DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and Abca9

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	XP_038943368.1	Gene:	Abca9 / 287788	RGDID:	1305931	Length:	1653	Species:	Rattus norvegicus

Alignment Length:	1620	Identity:	383/1620 - (23%)
Similarity:	617/1620 - (38%)	Gaps:	426/1620 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   598 KNKFEVDNMQFYTKQFPYPAF------------------------LNDVFKRGLYLAQ-GVQVAY 637
            |||...:|..|:.|.|  .||                        :..|.|...::|| ||...:
  Rat   193 KNKMVCENSVFWEKGF--VAFQTAINAGIIEVTTNHSVMEELMSVIGSVMKMQPFIAQGGVATDF 255

  Fly   638 LLGLVVFVALSVRERIW-----MRESRNSM--LMRSMGLKAHSELVAWALMSFLELCVIFALISG 695
               .:.|..:|....|:     :.:.|.|:  ||..|||:..:..::|.||....:.|:..|:|.
  Rat   256 ---FIFFCVISFSSFIYYLSVNVTQERQSITTLMAMMGLRESAFWLSWGLMYAGFILVVATLMSL 317

  Fly   696 VLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALL---FFISLCPFIIV 757
            ::.|..::..|.:..:....|.:||.||:..::             .|.||   |...|..|::.
  Rat   318 IVKSTQVVVLTGFMVVFLLFLLYGLSLITLSFL-------------MSVLLKKPFLTGLAVFLLT 369

  Fly   758 LMFDA--------KLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQV-GPARSECA 813
            :.:.:        .|..|..:::......||..|..:||.::..     |...:.: .|..|...
  Rat   370 VFWGSLGFTALYKHLPAFMEWILCFLSPFAFINGMAQLIHLDYD-----VNSNVNLNSPNNSYLI 429

  Fly   814 MA-LLMFLLDLLLYAVIGLAYQR-------------YKKTDNYSFVK------VSRSQLD----- 853
            :| |.|.:||.|||..:.|.:.:             :....:|.|.:      |..:::|
  Rat   430 LATLFMLVLDALLYLALALYFDKILLSKYGHQRSPLFFLKSSYWFQRRGADHVVLENEIDSAPSL 494

  Fly   854 ------------GKLGASLVNVSKLY----GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKL 902
                        ||....:.|:.|.|    |...|:..|..|....|::.|||.:||||:|||..
  Rat   495 NDSLEPVSPEFQGKEAIRIKNLRKEYTGKHGKVEALRGLGFDIYEGQITALLGHSGAGKTTLINT 559

  Fly   903 LTGQIRQSSGKVLL------------AGEHQVGVCWQDNILIPTLTAREHLQLYAQIK-IPPGGS 954
            |:|....::|.:.:            |.....|||.|.||....||.:|:|:|:|:|| |.|
  Rat   560 LSGLSPPTTGSITIYNQTVSETEDSYAVPKLTGVCPQSNIQFGFLTVQENLRLFAKIKGILP--- 621

  Fly   955 GGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKAR 1019
               :|:..||.|.|:.|.....:...:..||||.:|:|...||.:..|.|::||||..|:|..:|
  Rat   622 ---QEVEQEVRQVLRDLEMENIQDTLAQNLSGGQKRKLTFGIAILGDPQVLLLDEPTAGLDPLSR 683

  Fly  1020 KDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRL--- 1081
            ..||.|::..|.||.::|:|.|||||..|:|..|.:.|||:....|...|::.....|.:.|
  Rat   684 HHIWNLLKERRSGRVIVFSTQFMDEADILADRKVFISNGRLRCAGSSLFLKKKWGIGYHLSLHLN 748

  Fly  1082 RCADATGVTFVIQK--------AQQ------LLPQTQV-------------THSGAADYPHSLTI 1119
            ...|...:|.:::|        ||.      :||..:.             ::.|..||..|:|.
  Rat   749 ETCDPESITSLVKKHIPDARLTAQSDEQLVYILPLERTNKFPDLYRDLDRCSNHGIEDYDVSMTT 813

  Fly  1120 ---------NASYAEHLTPGAVEFLELLQSQVTAGSISDVELTTSSSLEQEFEQLNRNGEDAGPR 1175
                     ..|.||....|..       .::.:....|||...      |.|::
  Rat   814 LNEVFLKLEGKSMAEEPDAGVC-------GRLLSDGAKDVESLV------ELERV---------- 855

  Fly  1176 RPASDRSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFE--LCAMWFV 1238
            .|.......|:|.|:...: ..|..:.|.|..|..|.......||..:..:|.|.|  :..::..
  Rat   856 LPLDSSGSSVSGMALWRQQ-LCAVAKVRFLKLKNERRSLMTMLLLFGISFVPQLLEHLVYKVYHK 919

  Fly  1239 SYRLEDDFDTVLPLSRSLYPQTAQFLSHERATSFSEKLYPQLRTSCDHLGECRVFNTSQQSYDWV 1303
            ||.        ..||.|:|     |||..:        .||     |.|....|.|.:..|.|..
  Rat   920 SYS--------WGLSPSMY-----FLSPGQ--------LPQ-----DPLTHLLVINKTGSSIDNF 958

  Fly  1304 LNSWGEYSERRYGGYGL--------NG------SGA-TVWYNNKGYHSMMAW----------LND 1343
            ::|      .|..|..|        ||      :|| ||..:.|.....:|.          |.|
  Rat   959 IHS------LRQQGIALDVDALGTRNGKEEALYNGAVTVLGDEKDLRFSVACNAKRLNCFPVLAD 1017

  Fly  1344 LNSELLRTTMNDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVF--ILLIAFGL-------- 1398
            :.|..|....|.||                       |...|.|.||  .:|..:|.
  Rat  1018 ILSNGLLGIFNSSE-----------------------RIQTDRSTVFEDHMLYEYGFMSNAFFWI 1059

  Fly  1399 -VVASGSVYLVNERVNGEK----LQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFG-- 1456
             |.||.:.|:....::..|    .|....|:....||....:.|..:..|.|::..::..:|.
  Rat  1060 PVAASLTPYIAMGSISDHKKKVLSQLWTSGLYPSAYWCGQALVDIPIYFLILLLMQIMDSVFSSE 1124

  Fly  1457 --MPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIF----SDSSI-----AIVSI--------- 1501
              |.|.   :.|:..|..|:.::.:.:...:|...:|    .:|.|     .||:|
  Rat  1125 EIMSVI---ESLLIQIPCSIGYASSLIFLTYVISFVFRNGRKNSGIWSFFFLIVTIFFIVATDIN 1186

  Fly  1502 --------FCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNY 1558
                    ||..||.|...:|.:||...|.
  Rat  1187 EYGFLQLLFCTLLIPPFTLIGSLLIFSEVS----------------------------------- 1216

  Fly  1559 MVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVER---LLDC 1620
                    ||        :.|.||...:.|:.:.:....::.|:.:.:||.|.:.:.:   .:|.
  Rat  1217 --------YD--------SVDYLGSSESQLVFLALLIPYLHFLLFFFILRCLERYIRKKTLRVDP 1265

  Fly  1621 TYR---------------RELDKLGQLKLVNIQS------------IFKSCVDTGEAVRAENLWL 1658
            .:|               .|.|:..|::.|....            |..||:.....|:.:..:.
  Rat  1266 VFRISPRSCRAFPNPEDPGEEDEDVQMERVRTSGAMTTPQMDEKPVIIASCLRKEYTVKTKRCFS 1330

  Fly  1659 AYRRGHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFEQPG-------IS 1716
            ..:: ..|.||::|.|::||..||||.|||||||...::||...|..||::.:...       :.
  Rat  1331 KTKK-KIATRNISFCVKKGEVLGLLGHNGAGKSTTISMITGDTVPTAGQVFLKGSSGSAALGFLG 1394

  Fly  1717 YCPQSNPLDPLLTTTECIRFYGRLRGIRDLDQF--LDRVLDTYELRPYKDVQVRNLSGGNRRKLT 1779
            ||||.|.|.|.||..|.:..|..::|:|..:..  :.|:::..:|:......|:.||.|.:|||.
  Rat  1395 YCPQENVLWPNLTVKEHLEVYAAVKGLRKKEAIVTITRLVNALKLQDQLKALVKTLSEGVKRKLC 1459

  Fly  1780 VAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLL-ARRAVVLTSHSVSEIEHLCQRVAVLR 1843
            ..::..|....||:|||::.|||..:..::..|..... ..|..:||:|.::|.|.:|.|||::.
  Rat  1460 FVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFTNTERGALLTTHYMAEAEAVCDRVAIMV 1524

  Fly  1844 AGQVIASDSPQRLKSEHGGYYAVTC-FCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRS 1907
            :|::....|.|.|||:.|..|.:.. ...||....|:..:.:..|.|...:.|:..:.:.:.|.
  Rat  1525 SGRLRCIGSIQHLKSKFGKDYLLEMKLKTPALVESLNTEILRLFPQAARQERYSSLMVYKLPVE- 1588

  Fly  1908 PGSLGDAPLLSELFAILCDVCVN--VARFSLSRCRFETVF-----ERILDSSESNGSNGV 1960
                 |...|||.|..|..:..|  :..:|||:...|.||     |:.|...:..||:.|
  Rat  1589 -----DVRPLSEAFFKLERLKENFDLEEYSLSQSTLEQVFLELSKEQELGDFDEEGSSSV 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	35/149 (23%)
		ABC_subfamily_A	859..1073	CDD:213230	82/230 (36%)
		drrA	865..1162	CDD:130256	102/352 (29%)
		ABC2_membrane_3	1230..1601	CDD:289468	84/442 (19%)
		Mem_trans	1436..>1552	CDD:304621	25/145 (17%)
		ABC_subfamily_A	1651..1857	CDD:213230	69/215 (32%)
		drrA	1666..1945	CDD:130256	91/291 (31%)
Abca9	XP_038943368.1	rim_protein	<207..1630	CDD:130324	372/1591 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840