Protein Alignment CG34120 and Abca6

DIOPT Version :9

• Sequence 1: NP_001285513.1
• Gene: CG34120 / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: XP_006247716.1
• Gene: Abca6 / 303639
• RGDID: 1308998
• Length: 1630
• Species: Rattus norvegicus
• Alignment Length: 1592
• Identity: 359/1592 - (22%)
• Similarity: 637/1592 - (40%)
• Gaps: 411/1592 - (25%)

  Fly   599 NKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSV-RERIWMRESRNSM 662
            |.|.:..:.|.:|         |:|:..:::.  ..:.|....:.|.:.|| :||...:|
  Rat   207 NAFNMKTLPFISK---------DIFQYEIFIL--FCLLYFSSFIYFASRSVTKERKHSKE----- 255

  Fly   663 LMRSMGLKAHSELVAWALMSFLELCVIFAL-ISGVLYSGGILGYTNW--FFMMFYCLSFGLCLIS 724
            .|:.|||:..:..::|.|: ::....||:: |:.::.|..|:..|.:  .|.:|:.  :||.:|:
  Rat   256 FMKVMGLQDSAFWLSWGLI-YVGFIFIFSVFIAVIITSTRIIVMTGFLVIFTLFFL--YGLSVIA 317

  Fly   725 FCYMCTNFFNSANIGAVASALLFFISL---CPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGE 786
            ..::.......|   .:.:..:|..:|   |....||..:...|:  .:::.:....||..|..:
  Rat   318 VTFLMAVLLQKA---IITNLFVFLFNLFWGCVGFTVLHKELPSSL--EWVLSICSPFAFTSGMTK 377

  Fly   787 LIRMELQQEGLTVRHLIQVGPARSECAMALLMFLL--DLLLYAVIGLAYQRY------------- 836
            :|.:|....|     ::...|:.....|..:.|:|  |.|||.|:.|.:.:.
  Rat   378 IIFLEYNLNG-----VVFPDPSGESYVMIAVFFILAFDGLLYLVLALYFDKILPCGADRRAAPLF 437

  Fly   837 ---------KKTDNYSFVKVSRSQLD-----------------GKLGASLVNVSKLYGSKC---- 871
                     |:|   |..||:...:|                 ||....:.|:.|.|..|.
  Rat   438 FLNPVSCFRKRT---SRNKVTERDIDPELPSDEYFEPVDPEYQGKEAIRIRNIRKEYKGKSGKVE 499

  Fly   872 AVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGEH------------QVGV 924
            |:..|..|...:|::.:||..|||||:|:.:|.|....:||...:..::            .:||
  Rat   500 ALKGLFFDVYESQITAVLGHGGAGKSSLLNILNGLSVPTSGLATVYNKNLSEMQDLKEIRKMIGV 564

  Fly   925 CWQDNILIPTLTAREHLQLYAQIK--IPPGGSGGVEEIRSEV-AQTLQSLNFGKHESYPSWQLSG 986
            |.|.|:....||.:|:|.|:|.||  :|...:..|::|.||: .||:|. ...:|       ||.
  Rat   565 CPQHNVQFDALTVKENLTLFANIKGIVPQSVAQEVQQILSELDMQTIQD-ELAEH-------LSE 621

  Fly   987 GYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDS 1051
            |.:|:|...:|.:..|.:::||||..|:|..:|:.:|..::..|..|.::|:|.|.|||..|:|.
  Rat   622 GQKRKLTFGVAILGDPRILLLDEPTAGLDPFSRQRVWGFLKERRADRVILFSTQFTDEADILADR 686

  Fly  1052 LVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHS 1116
            .||:.||                     .|:|   ||.:..:::...|            .|..|
  Rat   687 KVILSNG---------------------ALKC---TGSSVFLKRKWGL------------GYHLS 715

  Fly  1117 LTIN--------ASYAEHLTPGA----------------------VEFLE---------LLQSQV 1142
            |.:|        .|:..|..|||                      .||..         |:..:|
  Rat   716 LFMNETCDSEQLTSFINHHIPGAKLKAKTKEKLVYTLPLEKTSKFPEFFSDLDKYSGQGLMNYEV 780

  Fly  1143 TAGSISDV--ELTTSSSLEQEFEQLNRNGE-----------DAGPRRPASDRSGVVAGPAMITDE 1194
            :..::::|  .|....|..|:||:    ||           :..|  |:..::........:...
  Rat   781 SMSTLNEVFMNLEGEPSTTQDFEK----GETLTDSDSLNEMEVAP--PSLSKAQKTMSAMSLWRM 839

  Fly  1195 PPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDTVLPLSRSLYPQ 1259
            ...|..:.|:|..:|.|.....:..||.:.|:|.:.|..|...:..:...:|.|      .||
  Rat   840 QVCAIARLRVLKLRRERKAFLTFLPLLGISLIPLITEYMANALIEVKTNWEFKT------DLY-- 896

  Fly  1260 TAQFLSHERATSFSEKLYPQ-LRTSCDHLGECRVFNTSQQSYDWVLNSWGEYS--------ERRY 1315
               |||..:        .|| ||||      ..|.|.::.:.:..:.|....:        |.|.
  Rat   897 ---FLSPGQ--------LPQGLRTS------LLVINNTESNIEDFVQSLKHQNIVLEVDDFENRN 944

  Fly  1316 GGYGLNGSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGFAELSTSSIL 1380
            ....|:.:||.:....:..:...|..|..........||...:.||.:          |:.:..:
  Rat   945 ATESLSYNGAIIVSGRQKDYRFSAVCNTKRLHCFPILMNVISNGILRM----------LNHTQHI 999

  Fly  1381 RQAGDGSMVFILLIAFGLVVASGSVYLVNERVN-----------GEKLQQRL-----------CG 1423
            |...|.....|:::.||::.||.|:..:...|:           .:|...:|           ||
  Rat  1000 RLEEDVLSSGIVVVWFGILEASLSILFIVCSVSPHIAMSSISDFKKKADSQLWISGLYPSAYWCG 1064

  Fly  1424 VSAVTYWLVA--LVWDYL---------VMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFS 1477
            .:.|...|::  |:..|:         :.:.|.||..:|:|.||.        ...::.|:...|
  Rat  1065 QALVDITLLSGILLTGYITLYTTKLMHIYLTGEIVLSIVLLAFGC--------AASLVFLTYVIS 1121

  Fly  1478 FACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLI- 1541
            |       |..|...:|.:..:..|              :::.::.|....|.:    |:|.||
  Rat  1122 F-------VFGKKRKNSGLWSICFF--------------IVITIMFDTVLMDPF----NEALLIS 1161

  Fly  1542 -------FPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIIN 1599
                   |.::||           ::.|..|.|   .|.........|       |.|| .|::.
  Rat  1162 AMMLVPSFSLNAL-----------LIVLEMRAY---QYYREFGESKYG-------LSGV-DLLLC 1204

  Fly  1600 VLIEWHLLRRLWQRVERLLDCTYRRELDKLGQLKLVNIQSIF-----KSCVDTGEAVRAENL--- 1656
            ::..:|.|  |:..|.|.|:..|.:.:.:...|..:..||:.     :..||..|.|:||.:
  Rat  1205 LIPYFHTL--LFIFVLRCLELKYGKNVVRKDPLFRIAPQSLHVQPNPEEPVDEDEDVQAERMRTS 1267

  Fly  1657 ----------------------------W-LAYRRGHYAVRNVNFSVQRGECFGLLGKNGAGKST 1692
                                        | .:.||...||||::|.|.:||..||||..|||||:
  Rat  1268 DALSTVNLDEKPAIIASCLHKEYTGQKKWCCSKRRKKIAVRNISFCVNKGEILGLLGPEGAGKSS 1332

  Fly  1693 IFKLLTGQLQPDVGQIYFEQ--------------PGISYCPQSNPLDPLLTTTECIRFYGRLRGI 1743
            ..:::.|.::|..|::..::              ..:.||||.|.|.|:||..|.:..|..::|:
  Rat  1333 SLRMIAGIMKPTAGEVELKELSSAVAHQGEGHGAAKLGYCPQENVLWPILTVKEHLEVYAAVKGL 1397

  Fly  1744 RDLDQF--LDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRD 1806
            |..|..  :.|:::.::|....:||.|||..|..|||..|::..|.:|.:::|||::.:|...:.
  Rat  1398 RKKDAVIAISRLVNAFKLHDQLNVQARNLVVGLTRKLCFALSILGNSPVLILDEPSTGLDVSGKQ 1462

  Fly  1807 MVYATIEQLLL-ARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFC 1870
            .::..|:..:. .::.|:|::|.::|.|.||.|.|::.:|::....|.|.||...|..|.:....
  Rat  1463 QMWQAIQAAVKDNKKGVLLSTHDLAEAEALCDRAAIMVSGRLRLIGSIQHLKRRFGKDYILELRV 1527

  Fly  1871 GP-AQQAILSRSLNQRLP-GARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDV--CVNV 1931
            .. :|:.::.:.:.:..| .||..:.::     |:..:.|  :.|...||:.|..|..|  ..|:
  Rat  1528 KEISQEPLVHKEILRLFPQAARQDRCFS-----LLTYKLP--VTDVHPLSQAFHKLEAVKRGFNL 1585

  Fly  1932 ARFSLSRCRFETVFERILDSSESNGSNGVHKD 1963
            ..:|||:|..:.||   |:.|:......||::
  Rat  1586 DDYSLSQCTLDRVF---LELSKEQELGDVHEE 1614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	32/145 (22%)
		ABC_subfamily_A	859..1073	CDD:213230	71/232 (31%)
		drrA	865..1162	CDD:130256	92/356 (26%)
		ABC2_membrane_3	1230..1601	CDD:289468	79/420 (19%)
		Mem_trans	1436..>1552	CDD:304621	24/132 (18%)
		ABC_subfamily_A	1651..1857	CDD:213230	71/254 (28%)
		drrA	1666..1945	CDD:130256	86/299 (29%)
Abca6	XP_006247716.1	ABC2_membrane_3	35..420	CDD:289468	52/241 (22%)
		ABC2_membrane_4	220..409	CDD:289500	43/208 (21%)
		CcmA	480..795	CDD:224054	91/358 (25%)
		ABC_subfamily_A	482..705	CDD:213230	75/254 (30%)
		ABC2_membrane_3	859..1171	CDD:289468	72/379 (19%)
		ABC2_membrane_4	1007..1178	CDD:289500	38/214 (18%)
		CcmA	1279..1605	CDD:224054	93/335 (28%)
		ABC_subfamily_A	1300..1514	CDD:213230	67/213 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650