DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and Abca16

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	XP_038957107.1	Gene:	Abca16 / 293444	RGDID:	1563534	Length:	1680	Species:	Rattus norvegicus

Alignment Length:	1464	Identity:	352/1464 - (24%)
Similarity:	600/1464 - (40%)	Gaps:	296/1464 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   598 KNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQG-VQVAYLLGLVVFVALSVRERIWMRESRNS 661
            |..||  |:....::||||:...|   :.|:::.. :.:.::|.....|...:|..::.:|.|..
  Rat   222 KELFE--NIDTLVQRFPYPSHPQD---KLLWISSPFIPLMFILMFSSIVLSIMRSIVFEKEKRLK 281

  Fly   662 MLMRSMGLKAHSELVAWA--LMSFLELCV-IFALISGVLY----SGGILGYTNWFFMMFYCLSFG 719
            .....|||:   ..:.|.  ..:|..|.| |..||..:|:    ...||.|::..|:..:...:.
  Rat   282 EYQLIMGLR---NWIIWMGYFFTFFPLYVAIIFLICILLFIQIVEEPILRYSDCSFIFVFLTCYA 343

  Fly   720 LCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGW 784
            :..|.|.:|.:.||:...:.|.|..||||.|..|:..:..:...|.:.......||...|.|.|.
  Rat   344 IASICFAFMVSTFFSKTRLAASAGNLLFFASFFPYNFISEYYGMLDLTTKITACLSANVALALGI 408

  Fly   785 GELIRMELQQEGLTVRHLIQVGPARSE----CAMALLMFLLDLLLYAVI------------GLAY 833
            ..||::|:|:.|:...:|..  ||..|    ....|.|.|||..||:::            |:..
  Rat   409 NILIKLEIQEIGVKWDNLWT--PANLEDNLNFGYMLGMLLLDAFLYSLVTWYVEAVFPGQCGVPQ 471

  Fly   834 QRYKKTDNYSFVKVSRSQLDGK----------------------------LGASLVNVSKLYGSK 870
            ..|        ..:.||...||                            .|..:.::.|.:.:|
  Rat   472 PWY--------FFIMRSYWFGKPKIRKIGEEAKSIPVVHNCYEAEPSNLEAGIQIKHLHKEFKTK 528

  Fly   871 CAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG----------EHQVGVC 925
            .|::||||:....||:.|||.|||||:|.:.:|||:...:.|:..:.|          ...:|.|
  Rat   529 PAINNLSLNIYEGQVTVLLGHNGAGKTTTLSVLTGRFAATRGEAYINGYNISDNMAEIRKDLGFC 593

  Fly   926 WQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRR 990
            .|.::|...||..|||..|..||..|.....|     |:.:.|...|..::....|..:|||.||
  Rat   594 PQHDLLFDDLTLSEHLFFYCMIKGHPQNINCV-----EINRMLSVFNLQENYHTLSGSVSGGVRR 653

  Fly   991 RLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIM 1055
            :|.:.:|.:....|||||||.:|:|..:|:..|.:::..:|.|.::..||:||||..|.|.:.||
  Rat   654 KLSIILALMGGSKVVILDEPSSGMDPMSRRATWDILQHYKQNRTILLTTHYMDEADVLGDRIAIM 718

  Fly  1056 RNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTIN 1120
            ..|.:....|...|:::..:.|.|.|.......|..:|...||.:|.:.:.:....:.  |..:.
  Rat   719 VRGTLHCCGSSVFLKQIYGAGYHIVLEKEPYCDVDNIIAMIQQHVPGSMLENDIGNEL--SFILP 781

  Fly  1121 ASYAEHLTPGAVEFLELLQSQVTAGSIS-DVELTTSSSLEQEFEQLNRNGEDAGPRRPASDRSGV 1184
            ..|....   ...|.||...|...|..: ...:||   :|:.|.::|        :..|..||..
  Rat   782 KKYVSRF---ETLFTELEMRQKALGIANFGASITT---MEEVFLKVN--------KLAAPQRSIQ 832

  Fly  1185 VAGPAMIT------DEP-----------------------------PTACKQFRLLMGKRLRHLS 1214
            ...|..:|      ||.                             |...:||..:..||...:.
  Rat   833 TIQPYYLTYKKMRQDEQQNVNILRNYNKPIFPYLREIATVKFNTGVPLYRQQFYSMFIKRALFIG 897

  Fly  1215 RNYRLL---LYVLLLPALFELCAMWFVSYRLEDDFDTVLPLSRSLYPQTAQFLSHERATSFSEKL 1276
            ||::|:   :.|:|:...:.|.::..      ||.|         .|:....|||...|.....:
  Rat   898 RNWKLMFLQIIVVLVVTTYLLLSLHL------DDND---------IPERELNLSHYGKTIVPYSI 947

  Fly  1277 YPQLRTSCDHLGECRVF-NTSQQSYDWVLNSWGEY------------------SERRYGGYGLNG 1322
            ......:.:.:...::| .:..||...:......|                  .||       |.
  Rat   948 SGNSDLALNLIKNLKIFLKSKNQSLKKIKGDMNNYILENKDCRTFCIIALSIKVER-------NK 1005

  Fly  1323 SGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGFAELSTSSILRQAGDGS 1387
            :..|:::||:.|||....|:.|:: :|..|::..::||...|:|..|.....:|..:      ..
  Rat  1006 TVLTIFFNNEAYHSPAISLSILDN-ILFMTLSGRDASITAFNKPQPLPHYGSNTVPV------NG 1063

  Fly  1388 MVFILLIAFGL--VVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLV 1450
            :..:..:|||:  ||.|.|:..|.||::..|..|.|.||..:||||.||:.|.:.......|.|.
  Rat  1064 LQIVQCLAFGISVVVGSFSIQTVTERISQAKHIQFLTGVCVLTYWLSALLCDLIFFFFACCVLLG 1128

  Fly  1451 VILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGI 1515
            :.....:..||.....:..|.:.:.:.:..||..::...:|:.|:.|.:.|...|....:.::.|
  Rat  1129 IFRFCQLEAFVVHYNFLDTILIFMLYGWCVVPLTYLGSFLFNSSTAAYIKITLFNYFSTMFSIII 1193

  Fly  1516 ILILGVVGDGPAWDDWRHALNQAFLIFP--IHALGDGFLELCKNYMVALVFRRYDIDSY--KHPL 1576
            ..|:...|:.                ||  ||.|....|....:|.:|:...:| .|.|  |...
  Rat  1194 YTIVQFYGED----------------FPALIHILIKTILMALPSYNLAMSISKY-FDDYEVKRLC 1241

  Fly  1577 ASDL-----------------------LGRHFTALLLVGVAALIINVLIE-----------WHLL 1607
            |.:.                       :|:....|..:|:..|::.:.:|           .::|
  Rat  1242 AREFRSIYMDCSEPFIQNNVYGFGEHGIGKFLITLATMGLVFLLLLLSLESVSSSLKNFVFRNVL 1306

  Fly  1608 RRLWQRVERLL------------DCTYRRELDKLGQ--LKLVN-------IQSIFKSCVDTGEAV 1651
            ...:.::.:..            |...|:|..|:..  |:|.|       :..|:..|    ..|
  Rat  1307 FYFYNKIRKGRHGVHSKSTKEDEDEDIRKEKRKVFTLLLRLQNTPLVLNEVTKIYFKC----PVV 1367

  Fly  1652 RAENLWLAYRRGHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFE----- 1711
            :             ||:|::..|::.|||||||.|||||:|.||:|||:.....|..:.:
  Rat  1368 K-------------AVKNISLVVRKSECFGLLGLNGAGKTTTFKMLTGEETITSGIAFIDGNSVT 1419

  Fly  1712 ------QPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVR 1768
                  :..|.|||||..:...:|..|.:..|.||.|:  :|::::::..|.:..|.|..|..:.
  Rat  1420 KNPRKIRSRIGYCPQSESVLNHMTGRESLIMYARLWGVPEQDINEYVEAFLHSVHLEPIADQIIY 1484

  Fly  1769 NLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIE 1833
            ..|.|::|:|:.|:...|.:..|.:|||::.||||.:.:::.|:..:....:|:::|||.:.|.|
  Rat  1485 TYSAGSKRRLSTAIALMGKSSVVFLDEPSTGMDPVAQHLLWDTVTWVCKTGKAIIITSHRMEECE 1549

  Fly  1834 HLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVT 1867
            .||.|:|::..|:.....:||.::...|..|.:|
  Rat  1550 ALCSRLAIMVKGKFTCLGTPQHVRKRFGQVYTLT 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	35/146 (24%)
		ABC_subfamily_A	859..1073	CDD:213230	74/223 (33%)
		drrA	865..1162	CDD:130256	92/307 (30%)
		ABC2_membrane_3	1230..1601	CDD:289468	86/418 (21%)
		Mem_trans	1436..>1552	CDD:304621	21/117 (18%)
		ABC_subfamily_A	1651..1857	CDD:213230	69/218 (32%)
		drrA	1666..1945	CDD:130256	71/215 (33%)
Abca16	XP_038957107.1	rim_protein	<163..1664	CDD:130324	352/1464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850