DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and Abca7

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_997481.1	Gene:	Abca7 / 299609	RGDID:	1303134	Length:	2170	Species:	Rattus norvegicus

Alignment Length:	2405	Identity:	561/2405 - (23%)
Similarity:	898/2405 - (37%)	Gaps:	709/2405 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPAAFSY 77
            ||.|:...|.||....::.|.||:.:|.:|..:|..:...|...|.:|.:.||:.. .||.....
  Rat    10 LLWKNYTYRRRQPIQLVVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAG-TVPWLQGL 73

  Fly    78 ICSIENRC-QPAHPYEE---YSHWKEAPL-------------HSVIDVVNAF------------- 112
            :|::.|.| |...|.|:   .|::|::.:             ||..|::.|.
  Rat    74 VCNVNNSCFQHPTPGEKPGVLSNFKDSLISRLLADAHTVLGGHSTQDMLAALGKLIPVLRAVGSG 138

  Fly   113 -----VTDERLHKAVVELAEKANFVSAITTLI-----TSDRF-DIIRSNISEIISLVPEIERRMN 166
                 ........:|.||.||....:::.|::     :..:| |..|:...|:::|...:|.|
  Rat   139 AWPQESNQPAKQGSVTELLEKILQRASLETVLGQAQDSMRKFSDATRTVAQELLTLPSLVELR-- 201

  Fly   167 YSFDIKHLFSNRETFVKLGVLLCGHPFPNTDTIPLVNEILESE-----------DFSQANDAEID 220
                                .|...|..:..::.|::|.|.|.           ::.:||.....
  Rat   202 --------------------ALLRRPRGSAGSLELISEALCSTKGPSSPGGLSLNWYEANQINEF 246

  Fly   221 AMPTRRRRRYEDLPT--DWRPTKYCKRLYRDVTSTNQGKLTWNTIKPIIQGRILYTPANAMTESV 283
            ..|       |..||  |...:..|......:......:|.|..:||:|.|:||:.|....|..:
  Rat   247 MGP-------ELAPTLPDSSLSPACSEFVGALDDHPVSRLLWRRLKPLILGKILFAPDTNFTRKL 304

  Fly   284 VKFSNASFEELDRLKQLSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDIGEIER 348
            :...|.:||||..|:.|......:                      .|.:.:.:.|..::..:::
  Rat   305 MAQVNQTFEELALLRDLHELWGVL----------------------GPQIFNFMNDSTNVAMLQK 347

  Fly   349 VFEYIRTN------------QLIYDIL--------------------TTVADLMDCVSADRFEAV 381
            :.:...|.            :.|.|.|                    ..:..:::|||.|:.|||
  Rat   348 LLDVEGTGWQQQTPKGQKQLEAIRDFLDPSRGRYNWQEAHADMGRLAEILGQILECVSLDKLEAV 412

  Fly   382 ESVEELHKRAYE-LNQNKLFLAALNLE--------------DVGLKQASYRLHMDTDNTQPTFEN 431
            .|.|.|..||.| |.:.:|:...:.|.              ..|......::.||.|:...|.:.
  Rat   413 PSEEALVSRALELLGERRLWAGIVFLSPEHPLDSSEPPSPTTTGPGHLRVKIRMDIDDVTRTNKI 477

  Fly   432 RNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIK 495
            |::||.|||:...::||:| ..|||.|:.::
  Rat   478 RDKFWDPGPSADPLMDLRYVWGGFVYLQDLL---------------------------------- 508

  Fly   496 QVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRVTTEQTVVS 560
                                   |:||.:                                 |:|
  Rat   509 -----------------------EQAAVR---------------------------------VLS 517

  Fly   561 GDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKR 625
            |              |..|.||                          |.:|.|:|.:::|||.|
  Rat   518 G--------------RDSRAGL--------------------------YLQQMPHPCYVDDVFLR 542

  Fly   626 GLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIF 690
              .|::.:.:...|..:..|||:|:..:..:|:|....||:|||......:.|.|.......|..
  Rat   543 --VLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSA 605

  Fly   691 ALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFI 755
            ||:..||..|.||.|::...:..:..:|.:..::..::.:.||:.||:.|....|.:|....|::
  Rat   606 ALLVLVLKLGNILPYSHPVVVFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYV 670

  Fly   756 IVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSECAMALL--M 818
            :.:.:..:|.:.....|.|....||..|...|..:|.|.:| ...|.:..|||....::|.:  .
  Rat   671 LCVAWRERLPLGGLLAVSLLSPVAFGFGCESLALLEEQGDG-AQWHNLGTGPAEDVFSLAQVSAF 734

  Fly   819 FLLDLLLYAVIGLAY--------QRYKKTD--NYSFVK-------------VSRSQLDGKL---- 856
            .|||.::|   |||.        .:|...:  |:.|.:             ::.:..|.|:
  Rat   735 LLLDAVIY---GLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEE 796

  Fly   857 -------GASLVNVSKLY-GS-KCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSG 912
                   |.|:..:.|.: || :.|:..|:|||....::..||.|||||:|.:.:|:|....|||
  Rat   797 PPPGLVPGVSIRGLKKHFRGSPQPALRGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSG 861

  Fly   913 KVLLAGEHQV-----------GVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVE--EIRSEV 964
            ...:.| |.|           |:|.|.|:|...||..||:..|.::|       ||.  .|.||.
  Rat   862 SASILG-HDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLK-------GVSAAAIDSEQ 918

  Fly   965 AQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERL 1029
            ...::.:.........:..||||.:|:|.|||||:....|||:|||..|||..:|:.||:|:.:.
  Rat   919 EHLIRDVGLIPKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKY 983

  Fly  1030 RQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQ 1094
            |:||.:|.:||.:|||:.|.|.:.::.:|            .||.....:.||.....|....:.
  Rat   984 REGRTLILSTHHLDEAELLGDRVAMVASG------------SLCCCGSPLFLRRHLGCGYYLTLV 1036

  Fly  1095 KAQQLLPQTQVTH--------------SGA----------ADYPH-SLTINASYAEHLTPGAVEF 1134
            |:.|.|    |||              ||:          .|.|| |..:.|..|..:||.|...
  Rat  1037 KSSQSL----VTHDLKGDTEDPRREKKSGSEGKTADTVLTRDGPHRSSQVPAPDAVPVTPSAALI 1097

  Fly  1135 LELLQSQVT------------------AGSISDVELTTSSSLEQEFEQL---------------- 1165
            |||:|..|.                  ||::.....|....|:|:.|:|
  Rat  1098 LELVQRHVPGAQLVEELPHELVLALPYAGALDGSFATVFQELDQQLERLGLTGYGISDTNLEEIF 1162

  Fly  1166 -------NRNGEDAGPRRPA--------------------SDRSGVVAGPAMITDEPPT------ 1197
                   :.:||...||:..                    .:.:.:|..|.......||
  Rat  1163 LKVVEEAHAHGEGGDPRQQQHLLTATPQPHTGPEASVLENGELAKLVLDPQAPKGSAPTTAQVQG 1227

  Fly  1198 ---ACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWF---------------------- 1237
               .|:|.|.|:.||.....|:.|.|...::|||||...|::|
  Rat  1228 WTLTCQQLRALLHKRFLLARRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYGP 1292

  Fly  1238 -VSYRLED--------------------------------------------------DFDTVL- 1250
             ||:..||                                                  |..::|
  Rat  1293 QVSFFSEDAPADPNRMKLLEALLGEAGLQDPSVQGKGSRGSECTHSLACYFTVPEVPPDVASILA 1357

  Fly  1251 -----------------PLSRSLYP-------------------QTAQFLSHERATSFSEKLYPQ 1279
                             |.:|.|.|                   :..|.|:....:.|..|.||.
  Rat  1358 SGNWTPDSPSPACQCSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYPS 1422

  Fly  1280 LRTSCDHLGECRVFNTSQQSYDWVLNSWGEYSERRYGGYGLNG------SGATV----------- 1327
            |            .....::..||       .|.||||:.|.|      ||..|
  Rat  1423 L------------VRRGLKTKKWV-------DEVRYGGFSLGGRDPDLPSGREVVRTVAEMRALL 1468

  Fly  1328 ------------------------------WYNNKGYHSMMAWLNDLNSELLRTTMNDSE----S 1358
                                          |:||||:|:|:|::|..|:.|||..:....    .
  Rat  1469 SPQPGNTLDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLRAFLPSGSVRHAH 1533

  Fly  1359 SILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCG 1423
            ||.|||.|..|...:||.::::..:.|..:...::.|...|.||.::.|:.||:...|..|.:.|
  Rat  1534 SITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSG 1598

  Fly  1424 VSAVTYWLVALVWD---YLVMVLGLIVCLVVI--LMFGMPVFVDRQQLVGIIGLSLAFSFACVPS 1483
            :....|||...:||   |||     .||:||:  |.|....:|..:.|..::.|.|.:.::..|.
  Rat  1599 LPQTLYWLGNFLWDMCNYLV-----AVCIVVLIFLAFQQKAYVAPENLPALLLLLLLYGWSITPL 1658

  Fly  1484 VHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALG 1548
            ::.|...||..|.|.|.:.|.||.:.:.:.....:|.::.|....:..| .|.|.|||||...||
  Rat  1659 MYPASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSR-ILKQVFLIFPHFCLG 1722

  Fly  1549 DGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQR 1613
            .|.:::.:|..:|..|.|.....::.||..|::|::..|::..|...|:|.:|:: |..|.|.|.
  Rat  1723 RGLIDMVRNQAMADAFERLGDKQFQSPLRWDIIGKNLLAMVAQGPLFLLITLLLQ-HRNRLLPQP 1786

  Fly  1614 VERLLDCTYRRELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYR-RGHYAVRNVNFSVQRG 1677
            ..||.......:.|.:.:.:.|.     |.... |:.:...:|...|| :...||.::...:..|
  Rat  1787 KSRLPPPLGEEDEDVVRERERVT-----KGATQ-GDVLVLRDLTKVYRGQRSPAVDHLCLGIPPG 1845

  Fly  1678 ECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYF------EQP-----GISYCPQSNPLDPLLTTT 1731
            |||||||.|||||::.|:::||...|..|:...      ::|     .:.|||||:.:..|||..
  Rat  1846 ECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQEPSAAHRSMGYCPQSDAIFDLLTGR 1910

  Fly  1732 ECIRFYGRLRGIRD---------------LDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVA 1781
            |.:..:.||||:.:               |..:.||...||             ||||:|||..|
  Rat  1911 EHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTY-------------SGGNKRKLATA 1962

  Fly  1782 VTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQ 1846
            :...|....|.:||||:.|||..|..::..:..::...|:|||||||:.|.|.||.|:|::..|:
  Rat  1963 LALVGDPAVVFLDEPTTGMDPSARRFLWNNLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGR 2027

  Fly  1847 VIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSL 1911
            .....|.|.|||..|..:.:|....|.|.......:....|.|...:.:...|||.:   .||.
  Rat  2028 FRCLGSAQHLKSRFGAGHTLTLRVPPDQPEPAIAFIVTTFPDAELREVHGSRLRFQL---PPGG- 2088

  Fly  1912 GDAPLLSELFAILC--DVCVNVARFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVAKNDLP 1974
              ...|:.:|..|.  .....|..||:|:...|.||   |..|:..|.......|:.:..:...|
  Rat  2089 --GCTLARVFRELAAQGKAHGVEDFSVSQTTLEEVF---LYFSKDQGEEEEGSGQETETREVSTP 2148

Fly 1975 1974
Rat 2149 2148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	37/138 (27%)
		ABC_subfamily_A	859..1073	CDD:213230	77/228 (34%)
		drrA	865..1162	CDD:130256	108/354 (31%)
		ABC2_membrane_3	1230..1601	CDD:289468	118/536 (22%)
		Mem_trans	1436..>1552	CDD:304621	38/120 (32%)
		ABC_subfamily_A	1651..1857	CDD:213230	77/232 (33%)
		drrA	1666..1945	CDD:130256	96/306 (31%)
Abca7	NP_997481.1	rim_protein	1..2127	CDD:130324	557/2382 (23%)
		ABC2_membrane	<557..742	CDD:304374	49/185 (26%)
		ABC_subfamily_A	805..1024	CDD:213230	79/238 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1086		9/41 (22%)
		ABC_subfamily_A	1818..2038	CDD:213230	77/232 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2129..2170		3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342214
Domainoid	1	1.000	133	1.000	Domainoid score	I4917
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650