DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34120 and ABCA5

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens


Alignment Length:1529 Identity:352/1529 - (23%)
Similarity:624/1529 - (40%) Gaps:308/1529 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   621 DVFKRGLYLAQGVQVAYLLGLVV-------FVALSVRERIWMRESRNSMLMRSMGLKAHSELVAW 678
            |.|.||:         .|:.||:       |:|:.:   :..:|.:....::.|||...:..::|
Human   214 DTFPRGV---------ILIYLVIAFSPFGYFLAIHI---VAEKEKKIKEFLKIMGLHDTAFWLSW 266

  Fly   679 ALMSFLELCVIFALISGVLYSGGIL---GYTNWFFMMFYCLSFGLCLISFCYMCTNFF-NSANIG 739
            .|: :..|..:.:|:..|:.:..:|   ..:...|::|:.  :||..:.|..|.|..| .|.::|
Human   267 VLL-YTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFL--YGLSSVFFALMLTPLFKKSKHVG 328

  Fly   740 AVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFT------TAFAKGWGELIRMELQQEGLT 798
            .|.    ||:::....|.||    :.:.|||...|.:.      ..|..|..:::.:|...||.:
Human   329 IVE----FFVTVAFGFIGLM----IILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGAS 385

  Fly   799 VRHLIQVGPARSECAMALLMFLLDLLLYAVIGL---------------------------AYQRY 836
            ..:| ..||  ....:.::|..|:.:.|.::.:                           :.:.|
Human   386 FSNL-TAGP--YPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNY 447

  Fly   837 KK------TDNYSFVKVSR---SQLDGKLGASLVNVSKLYGSKC----AVSNLSLDFARNQVSCL 888
            ::      ..|.||.::..   |:..||....:..:.|.|..|.    |:.|||.|....|::.|
Human   448 EELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITAL 512

  Fly   889 LGRNGAGKSTLIKLLTGQIRQSSGKVLLAGEH------------QVGVCWQDNILIPTLTAREHL 941
            ||.:|.|||||:.:|.|....|.|...:.|..            .:|:|.|.:|....||..|:|
Human   513 LGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENL 577

  Fly   942 QLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVI 1006
            .:.|.||..|..:     |..||.:.|..|:....:...:.:||||.:|:|.:.||.:.:|.:::
Human   578 SILASIKGIPANN-----IIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILL 637

  Fly  1007 LDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQR 1071
            ||||..|:|..:|..:|.|::..:..|..:|:|||||||..|:|...::..|.:....|...|: 
Human   638 LDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLK- 701

  Fly  1072 LCTSNYSIRLR--------CADAT----------GVTFVIQKAQQL---LP-QTQVTHSG---AA 1111
               |.:.|..|        ||..:          |.|.:.|..|||   || :.....||   |.
Human   702 ---SKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSAL 763

  Fly  1112 DYPHSLTINASYAEHLTPGAVEFLEL-LQSQVTAGSISDVELTTSSSLEQEFEQLNRNGEDAGPR 1175
            |...:|.: .||...:|.....||:| :::::..   :|..:.|...||:|.:..:.:..:....
Human   764 DSHSNLGV-ISYGVSMTTLEDVFLKLEVEAEIDQ---ADYSVFTQQPLEEEMDSKSFDEMEQSLL 824

  Fly  1176 RPASDRSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSY 1240
            ..:..::.:|:..::...:..|..| |.....||.....|:..|||.:.....:|    |:.|.:
Human   825 ILSETKAALVSTMSLWKQQMYTIAK-FHFFTLKRESKSVRSVLLLLLIFFTVQIF----MFLVHH 884

  Fly  1241 RLEDDFDTVLPLSRSLYPQTAQFLS-----HERATSFSEKLYPQLRTSCD-HLGECRVFNTSQQS 1299
            ..:   :.|:|:  .|.|. ..||.     |:..||.      .|:.|.| .:.:...|.|||..
Human   885 SFK---NAVVPI--KLVPD-LYFLKPGDKPHKYKTSL------LLQNSADSDISDLISFFTSQNI 937

  Fly  1300 YDWVLNSWGEYSERRYGGYGLNGSGATVWYNNKGY------HSMMAW----LNDLNSELLRTTMN 1354
            ...::|      :..|.....:.:...|.::.|.|      :|.|.:    |.::.|......:|
Human   938 MVTMIN------DSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLN 996

  Fly  1355 DSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAF-----GLVVASGSVYLVNERVNG 1414
            .:|:.     :.|...|.:..|          .:||.:.:.|     |::|.:...|...|....
Human   997 VTETI-----QIWSTPFFQEIT----------DIVFKIELYFQAALLGIIVTAMPPYFAMENAEN 1046

  Fly  1415 EKL----QQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLA 1475
            .|:    |.:|.|:....||:...|.|..:..:.||:.|..:|.|...::....:.:.::...:.
Human  1047 HKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIG 1111

  Fly  1476 FSFACVPSV----HVA----EKIFSDSSI-----AIVSIFCANLIVPLVTMGIILILGVVGDGPA 1527
            :    ||||    ::|    :||.:....     ::.::.|..:......||..:..        
Human  1112 Y----VPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIAT-------- 1164

  Fly  1528 WDDWRHALNQAF-LIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLV 1591
                  .|:.|| :|.||:.|....:...|   ::....|.::|:| :|...          |.|
Human  1165 ------ILHYAFCIIIPIYPLLGCLISFIK---ISWKNVRKNVDTY-NPWDR----------LSV 1209

  Fly  1592 GVAALIINVLIEWHLLRRLWQR------------VERLLDCTYRRELD------------KLGQL 1632
            .|.:..:..:: |..|.:.:::            ...|...:..|:|.            |..:|
Human  1210 AVISPYLQCVL-WIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERL 1273

  Fly  1633 KLVNIQSIFKSCVDTGEAVRAENLWLAY----------RRGHYAVRNVNFSVQRGECFGLLGKNG 1687
            |:..:...  .|.:...::...||...|          :....|.:.::|.|::||..||||.||
Human  1274 KVKELMGC--QCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNG 1336

  Fly  1688 AGKSTIFKLLTGQLQPDVGQIYFEQPG------------ISYCPQSNPLDPLLTTTECIRFYGRL 1740
            ||||||..:|.|.::|..||::.....            :.||||.|||.|..|..|....||.:
Human  1337 AGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAV 1401

  Fly  1741 RGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPV 1803
            :|:  .|:.:.:.|:....:|:.:....|:.|..|.:|||..|::..|.....|:|||::.|||.
Human  1402 KGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPK 1466

  Fly  1804 TRDMVYATIEQLLLAR-RAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHG-GYY-- 1864
            .:..::..|......| ||.:||:|.:.|.|.:|.|||::.:||:....:.|.|||:.| ||:  
Human  1467 AKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLE 1531

  Fly  1865 -AVTCFCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDV- 1927
             .:..:....:...|.|.:....|.|...:.::..|.:.:...      |...||:.|..|.:. 
Human  1532 IKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKE------DVQSLSQSFFKLEEAK 1590

  Fly  1928 -CVNVARFSLSRCRFETVF-ERILDSSESNGSNG 1959
             ...:..:|.|:...|.|| |...:..|.:.|.|
Human  1591 HAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCG 1624

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 34/149 (23%)
ABC_subfamily_A 859..1073 CDD:213230 72/229 (31%)
drrA 865..1162 CDD:130256 100/338 (30%)
ABC2_membrane_3 1230..1601 CDD:289468 78/409 (19%)
Mem_trans 1436..>1552 CDD:304621 23/129 (18%)
ABC_subfamily_A 1651..1857 CDD:213230 72/230 (31%)
drrA 1666..1945 CDD:130256 88/299 (29%)
ABCA5NP_061142.2 ABC2_membrane_4 202..403 CDD:289500 47/214 (22%)
ABC2_membrane_3 <214..416 CDD:289468 50/227 (22%)
CcmA 476..788 CDD:224054 95/321 (30%)
ABC_subfamily_A 478..701 CDD:213230 71/227 (31%)
ABC2_membrane_3 <943..1224 CDD:289468 60/334 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 2/18 (11%)
CcmA 1290..1615 CDD:224054 94/330 (28%)
ABC_subfamily_A 1290..1521 CDD:213230 72/230 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148352
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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