DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and Abcg4

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_001100286.2	Gene:	Abcg4 / 300664	RGDID:	1305840	Length:	646	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	157/830 - (18%)
Similarity:	269/830 - (32%)	Gaps:	285/830 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   837 KKTDNY------------------SFVKVSRSQLDGKLGASLVNVSKLYGSKCAVSNLSLDFARN 883
            ||.:|:                  .||::|.|..:|...       :..|.|..:..||..|.|.
  Rat    38 KKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCW-------RKRGYKTLLKCLSGKFCRR 95

  Fly   884 QVSCLLGRNGAGKSTLIKLLTGQIRQS--SGKVLLAGE------HQVGVCW--QDNILIPTLTAR 938
            ::..::|.:||||||.:.:|.| .|:|  .|::|:.|.      .:...|:  ||::|:|.||..
  Rat    96 ELIGIMGPSGAGKSTFMNILAG-YRESGMKGQILVNGRPRDLRTFRKMSCYIMQDDMLLPHLTVL 159

  Fly   939 EHLQLYAQIKIPPGGSGGVEEIRSE-VAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASP 1002
            |.:.:.|.:|:     ...:|::.| |.:.|.:|.........:..||||.|:||.:|:..:.:|
  Rat   160 EAMMVSANLKL-----SEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNP 219

  Fly  1003 SVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKY--LSDSLVIMRNGRIIAQHS 1065
            .|:..|||.:|:|:.:...:..|::.|..|...:..|.....||.  :.|.|.|:..|:.|   .
  Rat   220 PVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQPSAKLFEMFDKLYILSQGQCI---F 281

  Fly  1066 RDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTINASYAEHLTPG 1130
            :..:..|......:.|.|.                     |:...||:
  Rat   282 KGVVTNLIPYLKGLGLHCP---------------------TYHNPADF----------------- 308

  Fly  1131 AVEFLELLQSQVTAGSISDVELTTSSSLEQEFEQLNRNGEDAGPRRPASDRSGVVAGPAMITDEP 1195
               .:|     |.:|...|:......:::        ||......:.:|.....|  ||.....|
  Rat   309 ---IIE-----VASGEYGDLNPMLFRAVQ--------NGLCTMAEKKSSPEKNEV--PAHCPTCP 355

  Fly  1196 P------------TACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDT 1248
            |            :...||.:|..:....:.|                               ||
  Rat   356 PELDPIESHTFATSTLTQFCILFRRTFLSILR-------------------------------DT 389

  Fly  1249 VLPLSRSLYPQTAQFLSHERATSFSEKLYPQLRTSCDHLGECRVFNTSQQSYDWVLNSWGEYSER 1313
            ||...|        |:||.........||.       |:|:
  Rat   390 VLTHLR--------FMSHVLIGVLIGLLYL-------HIGD------------------------ 415

  Fly  1314 RYGGYGLNGSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGFAELSTSS 1378
                      .|:..:||.|:                                  |.|
  Rat   416 ----------DASKVFNNTGF----------------------------------LFF------- 429

  Fly  1379 ILRQAGDGSMVFIL-------LIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVW 1436
                    ||:|::       ::.|.|.:|    ..:.|.:|        ...|...|:|...:.
  Rat   430 --------SMLFLMFAALMPTVLTFPLEMA----VFMREHLN--------YWYSLKAYYLAKTMA 474

  Fly  1437 DY-LVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVS 1500
            |. ..:|..::.|.:|..|.|.|....|         .|.||...:.:..||:.:......|..|
  Rat   475 DVPFQVVCPVVYCSIVYWMTGQPAETSR---------FLLFSALSIATALVAQSLGLLIGAASTS 530

  Fly  1501 IFCANLIVPLVTMGIILILG------VVGDGPAWDDWRHALNQAF--LIFPIHALGDGFLELCKN 1557
            :..|..:.|:..:.::|..|      .:.....|..:...:...|  ||..|:.:..|.|...::
  Rat   531 LQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLED 595

  Fly  1558 YM----VALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIE 1603
            :.    ..::....|::..|..:...:||..|.||.|:....|...|..|
  Rat   596 HCPFRDPQIILHELDVEEAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSE 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230	61/226 (27%)
		drrA	865..1162	CDD:130256	71/309 (23%)
		ABC2_membrane_3	1230..1601	CDD:289468	64/390 (16%)
		Mem_trans	1436..>1552	CDD:304621	25/124 (20%)
		ABC_subfamily_A	1651..1857	CDD:213230
		drrA	1666..1945	CDD:130256
Abcg4	NP_001100286.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000