DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34120 and abca1a

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:NP_001296394.1 Gene:abca1a / 558924 ZFINID:ZDB-GENE-031006-12 Length:2268 Species:Danio rerio


Alignment Length:2494 Identity:551/2494 - (22%)
Similarity:929/2494 - (37%) Gaps:781/2494 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPAAFSY 77
            ||.|:...|.||....|:.:.||:.:|.:|..:||.|...|...|.:|.:.:|:.. .:|.....
Zfish    10 LLWKNFTYRRRQTIQLLVEIIWPLFIFFILISVRLYYPPYEQHECHFPNKAMPSAG-TLPWVQGI 73

  Fly    78 ICSIENRC-----------------------------------QPAHPYE--------------- 92
            ||:..|.|                                   |....:|               
Zfish    74 ICNANNPCFRYPTPGETPGVVGNFNDSIISRLFTDAKKILLYSQQDKSFEGFKGLVRALRKLQRN 138

  Fly    93 -------EYSHWKEA-----------PLHSVIDVVNAFVTDERLHKAVVELAEKANFVSAITTLI 139
                   ::.|..|.           |.|:|..:|.|.|   .|.|.:::     .|...:|.|.
Zfish   139 TEGFKLKDFLHDNETLSAFLEKNATLPKHAVRQIVEANV---NLEKVLIK-----GFGVHLTDLC 195

  Fly   140 TSDRFDIIRSNISEIISLVPEIERRMNYSFDIKHLFSNRETFVKLGVLLCGHP-----------F 193
            .|       :::.|.:::..:         |:..|..|         ::|..|           .
Zfish   196 NS-------TSLEEFVTIADK---------DVSQLTQN---------IICQSPADWLNNAEQHFL 235

  Fly   194 PNTDTIPLVNEILESE-----DFSQANDA----------EIDAMPTRRRRRYEDL---------- 233
            .|.|.:..:.:.::|:     |.|.|.|:          |:.:|.:.|..|.|.|          
Zfish   236 SNLDFLKPIRKDVKSDPKIIKDVSIATDSLLESLGALAVELASMKSWRDMRNEILYLTGNSTQSP 300

  Fly   234 ------------------------------------------PTDWRP--------TKYCKRLYR 248
                                                      .:|..|        |.||..|.:
Zfish   301 NHMYQAVSRIVCGHPEGGGLKIKSLNWFEDNNYKALFGNNGNDSDSEPASVYDNSSTPYCNNLMK 365

  Fly   249 DVTSTNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEELDRLKQL------------- 300
            .:.|:...::.|..:||::.|:|||||....|:.::...|.:|:||..|:.|             
Zfish   366 GLESSPISRMIWRALKPLLMGKILYTPDTPATQRIIHEVNKTFQELGVLRDLGGMWEEMRPKIWN 430

  Fly   301 ----SRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDIGEIERVF----EYIRTNQ 357
                |.....:.|.|..||:.:  |.|    ||      |.|.::.:.::.|..    |..|.:.
Zfish   431 FMENSEEMDLVRTLLQNNASAR--FFN----AK------LSGTEWRVEDVSRFLSKSSEDTRPHG 483

  Fly   358 LIY----------DILTTVADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLAAL-------N 405
            ..|          ..:.|::..|:||:.|:.|.|.:.|.|..::..|..::.|.|.:       |
Zfish   484 TAYTWREVFNETDQAIQTISRFMECVNLDKLEPVANEERLVNKSMRLLDDRKFWAGIVFPDMQSN 548

  Fly   406 LEDVGLKQASYRLHMDTDNTQPTFENRNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKSK 469
            ..|:.| ..:|::.||.||.:.|.:.::.:|.|||......||:| ..||..|:.:::.|||   
Zfish   549 TSDLPL-NVNYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDLRYIWGGFTYLQDVIEHGII--- 609

  Fly   470 REEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEA 534
                            |:|:|                     |.|::|                 
Zfish   610 ----------------RALTG---------------------SKEKTG----------------- 620

  Fly   535 TTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKN 599
                                                                             
Zfish   621 ----------------------------------------------------------------- 620

  Fly   600 KFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSMLM 664
                    .|.:|.|||.:::|:|.|  .:::.:.:...|..:..||:.::..::.:|:|....|
Zfish   621 --------VYIQQMPYPCYVDDIFLR--VMSRSMPLFMTLAWMYSVAIIIKGVVYEKEARLKETM 675

  Fly   665 RSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMC 729
            |.|||......::|.:.|.:.|.:..||:..:|..|.:|.|::...:..:..||.:..|..|::.
Zfish   676 RIMGLDNGILWLSWFISSLIPLLISAALLVLILKMGNLLPYSDPGVIYLFLSSFAVVTIMQCFLI 740

  Fly   730 TNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKG----------- 783
            :..|:.||:.|....:::|....|:::.:.:...:......:|.|....||..|           
Zfish   741 STLFSRANLAAACGGIIYFTLYLPYVLCVAWQNYVGFGAKIVVSLLSPVAFGFGCEYFALFEEQG 805

  Fly   784 ----WGELIRMELQQEGLTVRHLIQVGPARSECAMALLMFLLDLLLYAVI------------GLA 832
                |..|:...:|::...:        ..|.|.|     |.|.:||||:            |:.
Zfish   806 VGIQWSNLLSSPMQEDSYNL--------TTSICLM-----LFDSVLYAVMTWYIEAVFPGQYGIP 857

  Fly   833 YQRY---------------------KKTDNYSFVKVSRSQLDGKLGASLVNVSKLYGS-KCAVSN 875
            ...|                     .:.:|...|.:.........|..:.|:.|:|.: |.||..
Zfish   858 RPWYFPFTKSYWCGEKCGWTTSVPSNRKENAEAVCIEEEPAHIDPGVYIENLMKIYSNGKVAVDG 922

  Fly   876 LSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGE----------HQVGVCWQDNI 930
            |:|.|...|::..||.|||||:|.:.:|||....:||...:.|:          ..:|||.|.|:
Zfish   923 LTLGFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIQGKDIRTDLNAIRQNLGVCPQHNV 987

  Fly   931 LIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVA 995
            |...||..||:..||::|   |.|  .|:::||:.|.:..|......:..|.|||||.:|:|.||
Zfish   988 LFSMLTVEEHIWFYARLK---GLS--AEKVKSEMEQIVMDLGLPHKRTSRSNQLSGGMQRKLSVA 1047

  Fly   996 IAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRI 1060
            :||:....|||||||..|||..||:.||.|:.:.||||.:|.:||.||||..|.|.:.|:.:|::
Zfish  1048 LAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKL 1112

  Fly  1061 IAQHSRDSLQRLCTSNYSIRLRCAD--------ATGVTFVIQKAQQLLPQTQVTHSGA------- 1110
            ....|...|:....:.|.:.|...|        .|..:.|......|.....|:.|.:       
Zfish  1113 CCVGSSLFLKTQLGTGYYLTLVKKDFDLSASSCRTSSSTVSYSKGSLKKDDSVSESSSDAGLGSD 1177

  Fly  1111 ---------------------------ADYPHSLTINASYAEHLTPGA-VEFLELLQSQVTAGSI 1147
                                       .|..|.:|....| |....|| ||....:..::|..||
Zfish  1178 HESETTTIDISLISNVIFKHVPTARLVEDLGHEITYVLPY-ESAKDGAFVELFHEIDDRLTDLSI 1241

  Fly  1148 SDVELTTSSSLEQEFEQLNRNGEDAGPRRPASDRSGVVAGPAM----------------ITD--- 1193
            |...: :.::||:.|.::   .||.|.....||  |.:  ||.                .|:   
Zfish  1242 SSYGI-SDTTLEEIFLKV---AEDCGVDAETSD--GTL--PARRNRRHAFGDHQSCLKPFTEDDF 1298

  Fly  1194 -------EPPT----------------------ACKQFRLLMGKRLRHLSRNYRLLLYVLLLPAL 1229
                   :|.:                      ..:||..|:.|||.:..|:.:.....::|||:
Zfish  1299 DFNDSEGDPESRETDWLDGADGKGSYQVKGWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAV 1363

  Fly  1230 FELCAMWFVSYRLEDDFDTVLP---------LSRSLYPQTAQFLSHE------------------ 1267
            |...|:         .|..::|         |..|:|.:...|:|::                  
Zfish  1364 FVCIAL---------VFSLIVPPFGKYPSLALEPSMYEEQFTFISNDAPEDRHTNRLLDALKDSP 1419

  Fly  1268 ---------------------------RATSFSEKLY-----------PQLRTSCD----HLGEC 1290
                                       ..|...|.::           |....||:    .|.||
Zfish  1420 AYTDQCTDGKNTASRSCPIKDGEWLVPEVTESIEAIFLNGNWSMENPSPLCECSCEGRKKMLPEC 1484

  Fly  1291 ------------------RVFNTSQQSY-DWVLNSWGE-----------YSERRYGGYGLN---- 1321
                              .:.|.|.::. |:::.::.:           .:|.||||:.|.    
Zfish  1485 PPGAGGLPPPQIKVTHDETLQNLSGRNISDYLVKTYAQIIGKSLKNKLWVNEFRYGGFSLGARNT 1549

  Fly  1322 --------------------------------GSGAT------------VWYNNKGYHSMMAWLN 1342
                                            ||.:|            :|:||||:||:.::||
Zfish  1550 QALPPGDELTDAISHIRSRFSLESGTAADRFLGSLSTFIRGLDTNNNVKIWFNNKGWHSIGSFLN 1614

  Fly  1343 DLNSELLRTT----MNDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASG 1403
            .:|:.:||..    ::.|:..|...|.|..|...:||..:::..:.|..:...::.|...|.||.
Zfish  1615 VMNNAVLRANLPPGLDRSKFGINAFNHPLNLTKEQLSHVALMTTSVDVLVSICVIFAMSFVPASF 1679

  Fly  1404 SVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVG 1468
            .|:|:.||||..|..|.:.||....|||...|||....::...:.:::.:.|....:|....|..
Zfish  1680 VVFLIQERVNKAKHMQFISGVQPFLYWLANFVWDMCNYIVPATLVIIIFVCFQQEAYVSSTNLPV 1744

  Fly  1469 IIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPL---VTMGIILILGVVGDGPAWDD 1530
            :..|.|.:.::..|.::.|...|...|.|.|.:...|:::.:   |:..::.:.|....|...| 
Zfish  1745 LALLLLLYGWSITPLMYPASFFFKIPSTAYVVLTSVNILIGINGSVSTFVLELFGSNEIGGIND- 1808

  Fly  1531 WRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAA 1595
               .|...|||||...||.|.:::.||..:|....|:..:.::.|||.|::|::..|:.:.||..
Zfish  1809 ---ILKNVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFRSPLAWDMVGKNLFAMAIEGVIF 1870

  Fly  1596 LIINVLIEWHL---LRRLWQRVERL--LDCTYRRELDKL----GQLKLVNIQSIFKSCVDTGEAV 1651
            ..|.|||::..   .|.|..:::.:  .|....||..::    ||..::.::.:.|         
Zfish  1871 FSITVLIQYRFCIKARSLSTKLKPIGEEDEDVARERQRILGGGGQTDILELRQLTK--------- 1926

  Fly  1652 RAENLWLAYRRGHY-AVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFE---- 1711
                   .|:|... ||..:...:..||||||||.|||||::.||:|||......|:.|..    
Zfish  1927 -------VYKRKQKPAVDRLCVGIPPGECFGLLGVNGAGKTSTFKMLTGDSVVTSGEAYLAGNSV 1984

  Fly  1712 -------QPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQV 1767
                   ...:.||||.:.::.|||..|.:.||..|||:  :::.:..|..:....|..|.|...
Zfish  1985 LTEIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPEKEVCKVADWGIRKLGLMKYVDKAA 2049

  Fly  1768 RNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEI 1832
            .:.||||.|||:.|:...|..|.|.:||||:.|||..|..::..|..::...|:|||||||:.|.
Zfish  2050 GSYSGGNMRKLSTAMALIGGPPVVFLDEPTTGMDPKARRALWNCILSIIKEGRSVVLTSHSMEEC 2114

  Fly  1833 EHLCQRVAVLRAGQVIASDSPQRLKSEHG-GYYAVTCFCG--PAQQAILSRSLNQRLPGARDLQH 1894
            |.||.|:|::..|:.....|.|.||::.| ||..:....|  |..:.:: ..:.:.|||:...:.
Zfish  2115 EALCTRMAIMVNGRFRCLGSVQHLKNKFGDGYTIILRVAGADPRLEPVM-EFIERELPGSTLKEK 2178

  Fly  1895 YAHSLRFLVRVRSPGSLGDAPLLSELFAILC--DVCVNVARFSLSRCRFETVFERILDSSESNGS 1957
            :.:.|::    :...||..   |:.:|.||.  ...:::..:|:|:...:.||....        
Zfish  2179 HRNMLQY----QLSSSLTS---LARIFNILSKNKEQLHIEDYSVSQTTLDQVFVNFA-------- 2228

  Fly  1958 NGVHKDQQQQVAKNDLP-SKSPAV 1980
                |||..:....|:. :|:.||
Zfish  2229 ----KDQSDEDHLKDISMNKNDAV 2248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 32/138 (23%)
ABC_subfamily_A 859..1073 CDD:213230 88/224 (39%)
drrA 865..1162 CDD:130256 110/350 (31%)
ABC2_membrane_3 1230..1601 CDD:289468 107/524 (20%)
Mem_trans 1436..>1552 CDD:304621 27/118 (23%)
ABC_subfamily_A 1651..1857 CDD:213230 78/219 (36%)
drrA 1666..1945 CDD:130256 95/296 (32%)
abca1aNP_001296394.1 rim_protein 1..2233 CDD:130324 547/2477 (22%)
ABC_subfamily_A 904..1122 CDD:213230 87/222 (39%)
ABC_subfamily_A 1919..2139 CDD:213230 79/235 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 159 1.000 Domainoid score I4043
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.820

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