DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and Abca3

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_001034670.1	Gene:	Abca3 / 27410	MGIID:	1351617	Length:	1704	Species:	Mus musculus

Alignment Length:	1547	Identity:	394/1547 - (25%)
Similarity:	664/1547 - (42%)	Gaps:	280/1547 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 ANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALS------VRERI 653
            ||...:.....:...||:||:|.:::|.|.        :.:.|.|.|::.::.:      :|..:
Mouse   227 ANTSAQQLFQKLMVITKRFPFPPYISDPFL--------IAIQYQLPLLLMLSFTYTSLTIIRAVV 283

  Fly   654 WMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALIS-----GVLYSGGILGYTNWFFMMF 713
            ..:|.:....||.|||.:.....||.||.||...::.:.::     .|.....:|..::...::.
Mouse   284 QEKEKKLKEYMRMMGLNSWLHWSAWFLMFFLFFLIVVSFMTLLFCVKVKKDIAVLSNSDPSLVLA 348

  Fly   714 YCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTT 778
            :.|.|.:..|||.:|.:.||:.|||.|.....|:|.:..|:..|......:::.:..|..|....
Mouse   349 FLLCFAISSISFSFMVSTFFSKANIAAAVGGFLYFFTYTPYFFVAPRYNWMTLSQKLLSCLLSNV 413

  Fly   779 AFAKGWGELIRMELQQEGLTVRHLIQ-VGPARSEC-AMALLMFLLDLLLY--------------- 826
            |.|.|...:.:.|.:..|:..|.|:. |....:.| ...|.|.|||..||
Mouse   414 AMAMGAQLIGKFEAKGTGIQWRDLLNPVNVDDNFCFGQVLGMLLLDSALYGLVTWYVEAVFPGQF 478

  Fly   827 --------------------AVIGLAYQRYKKTDNYSFVKVSRSQL------DGKLGASLVNVSK 865
                                .|:|      |:.:.....|..|::.      |...|..:.::||
Mouse   479 GVPQPWHFFLMPSYWCGNPRTVVG------KEEEGSDPEKALRNEYFEAEPEDLVAGIKIKHLSK 537

  Fly   866 LY----GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG-------- 918
            ::    ..|..:.:|:|:....|::.|||.|||||:|.:.||||....:||...:.|
Mouse   538 VFQVGNKDKMGIRDLTLNLYEGQITVLLGHNGAGKTTTMSLLTGLFPPTSGHAYIHGYEISQDMA 602

  Fly   919 --EHQVGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPS 981
              ...:|:|.|.::|...||..|||..|||:|   |.|  :::...||.|.|..|:........|
Mouse   603 QIRKSLGLCPQHDVLFDNLTVAEHLYFYAQLK---GLS--LQKCPEEVKQMLHILSLEDKRDLRS 662

  Fly   982 WQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAK 1046
            ..||||.:|:|.:.||.||...|::||||.:|:||.:|:.||.|:::.:..|.|:..|||||||.
Mouse   663 KFLSGGMKRKLSIGIALIAGSKVLMLDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEAD 727

  Fly  1047 YLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRL----RCADATGVTFVIQKAQQLLPQTQV-T 1106
            .|.|.:.|:..|.:....|...|::...:.|.:.|    .| :..|::   |.....:|...: :
Mouse   728 LLGDRIAILAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHC-NPEGIS---QLVHHHVPNAMLES 788

  Fly  1107 HSGA-------ADYPH--------------SLTINASYAEHLTPGAVEFLELLQSQVTAGSISDV 1150
            |:||       .:..|              .|.| ||:...:|.....||.:.:...|:..|..:
Mouse   789 HAGAELSFILPKESTHRFESLFAKLEKKQKELGI-ASFGASVTTMEEVFLRVGKLVDTSMDIQAI 852

  Fly  1151 ELTTSSSLEQEFEQLNRNGEDAGPRRPASDRS------GVVAGP-----AMITDEPPTA------ 1198
            :|   .:|:.:.|            |.|||.:      ||: .|     |:|.:|....
Mouse   853 QL---PALQYQHE------------RRASDWALDSNLCGVM-DPTNGIGALIEEEEVLVKLNTGL 901

  Fly  1199 ---CKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDTVLPLSRSLYPQT 1260
               |:||..:..|:..:..|.::::...:|:|......|:..:.|..|...|.:|.||.:.|.:|
Mouse   902 ALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCLTLALLAIHYTSEIFDDPLLKLSLNEYGRT 966

  Fly  1261 AQFLSHERATSFSEKLYPQLRTSCD-----------HLGECRVFNTSQQSYDWVLNSWGEYSERR 1314
            ....|....:..:::|...||....           .|.|..||..|.:.        |.::||.
Mouse   967 VVPFSVPGTSRLAQQLSENLRDMLQAERQEPREVLGDLEEFLVFRASVEG--------GGFNERC 1023

  Fly  1315 YGGYGLNGSG----ATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGFAELS 1375
            .........|    .|..:||:.|||....|..::: ||...:...::||...|.|......:::
Mouse  1024 LVATSFKDRGELTVVTALFNNQAYHSPATALAIVDN-LLFKLLCGPQASIEISNYPQPRNTLQVA 1087

  Fly  1376 TSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLV 1440
            ............:...||||...:.::.|:..|:||....|..|.:.||...|:|..||:||.:.
Mouse  1088 KDHFNEGRKGFDIALNLLIAMAFLASTFSILAVSERAVQAKHVQFVSGVHVATFWFSALLWDLIS 1152

  Fly  1441 MVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCAN 1505
            .::..::.|||...|.:..|.....:..::.|.:.:.:|.:|.:::....||.:|.|...:...|
Mouse  1153 FLVPSLLLLVVFQAFNVHAFTRDGHMADLLLLLMLYGWAIIPLMYLMSFFFSAASTAYTRLTIFN 1217

  Fly  1506 LIVPLVTMGIILILGVVGDGPA--WDDWRHALNQAFLIFPIHALGDGFLELCKNY---------- 1558
            ::..:.|..::.|:.:    ||  .::....|:..||:.|.|.||.......:||
Mouse  1218 ILSGIATFIMVTIMRI----PAVKLEELSRTLDHVFLVLPNHCLGMAVSNFYENYETRRYCTSSE 1278

  Fly  1559 MVALVFRRYDI---DSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERLLDC 1620
            :.|...::|:|   :|: :..::..:|:..|::...|...|.:..|||.:||.||     |...|
Mouse  1279 LAAHYCKKYNIQYQESF-YAWSTPGVGKFVTSMAASGGIYLTLLFLIETNLLWRL-----RTFIC 1337

  Fly  1621 TYRR----------------ELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGHYAVRN 1669
            .:||                :.|...:...:.:.|: .|.:||...:...:.....|....||..
Mouse  1338 AFRRRWTLAELQNRTSVLPEDQDVAEERSRILVPSL-DSMLDTPLIINELSKVYDQRAPLLAVDR 1401

  Fly  1670 VNFSVQRGECFGLLGKNGAGKSTIFKLLTGQ--------------LQPDVGQIYFEQPGISYCPQ 1720
            ::.:||:||||||||.|||||:|.||:|||:              :..|:|::   :..:.||||
Mouse  1402 ISLAVQKGECFGLLGFNGAGKTTTFKMLTGEETITSGDAFVGGYSISSDIGKV---RQRMGYCPQ 1463

  Fly  1721 SNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVT 1783
            .:.|...:|..|.:..|.|||||  |.::..::..|....|.|:.:..|:..||||:|||:..:.
Mouse  1464 FDALLDHMTGREMLVMYARLRGIPERLINACVENTLRGLLLEPHANKLVKTYSGGNKRKLSTGIA 1528

  Fly  1784 CCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVI 1848
            ..|....:.:|||::.||||.|.:::.|:.:...:.:|:|:||||:.|.|.||.|:|::..||..
Mouse  1529 LIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIVITSHSMEECEALCTRLAIMVQGQFK 1593

  Fly  1849 ASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQRL-----------PGA------RDLQHYA 1896
            ...|||.|||:.|..|::       |..:.|......|           ||:      :|:.||
Mouse  1594 CLGSPQHLKSKFGSGYSL-------QAKVRSEGKQDALEEFKAFVDLTFPGSILEDEHQDMVHY- 1650

  Fly  1897 HSLRFLVRVRSPG-SLGDAPLLSELFAIL--CDVCVNVARFSLSRCRFETVF 1945
                     ..|| .|..|    ::|.||  ......|..:|:|:...|.||
Mouse  1651 ---------HLPGCDLSWA----KVFGILEKAKEKYGVDDYSVSQISLEQVF 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	36/149 (24%)
		ABC_subfamily_A	859..1073	CDD:213230	80/227 (35%)
		drrA	865..1162	CDD:130256	100/336 (30%)
		ABC2_membrane_3	1230..1601	CDD:289468	87/400 (22%)
		Mem_trans	1436..>1552	CDD:304621	26/117 (22%)
		ABC_subfamily_A	1651..1857	CDD:213230	78/221 (35%)
		drrA	1666..1945	CDD:130256	101/314 (32%)
Abca3	NP_001034670.1	rim_protein	1..>43	CDD:130324
Abca3	NP_001034670.1	rim_protein	<206..1699	CDD:130324	394/1547 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750