DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34120 and ABCA4

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:NP_000341.2 Gene:ABCA4 / 24 HGNCID:34 Length:2273 Species:Homo sapiens


Alignment Length:2496 Identity:562/2496 - (22%)
Similarity:939/2496 - (37%) Gaps:752/2496 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 REVRELLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLK---YGSEELEACQYPTRLLPTKNQ 69
            |:::.||.|:..:|.|||...::.|.||:.:|::|..:|..   |...|   |.:|.:.:|:.. 
Human     5 RQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHE---CHFPNKAMPSAG- 65

  Fly    70 VVPAAFSYICSIENRC-QPAHPYE----------------------------EYSH----WKEAP 101
            ::|......|::.|.| |...|.|                            |..|    |.|..
Human    66 MLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQHLGRIWTELH 130

  Fly   102 LHS--------------------------------------------VIDVVNAFVTDERLHKAV 122
            :.|                                            |..::|:.|..|:....|
Human   131 ILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQVRPEQFAHGV 195

  Fly   123 VELAEKANFVSAITTLITSDRF----------------------------DIIRSNIS--EIISL 157
            .:||.|.  ::....|:  :||                            |.:.:|:.  ::..:
Human   196 PDLALKD--IACSEALL--ERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLYANVDFFKLFRV 256

  Fly   158 VPEIERRMNYSFDIKH------------------------------LFSN--RETFVKL-GV--- 186
            :|.:....:...:::.                              |..|  .|||.|| |:   
Human   257 LPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLMQNGGPETFTKLMGILSD 321

  Fly   187 LLCGHPFPNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVT 251
            ||||:|......:...|..   ||.:......||:  ||:...|.   .|.|.|.:|..|.:.:.
Human   322 LLCGYPEGGGSRVLSFNWY---EDNNYKAFLGIDS--TRKDPIYS---YDRRTTSFCNALIQSLE 378

  Fly   252 STNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEELDRLKQLSRAAATILTKLHTNAT 316
            |....|:.|...||::.|:|||||.:.....::|.:|::||||:.:::|.:|             
Human   379 SNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKA------------- 430

  Fly   317 FQEA-------FDNLLKLAKSPLVKSLVGD----DF---DIGE----IERVFEYI----RTNQL- 358
            ::|.       |||..::   .:::..:|:    ||   .:||    .|.:..::    |.:|. 
Human   431 WEEVGPQIWYFFDNSTQM---NMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQAD 492

  Fly   359 ---------IYDI----LTTVADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLAALNLEDVG 410
                     |::|    |..|...::|:..|:||:.....:|.:||..|.:..:|.|.:...|:.
Human   493 DMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMY 557

  Fly   411 LKQAS------YRLHMDTDNTQPTFENRNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKS 468
            ...:|      |::.||.|..:.|.:.::|:|..||....|.|.:| ..||..|:.||:.||.:|
Human   558 PWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRS 622

  Fly   469 KREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHE 533
                                       ||:.:.|                               
Human   623 ---------------------------QVQAEAP------------------------------- 629

  Fly   534 ATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKK 598
                                                                             
Human   630 ----------------------------------------------------------------- 629

  Fly   599 NKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSML 663
                   :..|.:|.|||.|::|.|.  :.|.:...:..:|..:..|:::|:..:..:|.|....
Human   630 -------VGIYLQQMPYPCFVDDSFM--IILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKET 685

  Fly   664 MRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYM 728
            :::.|:........|.|.||..:.:...|::..:..|.||.|::.|.:..:.|:|....|..|::
Human   686 LKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFL 750

  Fly   729 CTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQ 793
            .:.||:.|::.|..|.:::|....|.|:...:..:::......|.|....||..|...|:|.|.|
Human   751 LSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQ 815

  Fly   794 QEGLTVRHLIQVGPARSE-----CAMALLMFLLDLLLYAVIG-------------------LAYQ 834
            ..||   ....:|.:.:|     ..:::.|.|||..:|.::.                   |..:
Human   816 GLGL---QWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQE 877

  Fly   835 RY---------------KKTD---------------NYSFVKVSRSQLDGKLGASLVNVSKLYGS 869
            .|               :||:               :.||.:  |.......|..:.|:.|:: .
Human   878 SYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFE--REHPGWVPGVCVKNLVKIF-E 939

  Fly   870 KC---AVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG----------EHQ 921
            .|   ||..|::.|..||::..||.|||||:|.:.:|||.:..:||.||:.|          ...
Human   940 PCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQS 1004

  Fly   922 VGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSG 986
            :|:|.|.|||...||..||:..|||:|   |.|  .||.:.|:...|:........:..:..|||
Human  1005 LGMCPQHNILFHHLTVAEHMLFYAQLK---GKS--QEEAQLEMEAMLEDTGLHHKRNEEAQDLSG 1064

  Fly   987 GYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDS 1051
            |.:|:|.|||||:....|||||||.:|||..:|:.||.|:.:.|.||.:|.:||.||||..|.|.
Human  1065 GMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDR 1129

  Fly  1052 LVIMRNGRIIA--------------------------QHSRDSLQRLCT-SNYSIRLRC------ 1083
            :.|:..||:..                          |..|...:..|: |:......|      
Human  1130 IAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDD 1194

  Fly  1084 ----------------------ADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTIN------ 1120
                                  .:|..|..:.|:...|||.....|...|.....|...      
Human  1195 LTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGL 1259

  Fly  1121 ASYAEHLTPGAVEFLELLQSQVTAGSISDVELTTSSSLEQEFEQLNRNGEDAGPRRPA--SDRSG 1183
            :|:....||....||::.:.       ||.....:...:|:.|.:|......|||..|  :.:..
Human  1260 SSFGISDTPLEEIFLKVTED-------SDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDS 1317

  Fly  1184 VVAGP----AMITDEPP---------------TACKQFRLLMGKRLRHLSRNYRLLLYVLLLPAL 1229
            .|..|    |....:||               ...:..:.|:.||.:|..|:::..|..::|||.
Human  1318 NVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPAT 1382

  Fly  1230 FELCAM----------------------------------------------------------- 1235
            |...|:                                                           
Human  1383 FVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKE 1447

  Fly  1236 -WFVSYRLEDDFDTVLPLSRSLYPQTAQFLSHERAT----------SFSEKLY------------ 1277
             |...|...:......|   |:.|...|....::.|          |..|||.            
Human  1448 GWLPEYPCGNSTPWKTP---SVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGL 1509

  Fly  1278 -PQLRT--SCDHLGECRVFNTSQ---QSYDWVLNS------WGEYSERRYGGYGLNG-------- 1322
             |..||  |.:.|.:....|.|.   ::|..::.|      |  .:|:||||..:.|        
Human  1510 PPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFW--VNEQRYGGISIGGKLPVVPIT 1572

  Fly  1323 -----------------SGA-----------------------TVWYNNKGYHSMMAWLNDLNSE 1347
                             ||.                       .||:||||:|:::::||..::.
Human  1573 GEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNA 1637

  Fly  1348 LLRTTM----NDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLV 1408
            :||.::    :..|..|..:::|..|...:||..::|..:.|..:...::.:...|.||..:||:
Human  1638 ILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI 1702

  Fly  1409 NERVNGEKLQQRLCGVSAVTYWLVALVWD---YLVMVLGLIVCLVVILMFGMPVFVDRQQLVGII 1470
            .||||..|..|.:.|||..|||:...:||   |.|.. ||:|  .:.:.|....:...:.|..::
Human  1703 QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSA-GLVV--GIFIGFQKKAYTSPENLPALV 1764

  Fly  1471 GLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHAL 1535
            .|.|.:.:|.:|.::.|..:|...|.|.|::.||||.:.:.:..|..||.:..:......:...|
Human  1765 ALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVL 1829

  Fly  1536 NQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINV 1600
            .:..::||...||.|.::|..:..|..|:.|:..:...:|...||:|::..|:::.||...::.:
Human  1830 RKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTL 1894

  Fly  1601 LIEWHLLRRLW---QRVERLLDCTYRRELDKLGQLKLVNIQSIFKSCVDTG----EAVRAENLWL 1658
            |::.|.....|   ...|.::|     |.|.:.:.:    |.|.     ||    :.:|...|..
Human  1895 LVQRHFFLSQWIAEPTKEPIVD-----EDDDVAEER----QRII-----TGGNKTDILRLHELTK 1945

  Fly  1659 AY-RRGHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTG--------------QLQPDVGQI 1708
            .| .....||..:...|:.||||||||.|||||:|.||:|||              .:..::.::
Human  1946 IYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEV 2010

  Fly  1709 YFEQPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLS 1771
            :   ..:.||||.:.:|.|||..|.:..|.||||:  .::::..:..:.:..|..|.|......|
Human  2011 H---QNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYS 2072

  Fly  1772 GGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLC 1836
            |||:|||:.|:...||.|.||:||||:.|||..|.|::..|..::...|||||||||:.|.|.||
Human  2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALC 2137

  Fly  1837 QRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQ-------RLPGARDLQH 1894
            .|:|::..|......:.|.|||:.|..|.||......:..:|. .||.       ..||:...:.
Human  2138 TRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLP-DLNPVEQFFQGNFPGSVQRER 2201

  Fly  1895 YAHSLRFLVRVRSPGSLGDAPLLSELFAILCD--VCVNVARFSLSRCRFETVFERILDSSESNGS 1957
            :.:.|:|.|...|         |:.:|.:|..  ..:.:..:|:::...:.||...         
Human  2202 HYNMLQFQVSSSS---------LARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNF--------- 2248

  Fly  1958 NGVHKDQQQQVAKNDLPSKSPAVGGT 1983
                  .:||...:|||....|.|.:
Human  2249 ------AKQQTESHDLPLHPRAAGAS 2268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 31/138 (22%)
ABC_subfamily_A 859..1073 CDD:213230 87/252 (35%)
drrA 865..1162 CDD:130256 106/370 (29%)
ABC2_membrane_3 1230..1601 CDD:289468 109/519 (21%)
Mem_trans 1436..>1552 CDD:304621 31/118 (26%)
ABC_subfamily_A 1651..1857 CDD:213230 82/222 (37%)
drrA 1666..1945 CDD:130256 99/303 (33%)
ABCA4NP_000341.2 rim_protein 1..2272 CDD:130324 562/2496 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..911 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1345 12/60 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148357
Domainoid 1 1.000 134 1.000 Domainoid score I5010
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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