DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and Abca14

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	XP_017167760.1	Gene:	Abca14 / 67928	MGIID:	2388708	Length:	1719	Species:	Mus musculus

Alignment Length:	1588	Identity:	379/1588 - (23%)
Similarity:	673/1588 - (42%)	Gaps:	333/1588 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 NMQFYTKQFPYPAFLNDVF-----------------KRGLYLAQGVQV------------AYLLG 640
            |...|.::||:|||::|.|                 :..|.:...:.:            ||:..
Mouse   232 NTTIYAERFPHPAFIHDSFLWTFIAMFPWTILFTFTQMALVIVGTIMLEKEKRLKLTYMYAYVPR 296

  Fly   641 LVVFVALSVRERIWMR--------ESRNSMLMRSMGLKAHSELVAWA-------LMSFLELCVIF 690
            :.:|.|.: |...|:.        |.....||  :||   |..:.|.       ||.|:.:|
Mouse   297 VCLFPAKN-RRGCWIPGMEVTDGCEHPEYQLM--VGL---SNAMLWVSYFITFLLMYFIIIC--- 352

  Fly   691 ALISGVLY----SGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISL 751
             |:.|:|:    ...:..:::..|:.||.:.|.:..:...::.:..||.|::....:..|.|::.
Mouse   353 -LLCGILFLKITHERVFQHSDPLFIAFYFMCFAVSSVLLGFLISTLFNKASLATSIAGFLHFLTF 416

  Fly   752 CPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQQEG---------------LTVRH 801
            .|::|:.....::|:.....:.|...||.|.|...:.::|::..|               ||:.|
Mouse   417 FPYLILYHKYDQISLSGKLALCLITNTALAFGTDLICKLEMKGHGAQWNNFATKVNADDDLTLAH 481

  Fly   802 LIQVGPARSECAMALLMFLLDLLLYAVIGLAYQR-------YKKTDNYSFVK--------VSR-- 849
            :|.             |||....||.::......       ..|..|:...|        :||
Mouse   482 IIG-------------MFLFSAFLYGLVAWYLDAVFPGTYGVPKPWNFFLQKAYWFGEPALSREE 533

  Fly   850 SQLDGKLGASL-----------VNVSKLY-------GSKCAVSNLSLDFARNQVSCLLGRNGAGK 896
            ||:...|.:..           :.:..||       .:..||::|||:....|::.|||.|||||
Mouse   534 SQVSDLLSSDFMEPEPVGLVAGIRIQHLYKEFILKNSTLMAVNDLSLNLYEGQITVLLGHNGAGK 598

  Fly   897 STLIKLLTGQIRQSSGKVLLAG----------EHQVGVCWQDNILIPTLTAREHLQLYAQIK-IP 950
            :|.:.:|||....:.|||.::|          ...:|:|.||::|.|.||..|||..|..|| ||
Mouse   599 TTTLSILTGLYLPTRGKVYISGYDISSDMVQIRKSLGLCPQDDLLFPMLTVSEHLHFYCVIKGIP 663

  Fly   951 PGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVD 1015
                  ::....|..:.|.|....:..:..|..||||.:|:|.:.||.|....|||||||.:|:|
Mouse   664 ------LQNQSRETNRMLTSFGLLQQSNTMSKDLSGGMKRKLSIIIALIGDTKVVILDEPTSGMD 722

  Fly  1016 AKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIR 1080
            ..:|:..|.|::..::.|.::..||.||||..|.|.:.|:..|.:....|...|::|....|.:.
Mouse   723 PVSRRATWDLLQHYKKDRTILLTTHHMDEADVLGDRIAILVMGILKCCGSSLFLKKLYGVGYHLV 787

  Fly  1081 LRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTINASYAEHLTPGAVEFLELLQSQVTAG 1145
            :.....:....:.|..:..:|..::..:.||:....|.     .||....|..|.:|.:.|...|
Mouse   788 IVKTPDSNDEKIFQLIKNYIPTAKMETNVAAELSFILP-----KEHTHRFAELFTDLEEKQEELG 847

  Fly  1146 -------------------SISDVELTT---------SSSLEQEFEQLN--RNGEDAGPRRPASD 1180
                               ::.|::|.|         |.|..::.:.:|  ||.|..|..|...|
Mouse   848 ISGFGVSMTTMDEVFFKVSNLEDLKLNTEIAPSASIVSQSSNEDNQNMNVPRNFERPGYSRRHLD 912

  Fly  1181 RSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWF--VSYR-- 1241
             |...||.::.       .:|||.:..||:....|.::|||..||  ||..|..:..  :|:.
Mouse   913 -SSFNAGWSLY-------IQQFRAMFIKRVMFSWRYWKLLLLQLL--ALLGLMYLLIKGISFSVP 967

  Fly  1242 --------LEDDFDTVLPLSRSLYPQTAQFLSHERATSFSEK----------LYPQLRTSCDHLG 1288
                    ||...:|::|.|.|..|...|.|:....|....|          :...|.||.|.:.
Mouse   968 KEPARVMDLEQYGETIVPFSVSGDPNLTQILTKNLETMLKAKKQKIHEVQGDMKNYLLTSKDCIY 1032

  Fly  1289 ECRV-----FNTSQQSYDWVLNSWGEYSERRYGGYGLNGSGATVWYNNKGYHSMMAWLNDLNSEL 1348
            .|.|     ..|.::::                         ..|:||:.||:....|:.|:: :
Mouse  1033 SCIVAFSLDVTTEEKTF-------------------------IFWFNNEAYHAAPLSLSILDN-I 1071

  Fly  1349 LRTTMNDSESSILTLNEP-----WKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLV 1408
            :...::..:::|...|.|     .|....|.|.|.|       .:||.||....:..:...:..|
Mouse  1072 IYKYLSGPDATITVSNNPQPQRVTKDKSNERSISGI-------QIVFNLLFGMSIFTSGFCLMTV 1129

  Fly  1409 NERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLS 1473
            .|||:..|..|.:.||..:.:||.||:||.::..:..::.|||.|...:.:.:::...:..:.:.
Mouse  1130 TERVSKAKHIQFVSGVYTLNFWLSALLWDLIIHFVACVLLLVVFLYTDVDILLEKYHFLDTMFIL 1194

  Fly  1474 LAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQA 1538
            :.|.::.:|.:::....:::|:.|.:.||..|..:..:::.:..::.::.|  .....::.:..:
Mouse  1195 MLFGWSIIPFIYLLSFWYNNSTNAYIKIFVFNHCLGFISIIVDAVVQIIPD--IKTSTKNLILNS 1257

  Fly  1539 FLIFPIHALGD------------------GFLEL---CKNYMVALVFRRYDIDSYKHPLASDLLG 1582
            .|:.||:..|.                  |::..   ||:.::       ||..|.  :....:|
Mouse  1258 MLLLPIYNFGMSIYKYYNIHEIRKLCSSLGYINTIPSCKSQII-------DIPIYS--MNQKAIG 1313

  Fly  1583 RHFTALLLVGVAALIINVLIE---WHL-----------LRRLWQRVERLLDCT-YRRELDKLGQL 1632
            ||.||:...|:...|:.:|:|   |:|           :.|::.:.....:.: |..|.|...:.
Mouse  1314 RHVTAMAATGLIYFILIILLETTSWNLKIFIYRYVLFGIYRIFYKARMSEELSGYSEEEDVQNER 1378

  Fly  1633 KLVNIQSIFKSCVDTGEAVRAENLWLAYRR--GHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFK 1695
            :.: :...::|...|   |..:.|...|.:  ...||||::.::|:.|||||||.|||||:|.||
Mouse  1379 ETI-LNHPWRSLNST---VLIKELIKIYFKIPPTLAVRNISVAIQKEECFGLLGLNGAGKTTTFK 1439

  Fly  1696 LLTGQLQPDVGQIYFE-----------QPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLD 1747
            :|||:.....|.::.|           :..:.||||.:.|...:|:.|.:..|.|:.||  ..:.
Mouse  1440 ILTGEEIATSGDVFIEGYSITRNILKVRSKVGYCPQFDALLDYMTSREILTMYARVWGIPENSIR 1504

  Fly  1748 QFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATI 1812
            .::|.:|....|:|..|..:..|||||:|:|:.|:...|.:..|.:|||::.|||:.|.|::..:
Mouse  1505 AYVDNLLKMLYLKPQADKFIYTLSGGNKRRLSTAIAIMGNSTVVFLDEPSTGMDPLARRMLWNAV 1569

  Fly  1813 EQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFC------G 1871
            .:...:.:.:::||||:.|.|.||.|:|::..|:.:...|||.||::.|..|.:|...      .
Mouse  1570 IKTRESGKVIIITSHSMEECEALCTRLAIMVQGKFVCLGSPQHLKNKFGNIYTMTIKFKTDTDDN 1634

  Fly  1872 PAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAIL--CDVCVNVARF 1934
            ..|.  |...:.:..||:...|.....|.:.:..:: .|.|      ::|.||  .....|:..:
Mouse  1635 TVQD--LKDFIAEVFPGSDLKQENQGILNYYIPSKN-NSWG------KVFGILEKAKEDYNLEDY 1690

  Fly  1935 SLSRCRFETVFERILDSSESNGSNGVHK 1962
            |:|:...|.||  :..::..|..:|..|
Mouse  1691 SISQITLEQVF--LTFANPDNPRSGYEK 1716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	34/186 (18%)
		ABC_subfamily_A	859..1073	CDD:213230	78/242 (32%)
		drrA	865..1162	CDD:130256	97/342 (28%)
		ABC2_membrane_3	1230..1601	CDD:289468	82/423 (19%)
		Mem_trans	1436..>1552	CDD:304621	19/133 (14%)
		ABC_subfamily_A	1651..1857	CDD:213230	76/220 (35%)
		drrA	1666..1945	CDD:130256	93/299 (31%)
Abca14	XP_017167760.1	rim_protein	<128..1709	CDD:130324	376/1579 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750