Mouse   589 QDVEQEVQQILSELDMQNIRDDLAEHLSEGQKRKLTFGIATVGDPQILLLDEPTVGLDPFSRQRI 653

  Fly  1023 WQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRL---RCA 1084
            |..::..|....::|:|.|||||..|:|..|::.||.:....|...|:|.....|.:.|   ...
Mouse   654 WGFLKERRADHVILFSTQFMDEADILADRKVLIANGALKCTGSSVFLKRKWGLGYHLSLFMDETC 718

  Fly  1085 DATGVTFVI--------------QKAQQLLPQTQVTHSGAADYPHSLTINASYAEHLTPGAVEFL 1135
            |:..:|..|              :|...:||..:     .:::|...:....|:..
Mouse   719 DSERLTSFINHHIPYAKLKAKTKEKLVYILPLER-----TSEFPEFFSDLDKYSGQ--------- 769

  Fly  1136 ELLQSQVTAGSISDV--ELTTSSSLEQEFEQLNRNGEDAGPRRPASDRSGV----VAGPAM--IT 1192
            .|:..:|:..:::||  .|....|.:|:||:          |..|:|...:    ||.|::  :.
Mouse   770 GLMSYEVSMSTLNDVFLNLEGEPSTKQDFEK----------RETATDSESLNDMEVAYPSLSQVQ 824

  Fly  1193 DEPPT---------ACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDT 1248
            :...|         |..:.|:|..||.|.......|||.:.|||.:.|..|...:..:...:|.|
Mouse   825 ETVSTMSLWRMQVCAIARLRILKLKRERKAFLIILLLLGIALLPLVIEYVANALLEVKNNWEFKT 889

  Fly  1249 VLPLSRSLYPQTAQFLSHERATSFSEKLYPQ-LRTSCDHLGECRVFNTSQQSYDWVLNSWGEYS- 1311
                  .||     |||..:        .|| ||||      ..|.|.::.:.:..|.|....:
Mouse   890 ------DLY-----FLSPGQ--------LPQGLRTS------LLVINNTESNIEDFLQSLKHQNI 929

  Fly  1312 -------ERRYGGYGLNGSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILTLNEPWKL 1369
                   |.|.....|:.:||.:....:..:...|..|..........||...:.||.:
Mouse   930 VLEVDDFENRNATNSLSYNGAIIVSGRQKDYRFSAVCNTKRLHCFPILMNVISNGILHM------ 988

  Fly  1370 GFAELSTSSILRQAGDGSMVFILLIAFGL---------VVASGSVYLVNERVNGEK----LQQRL 1421
                |:.:..:|...|....||:|:..|:         |:.|.|.::....|:..|    .|..:
Mouse   989 ----LNHTQYIRIKEDIFSPFIVLVWTGIQETCLFILCVICSLSPHIAMSSVSDYKKKADSQLWI 1049

  Fly  1422 CGVSAVTYWLVALVWDYLVMVLGLIVC---------LVVILMFGMPVFVDRQQLVGIIGLSLAFS 1477
            .|:....||....|.| :.:..|:::.         |:.|.|....||       .:|.|:|..:
Mouse  1050 SGLYPSAYWCGQAVVD-ISLFSGMLLTSYFTSYTSKLLNIDMTSEIVF-------SVIVLALGCA 1106

  Fly  1478 FACVPSVHVAEKIFS--DSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFL 1540
            .:.|...:|...:|.  ..:..:.|| |..|:       |.:....|.:||        .|:|.:
Mouse  1107 ASLVFLTYVISFVFGKRKKNSTLWSI-CFLLV-------IAITFEKVANGP--------FNEALV 1155

  Fly  1541 I-----FPIHALGDGFLELCKNYMVALVFRRY----DIDSYKHPL-ASDLLGRHFTALLLVGVAA 1595
            |     .|..|| :|.|       |.|..|.|    :.:..||.| |.|||      |.|:....
Mouse  1156 ISATMLVPSFAL-NGLL-------VVLEMRAYQYYIEFEEIKHGLSAVDLL------LCLIPYIH 1206

  Fly  1596 LIINVLIEWHLLRRLWQRVERLLDCTYRRELDKLGQLKLVNIQSIF-----KSCVDTGEAVRAEN 1655
            .::.:.            |.|.|:..|.:.:.:...:..:..||:.     :..:|..|.|:||.
Mouse  1207 TLLFIF------------VLRCLELKYGKNVVRRDPIFRIAPQSLKAQPNPEEPIDEDENVQAER 1259

  Fly  1656 L--------------------------------WLAYRRGHYAVRNVNFSVQRGECFGLLGKNGA 1688
            |                                ..:.|..:.|||||:|.|.:||..||||.:||
Mouse  1260 LRTSDALSTPNLDEKPVIIASCLHKEYAGQKKHCCSRRTRNMAVRNVSFCVNKGEILGLLGPDGA 1324

  Fly  1689 GKSTIFKLLTGQLQPDVGQIYFE------------QPGISYCPQSNPLDPLLTTTECIRFYGRLR 1741
            |||:..:::.|..:|..||:..:            :....||||.|.|.|.||..|.:..|..::
Mouse  1325 GKSSSIRMIAGITKPTAGQVELKRLSSAVGHQGDSRAEFGYCPQENGLWPNLTVKEHLELYAAVK 1389

  Fly  1742 GIRDLDQF--LDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVT 1804
            |:|..|..  :.|:::..:|....:|||:||..|..|||...::..|.:|.:::|||::.:|...
Mouse  1390 GLRKEDAVVAISRLVNALKLHDQLNVQVQNLVAGATRKLCFVLSILGNSPVLILDEPSTGLDVSG 1454

  Fly  1805 RDMVYATIEQLLL-ARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTC 1868
            :..|:..|:.::. ..:.|:|::|.::|.|.||.|.|::.:|::......|.||.:.|..|.:..
Mouse  1455 KHQVWQAIQAVVKDNEKGVLLSTHDLAEAEALCDRAAIMVSGRLRCIGPIQHLKRKFGQDYVLEL 1519

  Fly  1869 -FCGPAQQAILSRSLNQRLP-GARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDV--CV 1929
             ....:|:.::.|.:.:..| .||..:.::     |:..:.|  :.|...||:.|..|..|  ..
Mouse  1520 RVKDVSQEPLVHREILKLFPQAARQDRCFS-----LLTYKLP--VTDVHPLSQAFHKLEAVKHGF 1577

  Fly  1930 NVARFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVAKNDLP 1974
            ::..:|||:|..:.|   ||:.|:......|:::....:.:..||
Mouse  1578 DLEDYSLSQCTLDRV---ILELSKEQELGTVYEEADMTLGRKLLP 1619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	29/134 (22%)
		ABC_subfamily_A	859..1073	CDD:213230	74/230 (32%)
		drrA	865..1162	CDD:130256	90/332 (27%)
		ABC2_membrane_3	1230..1601	CDD:289468	89/413 (22%)
		Mem_trans	1436..>1552	CDD:304621	28/131 (21%)
		ABC_subfamily_A	1651..1857	CDD:213230	71/252 (28%)
		drrA	1666..1945	CDD:130256	87/297 (29%)
Abca6	NP_671751.2	rim_protein	<169..1600	CDD:130324	362/1519 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740