DRSC/TRiP Functional Genomics Resources

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Protein Alignment ldd and ABCA12

DIOPT Version :10

Sequence 1:NP_001285513.1 Gene:ldd / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens


Alignment Length:2248 Identity:525/2248 - (23%)
Similarity:879/2248 - (39%) Gaps:620/2248 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 EAPLHSVIDVVNAFVTDER------LHKAVVELAEKANFVSAITTLITSDRFDI-IRSNISEIIS 156
            ||.||    |.|:....|:      :.|.|.||.|.....:.::.........| |..|.:||||
Human   537 EAMLH----VNNSADASEKPGQLLEMFKNVEELKEDLRRTTGMSNRTIDKLLAIPIPDNRAEIIS 597

  Fly   157 LV------------PEIERRMN---------------------------YSFDIKHLFSNR---- 178
            .|            |::|..|.                           |:|..|..|..:    
Human   598 QVFWLHSCDTNITTPKLEDAMKEFCNLSLSERSRQSYLIGLTLLHYLNIYNFTYKVFFPRKDQKP 662

  Fly   179 -----ETFVKLGVLL----CG-HP------------FPNTDTIPLVNEILESE-------DFSQA 214
                 |.|::|..:|    .| ||            .|.  ::||...:..|.       .||..
Human   663 VEKMMELFIRLKEILNQMASGTHPLLDKMRSLKQMHLPR--SVPLTQAMYRSNRMNTPQGSFSTI 725

  Fly   215 NDA---------EIDAMPTRRRRRYEDLPTDWRP----------------------------TKY 242
            :.|         .:.||          ||:..||                            |.:
Human   726 SQALCSQGITTEYLTAM----------LPSSQRPKGNHTKDFLTYKLTKEQIASKYGIPINSTPF 780

  Fly   243 CKRLYRDVTSTNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEELDRLKQLSR----A 303
            |..||:|:.:...|.:.|..:||::.|||||.|.|.:|:::::.||.:..:|..|::.|:    .
Human   781 CFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDK 845

  Fly   304 AATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDIG-----------EIERVFEYIRTNQ 357
            :...:...|   ...:|...|....::|.|:..|  .|.:|           |::.:...:..|.
Human   846 SPLFMNSFH---LLNQAIPMLQNTLRNPFVQVFV--KFSVGLDAVELLKQIDELDILRLKLENNI 905

  Fly   358 LIYDILTTVADL----MDCVSADRFEAVESVEELH---KRAYELNQ-----------NKLFLAAL 404
            .|.|.|.|::.|    ..||..||.:|.::::|:.   ||.|:.|:           |:.:....
Human   906 DIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGY 970

  Fly   405 NLEDVGLKQA-SYRLHMDTDNTQPTFENRNRFWFPGPADSMVIDLKYHRGFVQLKQMVDLGIIKS 468
            :..:|.|... .|.:.|.....|.|...|.:.|.|||.:|...:..|.|.|:.|:..::..||:.
Human   971 DSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIEL 1035

  Fly   469 KREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHE 533
                          ::||:                                              
Human  1036 --------------QTGRN---------------------------------------------- 1040

  Fly   534 ATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKK 598
                         ::|:.|..:                                           
Human  1041 -------------SQEIAVQVQ------------------------------------------- 1049

  Fly   599 NKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSML 663
                         ..|||.|:.|.|...  ::..:.:..::..|||:|..|::.::.::.|....
Human  1050 -------------AIPYPCFMKDNFLTS--VSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEY 1099

  Fly   664 MRSMGLKAHSELVAWALMS--FLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFC 726
            |:.||:.:.|...||.:.|  ||.:.::..:|  :|..|.||..||.|.:..|...:...:|:..
Human  1100 MKMMGVNSCSHFFAWLIESVGFLLVTIVILII--ILKFGNILPKTNGFILFLYFSDYSFSVIAMS 1162

  Fly   727 YMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRME 791
            |:.:.|||:.||.|:..:|::.|:..|||:::..:.:||......:.|...|||:.....:.|.|
Human  1163 YLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYE 1227

  Fly   792 LQQEGLTVRHLIQVGPARSE-------CAMALLMFLLDLLLYAVI-------------------- 829
            .|..||...:: ...|.:.:       |.    :.|.|..:|.:|                    
Human  1228 EQGIGLQWENM-YTSPVQDDTTSFGWLCC----LILADSFIYFLIAWYVRNVFPGTYGMAAPWYF 1287

  Fly   830 -----------GLAYQRYKKTDNYSFVKV-------SRSQL---------------DGKLGASLV 861
                       |.|..:.:|::...|..:       |.|:.               |..:|.:|.
Human  1288 PILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALH 1352

  Fly   862 NVSKLYGSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGE------H 920
            .|:|:||||.||.||:|:|....::.|||.|||||:|.|.:|||....|:|.:.:.|:      |
Human  1353 GVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLH 1417

  Fly   921 QV----GVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPS 981
            .|    |||.|.::|...||.:|||.||..||:|....   :::..||.:||:......|.....
Human  1418 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTK---KQLHEEVKRTLKDTGLYSHRHKRV 1479

  Fly   982 WQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAK 1046
            ..||||.:|:|.::||.|....|||||||..|||..:|:.||.:|.:.:..|.:|.:||.:|||:
Human  1480 GTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAE 1544

  Fly  1047 YLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQL------------ 1099
            .|||.:..:..|.:          |.|.|.:.::....|...:|...:|:..|            
Human  1545 VLSDRIAFLEQGGL----------RCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVT 1599

  Fly  1100 ------LPQTQVTH--SGAADY---PHSLTINASYAEHLTPGAVEFLELLQS--------QVTAG 1145
                  ||:..:..  .|...|   |.|..::.:|           |.||::        .:...
Human  1600 AMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAY-----------LSLLRALDNGMGDLNIGCY 1653

  Fly  1146 SISD-------VELTTSS------SLEQEFEQLNRNGEDAGPRRP---------ASDRSGVVAGP 1188
            .|||       :.||..|      |||...::...|....|...|         .:||...:...
Human  1654 GISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTR 1718

  Fly  1189 AMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDTVLPLS 1253
            ....|......|:...::.||..|..||::.|:..::||.:|...||...:.|...:....:.:|
Human  1719 GERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQIS 1783

  Fly  1254 RSLY---PQTAQFLSHERATSFSEKL------YPQLRTSC------------------------- 1284
            .|||   .|||.:.::..:|   |.|      :|.:...|                         
Human  1784 PSLYGTSEQTAFYANYHPST---EALVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPIT 1845

  Fly  1285 --------DHLGECRVFN-----------------TSQQSYDWVLNSWGEYSERRYGG--YGL-- 1320
                    :::.||..||                 |.|:..::::::..|:.::||||  :||  
Human  1846 NFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPL 1910

  Fly  1321 -------------NGSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESS---ILTLNEPWKL 1369
                         |.:.|.|||:.:||||:.|:||.||:.|||..|:..:::   |:..:.|:. 
Human  1911 TKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYP- 1974

  Fly  1370 GFAELSTSSILRQAGDGSMVFIL-----LIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTY 1429
            |..:...::|      .|::.||     |:.:.:..||...|:|.|.....|..|.:.|:....|
Human  1975 GVQDQEQATI------SSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCY 2033

  Fly  1430 WLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDS 1494
            |:...::|.:..::.:...:.:|.:|.:|.|.....|..:..|.|.|.:|....:::...:|.::
Human  2034 WVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHET 2098

  Fly  1495 SIAIVSIFCANL---IVPLVTMGIILILG-VVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELC 1555
            .:|.::..|.||   |..:|::.::..|. ...:.|..:.....|.:.|||||....|.|.:||.
Human  2099 GMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELS 2163

  Fly  1556 KNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERLLDC 1620
            :...|....:.|.::........:.||..|.||:..|.....:.:||...|:::|     ||   
Human  2164 QQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKL-----RL--- 2220

  Fly  1621 TYRRELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWL-----------------AYRRGH---Y 1665
             :.|:.:          .|..:..:|..|.||||.|.:                 .|:..|   .
Human  2221 -FFRKFN----------SSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQLIHKKII 2274

  Fly  1666 AVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFEQPG------------ISYC 1718
            ||.|::..:..||||||||.|||||:||||:|||.:.|..|.|......            :.||
Human  2275 AVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYC 2339

  Fly  1719 PQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVA 1781
            ||.:.||.|:|..|.:.||.|:.||  :|:.:.:.::|....|.|:||......|.|.:|||:.|
Human  2340 PQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTA 2404

  Fly  1782 VTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQ 1846
            :...|....:|:|||:|.|||.::..::..|.:.:..:.:|:|||||:.|.|.||.|:|::..|:
Human  2405 LALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGK 2469

  Fly  1847 VIASDSPQRLKSEHGGYYAVTCFC--GPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPG 1909
            .....|.|.:||..|..:.|....  .......|::.:....|.......:...|.:.|.|.:.|
Human  2470 FQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGG 2534

  Fly  1910 SLGDAPLLSELFAIL--CDVCVNVARFSLSRCRFETVF 1945
                   ::.:|.:|  ....:|:..|.:|:...|.||
Human  2535 -------VANIFDLLETNKTALNITNFLVSQTTLEEVF 2565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lddNP_001285513.1 rim_protein 179..1867 CDD:130324 483/2029 (24%)
ABCA12XP_011509253.1 rim_protein 7..>86 CDD:130324
rim_protein 752..2579 CDD:130324 478/2017 (24%)
Blue background indicates that the domain is not in the aligned region.

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