Protein Alignment ldd and ABCA4

DIOPT Version :10

• Sequence 1: NP_001285513.1
• Gene: ldd / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: NP_000341.2
• Gene: ABCA4 / 24
• HGNCID: 34
• Length: 2273
• Species: Homo sapiens
• Alignment Length: 2496
• Identity: 562/2496 - (22%)
• Similarity: 939/2496 - (37%)
• Gaps: 752/2496 - (30%)

  Fly     8 REVRELLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLK---YGSEELEACQYPTRLLPTKNQ 69
            |:::.||.|:..:|.|||...::.|.||:.:|::|..:|..   |...|   |.:|.:.:|:..
Human     5 RQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHE---CHFPNKAMPSAG- 65

  Fly    70 VVPAAFSYICSIENRC-QPAHPYE----------------------------EYSH----WKEAP 101
            ::|......|::.|.| |...|.|                            |..|    |.|..
Human    66 MLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQHLGRIWTELH 130

  Fly   102 LHS--------------------------------------------VIDVVNAFVTDERLHKAV 122
            :.|                                            |..::|:.|..|:....|
Human   131 ILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQVRPEQFAHGV 195

  Fly   123 VELAEKANFVSAITTLITSDRF----------------------------DIIRSNIS--EIISL 157
            .:||.|.  ::....|:  :||                            |.:.:|:.  ::..:
Human   196 PDLALKD--IACSEALL--ERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLYANVDFFKLFRV 256

  Fly   158 VPEIERRMNYSFDIKH------------------------------LFSN--RETFVKL-GV--- 186
            :|.:....:...:::.                              |..|  .|||.|| |:
Human   257 LPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLMQNGGPETFTKLMGILSD 321

  Fly   187 LLCGHPFPNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVT 251
            ||||:|......:...|..   ||.:......||:  ||:...|.   .|.|.|.:|..|.:.:.
Human   322 LLCGYPEGGGSRVLSFNWY---EDNNYKAFLGIDS--TRKDPIYS---YDRRTTSFCNALIQSLE 378

  Fly   252 STNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEELDRLKQLSRAAATILTKLHTNAT 316
            |....|:.|...||::.|:|||||.:.....::|.:|::||||:.:::|.:|
Human   379 SNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKA------------- 430

  Fly   317 FQEA-------FDNLLKLAKSPLVKSLVGD----DF---DIGE----IERVFEYI----RTNQL- 358
            ::|.       |||..::   .:::..:|:    ||   .:||    .|.:..::    |.:|.
Human   431 WEEVGPQIWYFFDNSTQM---NMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQAD 492

  Fly   359 ---------IYDI----LTTVADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLAALNLEDVG 410
                     |::|    |..|...::|:..|:||:.....:|.:||..|.:..:|.|.:...|:.
Human   493 DMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMY 557

  Fly   411 LKQAS------YRLHMDTDNTQPTFENRNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKS 468
            ...:|      |::.||.|..:.|.:.::|:|..||....|.|.:| ..||..|:.||:.||.:|
Human   558 PWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRS 622

  Fly   469 KREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHE 533
                                       ||:.:.|
Human   623 ---------------------------QVQAEAP------------------------------- 629

  Fly   534 ATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKK 598
                                                                             
Human   630 ----------------------------------------------------------------- 629

  Fly   599 NKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSML 663
                   :..|.:|.|||.|::|.|.  :.|.:...:..:|..:..|:::|:..:..:|.|....
Human   630 -------VGIYLQQMPYPCFVDDSFM--IILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKET 685

  Fly   664 MRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYM 728
            :::.|:........|.|.||..:.:...|::..:..|.||.|::.|.:..:.|:|....|..|::
Human   686 LKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFL 750

  Fly   729 CTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQ 793
            .:.||:.|::.|..|.:::|....|.|:...:..:::......|.|....||..|...|:|.|.|
Human   751 LSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQ 815

  Fly   794 QEGLTVRHLIQVGPARSE-----CAMALLMFLLDLLLYAVIG-------------------LAYQ 834
            ..||   ....:|.:.:|     ..:::.|.|||..:|.::.                   |..:
Human   816 GLGL---QWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQE 877

  Fly   835 RY---------------KKTD---------------NYSFVKVSRSQLDGKLGASLVNVSKLYGS 869
            .|               :||:               :.||.:  |.......|..:.|:.|:: .
Human   878 SYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFE--REHPGWVPGVCVKNLVKIF-E 939

  Fly   870 KC---AVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG----------EHQ 921
            .|   ||..|::.|..||::..||.|||||:|.:.:|||.:..:||.||:.|          ...
Human   940 PCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQS 1004

  Fly   922 VGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSG 986
            :|:|.|.|||...||..||:..|||:|   |.|  .||.:.|:...|:........:..:..|||
Human  1005 LGMCPQHNILFHHLTVAEHMLFYAQLK---GKS--QEEAQLEMEAMLEDTGLHHKRNEEAQDLSG 1064

  Fly   987 GYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDS 1051
            |.:|:|.|||||:....|||||||.:|||..:|:.||.|:.:.|.||.:|.:||.||||..|.|.
Human  1065 GMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDR 1129

  Fly  1052 LVIMRNGRIIA--------------------------QHSRDSLQRLCT-SNYSIRLRC------ 1083
            :.|:..||:..                          |..|...:..|: |:......|
Human  1130 IAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDD 1194

  Fly  1084 ----------------------ADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTIN------ 1120
                                  .:|..|..:.|:...|||.....|...|.....|...
Human  1195 LTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGL 1259

  Fly  1121 ASYAEHLTPGAVEFLELLQSQVTAGSISDVELTTSSSLEQEFEQLNRNGEDAGPRRPA--SDRSG 1183
            :|:....||....||::.:.       ||.....:...:|:.|.:|......|||..|  :.:..
Human  1260 SSFGISDTPLEEIFLKVTED-------SDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDS 1317

  Fly  1184 VVAGP----AMITDEPP---------------TACKQFRLLMGKRLRHLSRNYRLLLYVLLLPAL 1229
            .|..|    |....:||               ...:..:.|:.||.:|..|:::..|..::|||.
Human  1318 NVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPAT 1382

  Fly  1230 FELCAM----------------------------------------------------------- 1235
            |...|:
Human  1383 FVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKE 1447

  Fly  1236 -WFVSYRLEDDFDTVLPLSRSLYPQTAQFLSHERAT----------SFSEKLY------------ 1277
             |...|...:......|   |:.|...|....::.|          |..|||.
Human  1448 GWLPEYPCGNSTPWKTP---SVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGL 1509

  Fly  1278 -PQLRT--SCDHLGECRVFNTSQ---QSYDWVLNS------WGEYSERRYGGYGLNG-------- 1322
             |..||  |.:.|.:....|.|.   ::|..::.|      |  .:|:||||..:.|
Human  1510 PPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFW--VNEQRYGGISIGGKLPVVPIT 1572

  Fly  1323 -----------------SGA-----------------------TVWYNNKGYHSMMAWLNDLNSE 1347
                             ||.                       .||:||||:|:::::||..::.
Human  1573 GEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNA 1637

  Fly  1348 LLRTTM----NDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLV 1408
            :||.::    :..|..|..:::|..|...:||..::|..:.|..:...::.:...|.||..:||:
Human  1638 ILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI 1702

  Fly  1409 NERVNGEKLQQRLCGVSAVTYWLVALVWD---YLVMVLGLIVCLVVILMFGMPVFVDRQQLVGII 1470
            .||||..|..|.:.|||..|||:...:||   |.|.. ||:|  .:.:.|....:...:.|..::
Human  1703 QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSA-GLVV--GIFIGFQKKAYTSPENLPALV 1764

  Fly  1471 GLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHAL 1535
            .|.|.:.:|.:|.::.|..:|...|.|.|::.||||.:.:.:..|..||.:..:......:...|
Human  1765 ALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVL 1829

  Fly  1536 NQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINV 1600
            .:..::||...||.|.::|..:..|..|:.|:..:...:|...||:|::..|:::.||...::.:
Human  1830 RKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTL 1894

  Fly  1601 LIEWHLLRRLW---QRVERLLDCTYRRELDKLGQLKLVNIQSIFKSCVDTG----EAVRAENLWL 1658
            |::.|.....|   ...|.::|     |.|.:.:.:    |.|.     ||    :.:|...|..
Human  1895 LVQRHFFLSQWIAEPTKEPIVD-----EDDDVAEER----QRII-----TGGNKTDILRLHELTK 1945

  Fly  1659 AY-RRGHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTG--------------QLQPDVGQI 1708
            .| .....||..:...|:.||||||||.|||||:|.||:|||              .:..::.::
Human  1946 IYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEV 2010

  Fly  1709 YFEQPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLS 1771
            :   ..:.||||.:.:|.|||..|.:..|.||||:  .::::..:..:.:..|..|.|......|
Human  2011 H---QNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYS 2072

  Fly  1772 GGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLC 1836
            |||:|||:.|:...||.|.||:||||:.|||..|.|::..|..::...|||||||||:.|.|.||
Human  2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALC 2137

  Fly  1837 QRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQ-------RLPGARDLQH 1894
            .|:|::..|......:.|.|||:.|..|.||......:..:|. .||.       ..||:...:.
Human  2138 TRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLP-DLNPVEQFFQGNFPGSVQRER 2201

  Fly  1895 YAHSLRFLVRVRSPGSLGDAPLLSELFAILCD--VCVNVARFSLSRCRFETVFERILDSSESNGS 1957
            :.:.|:|.|...|         |:.:|.:|..  ..:.:..:|:::...:.||...
Human  2202 HYNMLQFQVSSSS---------LARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNF--------- 2248

  Fly  1958 NGVHKDQQQQVAKNDLPSKSPAVGGT 1983
                  .:||...:|||....|.|.:
Human  2249 ------AKQQTESHDLPLHPRAAGAS 2268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ldd	NP_001285513.1	rim_protein	179..1867	CDD:130324	491/2056 (24%)
ABCA4	NP_000341.2	rim_protein	1..2272	CDD:130324	562/2496 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..911		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1284..1345		12/60 (20%)
		Essential for ATP binding and ATPase activity. /evidence=ECO:0000269|PubMed:31481235	2244..2249		2/19 (11%)