Protein Alignment CG34120 and abca3b

DIOPT Version :9

• Sequence 1: NP_001285513.1
• Gene: CG34120 / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: XP_009297489.1
• Gene: abca3b / 564344
• ZFINID: ZDB-GENE-050517-2
• Length: 1703
• Species: Danio rerio
• Alignment Length: 1768
• Identity: 444/1768 - (25%)
• Similarity: 731/1768 - (41%)
• Gaps: 401/1768 - (22%)

  Fly   440 PADSMVIDLKYHRGFVQLKQMVDLGIIKSKREEAGFAPEED-------GPESGRSLSGL-----F 492
            ||::.|:.        |:.|.|...:....:...||..||.       .||||:.|:.:     |
Zfish    80 PANASVVQ--------QIAQDVQQNLQSCIKNVRGFETEEQFEEFVKTDPESGKILAAIVFEHPF 136

  Fly   493 SIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSS-LD------------- 543
            |          .||:...|.:........:|:   :|...|.:.::|:: :|
Zfish   137 S----------HDDEPLPLQVSYHLRFTYSPR---NAPAREKSELNPNNDMDWHTLSLFPLFQMP 188

  Fly   544 ---------GVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKN 599
                     |.|....|....|...:.|..:::..|     ||....||
Zfish   189 GPREQHDPHGGTPGYYREGFLQVQYAVDRAIMMAYN-----RSAAMALF---------------- 232

  Fly   600 KFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGL-VVFVALS-VRERIWMRESRNSM 662
                |..|....:||||||:.|||    .||...|:..||.| ..:.||: ||..:..:|.:...
Zfish   233 ----DQTQVLLSRFPYPAFIYDVF----ILAIQNQLPLLLVLSFTYTALNIVRAVVQEKERKLKE 289

  Fly   663 LMRSMGLKAHSELVAWALMSFLELCVIFALISGVLY------SGGILGYTNWFFMMFYCLSFGLC 721
            .||.|||.......||.||.||.|.:....:: ||:      :|.:|.|::...:..:.|.|.:.
Zfish   290 YMRMMGLSNWLHWSAWFLMFFLFLSISIFFVT-VLFCVKVSPNGAVLTYSDPTLVFVFLLVFAIS 353

  Fly   722 LISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGE 786
            .|:|.:|.:.||:.||:.|.|...::|:|..|::.:......||..:.....|....|.|.| .:
Zfish   354 TINFSFMISVFFSRANVAAAAGGFIYFLSYLPYVFLWPRYDLLSHAQKVSACLISNVAMAMG-AQ 417

  Fly   787 LIRM-ELQQEGLTVRHLIQVGPARSECAMALL--MFLLDLLLYAVI------------GLAYQRY 836
            ||.| |.:..|:...:|.:......:.::|.:  :.|||.|||.::            |:....|
Zfish   418 LIGMFEGKGTGIQWHNLFEAVTVDDDFSLAQVIGLLLLDALLYGLVAWYVEAVFPGEYGVPQPWY 482

  Fly   837 ------------------KKTDNYSFVKVSRSQLDGKLGASLV------NVSKLY----GSKCAV 873
                              :|.|.....|.|:.:...:..|.||      .::|::    .||.||
Zfish   483 FFILPSYWCSSPRVAFLKEKEDEEDAEKASKGEFMEEEPAGLVAGVKIKRLAKVFKVGNKSKEAV 547

  Fly   874 SNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG----------EHQVGVCWQD 928
            .:|:|:....|::.|||.|||||:|.:.:|||....|||:..:.|          ...:|:|.|.
Zfish   548 RDLTLNMFEGQITVLLGHNGAGKTTTLSMLTGLFPPSSGRAYINGYDICQDMALIRRSLGLCPQH 612

  Fly   929 NILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLC 993
            ::|...||.||||..|.|:|..|.     |:|..||.:.::.||.....:.....||||.:|:|.
Zfish   613 DVLFDNLTVREHLLFYTQLKGYPR-----EKIPGEVDRIIRILNLEDKRNAKCKTLSGGMKRKLS 672

  Fly   994 VAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNG 1058
            :.||.|....||:||||.:|:|..||:..|.|::..::||.::..|||||||..|.|.:.||.:|
Zfish   673 IGIALIGDSKVVMLDEPTSGMDPSARRATWDLLQGEKRGRTILLTTHFMDEADLLGDRIAIMASG 737

  Fly  1059 RIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPH-------- 1115
            .:....|...|:....:.|.:.:.......|:.:.:.....:|...:..|..|:..:
Zfish   738 ELQCCGSPLFLKNKYGAGYHMVIVKDAFCNVSEITRLVHMYVPDATLESSAGAELSYILPKESTS 802

  Fly  1116 -------SLTIN------ASYAEHLTPGAVEFL---ELLQSQVTAGSISDVELTTSSSLEQEFEQ 1164
                   .|.:|      |||...:|.....||   :|:.|.:      |::.....:|:.:.|:
Zfish   803 RFELLFAELEMNRDELGIASYGASVTTMEEVFLRVGKLVDSSL------DIQAIQLPALQYQHER 861

  Fly  1165 LNRNGEDAGPRRPASDRSGVVAGPAMITDEPPTA-------------------CKQFRLLMGKRL 1210
            .:.:.        ..|.|..::|...:||...:.                   .:||..:..||.
Zfish   862 RSHDW--------TMDDSSSISGMTDVTDFTDSCTMISEDGSNIKLNTGARLYMQQFYAMFLKRA 918

  Fly  1211 RHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDTVLPLSRSLYPQTAQFLSHERATSFSEK 1275
            .:..||:::::...|:|.:|.:.|               |.::||| |.     ||..
Zfish   919 LYSWRNWKVMVAQFLVPLIFTVLA---------------LVVARSL-PS-----SHSS------- 955

  Fly  1276 LYPQLRTSCDHLGE------------------CRVFNTSQQSYDWV----LNSWGEY----SERR 1314
              ||||.:....|:                  ..::.|...|.:.:    :..:.||    ::|.
Zfish   956 --PQLRLALKQYGQTHVPVAVEANAGPLASLLAEIYTTQLPSQNAIAAPNITDFSEYVLYNAQRE 1018

  Fly  1315 YG--------GYGLNGSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGF 1371
            .|        |.....|....::||:|||:....|..:::.|.: .:....:||.|.|:|.....
Zfish  1019 GGAFNEHCVVGAAFRSSDVIGYFNNQGYHTPATALMLVDNALFK-LLAGPNASIQTGNDPMPRNV 1082

  Fly  1372 AELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVW 1436
            :|.:.|.:.......::...|:.....:.::.::.||:||....|..|::.||....:|..||:|
Zfish  1083 SETAQSQLSESQTGFAIAINLMYGMASLASTFALLLVSERSVKSKHVQQVSGVYLTNFWFSALLW 1147

  Fly  1437 DYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSI 1501
            |.:..:|..::.|||..:|.:..||.:..||.::.|.|.:.:|.:|.:::...:||.::.|...:
Zfish  1148 DLINFLLPCLLMLVVFRVFSVKAFVAQNHLVDVLFLLLLYGWAVIPLMYLMSFLFSTAATAYTRL 1212

  Fly  1502 FCANLIVPLVTMGIILILGVVGDGPAWD--DWRHALNQAFLIFPIHALGDGFLELCKNY------ 1558
            ...|:|....|...:.|:.:    |..:  ...|.|::.|||||.:.||..|.|..:||
Zfish  1213 TIFNIISGTATFLAVTIMTI----PELNLLHLSHLLDKVFLIFPNYCLGMSFTEFYQNYEMITFC 1273

  Fly  1559 ----MVALVFRRYDIDSYK---HPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLW----Q 1612
                :...:.:.|:| :|:   ..:....:||...||.|.||..:|:..|||...:|.|.    :
Zfish  1274 TSSPLAKYICKYYNI-TYQMNYFSMEEPGVGRFLVALSLQGVVFIILLFLIELRCIRLLLNLCRR 1337

  Fly  1613 RVERLL-----------DCTYRRELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGH-- 1664
            |.:.||           |....|:       :::..|.:.:|.|  |..:..:.|...|..|.
Zfish  1338 RKKALLLAEEALQPEDRDVAEERK-------RVLECQPVVESMV--GSPLVVQELSKMYSGGQSL 1393

  Fly  1665 YAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFE-----------QPGISYC 1718
            .||..::.:|.:||||||||.|||||:|.||:|||......|..:.:           |..|.||
Zfish  1394 LAVDRLSLAVGKGECFGLLGFNGAGKTTTFKMLTGDESITSGDAFIDGYSILTDVKKVQQRIGYC 1458

  Fly  1719 PQSNPLDPLLTTTECIRFYGRLRGIRD--LDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVA 1781
            ||.:.:...:|..|.:..|.|||||.:  :...::.||.:..|.|:.|..||:.||||:|||:..
Zfish  1459 PQFDAVLDHMTGRETLSMYARLRGIPEKYVTACVENVLRSLLLEPHADKLVRSYSGGNKRKLSAG 1523

  Fly  1782 VTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQ 1846
            :...|..|.:.:|||::.||||.|.:::..|.:...:.:|:::||||:.|.|.||.|:||:..||
Zfish  1524 MALIGGPPVIFLDEPSTGMDPVARRLLWDAITRTRESGKAIIITSHSMEECEALCTRLAVMVNGQ 1588

  Fly  1847 VIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSL 1911
            .....|||.|||:.|..|.:                                   |.:||....|
Zfish  1589 FKCLGSPQHLKSKFGSGYTL-----------------------------------LAKVRVETEL 1618

  Fly  1912 GDAPLLSELFAILCDVCVNVARFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVAKNDLPSK 1976
            .::.|  :||.                           |..||.....:.||:.|.:....|..|
Zfish  1619 EESDL--QLFK---------------------------DFIESTFPGSLLKDEHQGMVHYHLTDK 1654

  Fly  1977 S---PAVGGTLET 1986
            :   ..|.|.|||
Zfish  1655 TLTWAQVFGVLET 1667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	45/146 (31%)
		ABC_subfamily_A	859..1073	CDD:213230	83/233 (36%)
		drrA	865..1162	CDD:130256	98/334 (29%)
		ABC2_membrane_3	1230..1601	CDD:289468	95/419 (23%)
		Mem_trans	1436..>1552	CDD:304621	32/117 (27%)
		ABC_subfamily_A	1651..1857	CDD:213230	82/220 (37%)
		drrA	1666..1945	CDD:130256	91/291 (31%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001	6/22 (27%)
		AAA	<122..1695	CDD:333001	433/1718 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850