Protein Alignment ldd and Abca9

DIOPT Version :10

• Sequence 1: NP_001285513.1
• Gene: ldd / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: NP_671753.2
• Gene: Abca9 / 217262
• MGIID: 2386796
• Length: 1623
• Species: Mus musculus
• Alignment Length: 1602
• Identity: 393/1602 - (24%)
• Similarity: 635/1602 - (39%)
• Gaps: 396/1602 - (24%)

  Fly   599 NKFEVDNMQFYTKQF-PYPAFLN---------------------DVFKRGLYLAQ-GVQVAYLL- 639
            ||...:|..|:.|.| .:.|.:|                     ...|...::|| ||...:.:
Mouse   164 NKMICENSAFWEKGFVAFQAAINAGIIEMITNHSVMEELMSVIGSNMKMPPFIAQGGVATDFFIF 228

  Fly   640 -------GLVVFVALSV-RERIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGV 696
                   .|:.:::::: :||.:|     :.||..|||:..:..::|:||....:.|:..|:|.:
Mouse   229 FCVISFSSLIYYLSVNITQERQYM-----TTLMAMMGLRESAFWLSWSLMYAGFILVVAVLMSLI 288

  Fly   697 LYSGGILGYTNWFFMMFYCLSFGLCLISFCYM-----------------CTNFFNSANIGAVASA 744
            :.|..::..|.:..:....|.:||.||:..::                 .|.|:.|....|:...
Mouse   289 VKSAQVVVLTGFMVVFLLFLFYGLSLITLSFLMSVLIKKPFLTGLAIFILTVFWGSLGFTALYKH 353

  Fly   745 LLFFI--SLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQV-G 806
            |..|:  :||                 ||...:|||    |..:||.::..     |...:.: .
Mouse   354 LPAFVEWTLC-----------------FLSPFAFTT----GMAQLIHLDYD-----VNSNVNLNS 392

  Fly   807 PARSECAMA-LLMFLLDLLLYAVIGLAYQR-------------YKKTDNYSFVK------VSRSQ 851
            |..|...|| |.|.:||.|||.|:.|.:.:             :....:|.|.:      |..::
Mouse   393 PNNSYLIMATLFMLVLDALLYLVLALYFDKITLSKYGHQRSPLFFLKSSYWFKRRGASHVVLENE 457

  Fly   852 LD-----------------GKLGASLVNVSKLYGSKC----AVSNLSLDFARNQVSCLLGRNGAG 895
            :|                 ||....:.|:.|.|..|.    |:..|..|....|::.|||.:|||
Mouse   458 IDSDPSLNDSLEPVSPEFQGKEAIRIKNLKKEYSGKHGKVEALRGLGFDIYEGQITALLGHSGAG 522

  Fly   896 KSTLIKLLTGQIRQSSGKVLLAGEHQ------------VGVCWQDNILIPTLTAREHLQLYAQIK 948
            |:|||..|:|....::|.|.:..:..            .|||.|.|:....||.||:|:|:|:||
Mouse   523 KTTLINTLSGLSPPTTGSVTIYNQTVSEMDDSDAVLTITGVCPQSNVQFGFLTVRENLRLFAKIK 587

  Fly   949 IPPGGSGGV--EEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPC 1011
                   |:  .|:..||.|.||.|.....:...:..||||.:|:|.:.||.:..|.|::||||.
Mouse   588 -------GILPHEVEQEVQQVLQDLEMENIQDILAQNLSGGQKRKLTLGIAILGDPQVLLLDEPT 645

  Fly  1012 NGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSN 1076
            .|:|..:|..||.|::..|.||.::|:|.|||||..|:|..|.:.|||:....|...|::.....
Mouse   646 AGLDPLSRHRIWNLLKERRAGRVIVFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGIG 710

  Fly  1077 YSIRL---RCADATGVTFVIQK---AQQLLPQTQ------------------------VTHSGAA 1111
            |.:.|   ...|..|:|.:::|   ..:|..|::                        .::.|..
Mouse   711 YHLSLHLNEACDPEGITSLVKKHISDARLTTQSEERLVYILPLERTNKFPDLYRDLDRCSNQGIE 775

  Fly  1112 DYPHSLTINASYAEHLTPGAVEFLEL----------------LQSQVTAGSISDVELTTSSSLEQ 1160
            ||..|:|         |...| ||:|                |||.......|.|||....||
Mouse   776 DYGVSMT---------TLNEV-FLKLEGKSMADESDVGICGRLQSDGARDMESLVELEQVLSL-- 828

  Fly  1161 EFEQLNRNGEDAGPRRPASDRSG-VVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVL 1224
                               |.|| .|:|.|:...:.....|       .|...|....:.|:.||
Mouse   829 -------------------DSSGSSVSGMALWRQQLCAVAK-------VRFFKLKNERKSLMTVL 867

  Fly  1225 LL------PALFE--LCAMWFVSYRLEDDFDTVLPLSRSLY-------PQTAQFLSH----ERAT 1270
            ||      |.|.|  :..::..||.        ..||.|:|       ||..  |:|    .|..
Mouse   868 LLFGISFVPQLLEHLVYKVYHKSYS--------WGLSPSMYFLSPGQPPQDP--LTHLLVINRTG 922

  Fly  1271 SFSEKLYPQLR-----TSCDHLGECRVFNTSQQSYDWVLNSWGEYSERRYGGYGLNGSGATVWYN 1330
            |..:.....||     ...|.||...  .|.:..|:..:...||....|:          :|..|
Mouse   923 SSIDNFVHALRQQGIALDLDALGTRN--GTEEALYNGAITVLGEEKALRF----------SVACN 975

  Fly  1331 NKGYHSMMAWLNDLNSELLRTTMNDSE------SSILTLNEPWKLGFAELSTSSILRQAGDGSMV 1389
            .|..:.... |.|:.|..|....|.||      |::...:..::.||.             .:..
Mouse   976 AKRLNCFPV-LMDIISNGLLGIFNSSERIQTDRSTVFEEHMLYEYGFM-------------SNAF 1026

  Fly  1390 FILLIAFGLV--VASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVI 1452
            |.:.:|..|.  :|.||:....::|..   |....|:....||....:.|..:..|.|.:..::.
Mouse  1027 FWIPVAASLTPYIAMGSISDHKKKVLS---QLWTSGLYPSAYWCGQALVDIPIYFLILFLMQIMD 1088

  Fly  1453 LMFGMPVFVD-RQQLVGIIGLSLAFSFACVPSVHVAEKIFSD--SSIAIVSIFCANLIVPLVTMG 1514
            .:|....|:. .:.|:..|..|:.::.:.:...:|...||.:  .:..|.|.|..     :||:.
Mouse  1089 SVFSSEEFISVMESLLIQIPCSIGYASSLIFMTYVISFIFRNGRKNSGIWSFFFL-----IVTIF 1148

  Fly  1515 IILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASD 1579
            .|:...:...|     :...|...||:.|...:|.           .|:|.....||.      |
Mouse  1149 FIIATDINEYG-----FLELLICTFLVPPFTLIGS-----------LLIFSEVSYDSV------D 1191

  Fly  1580 LLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERLL-------DCTYR-------------- 1623
            .||...:.|:.:.:....::.|:.:.:||.|    ||.|       |..:|
Mouse  1192 YLGTSESQLVFLALLIPYLHFLLFFFILRCL----ERYLRKKSLRVDPVFRISPRSCPAVPNPEE 1252

  Fly  1624 -RELDKLGQLK-------LVNIQS-----IFKSCVDTGEAVRAENLWLAYRRGHYAVRNVNFSVQ 1675
             .|.|:..|::       :..:|:     |..||:......|.:..:...:: ..|.||::|.|:
Mouse  1253 PGEEDEDVQMERVRTTGAMATLQTDEKPVIIASCLRKEYIGRTKRCFSKMKK-KIATRNISFCVK 1316

  Fly  1676 RGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFEQPG-------ISYCPQSNPLDPLLTTTEC 1733
            :||..||||.|||||||...::||...|..||::.:..|       :.||||.|.|.|.||..|.
Mouse  1317 KGEVLGLLGHNGAGKSTTISMITGDTIPTAGQVFLKGSGGGAALGFLGYCPQENVLWPNLTVKEH 1381

  Fly  1734 IRFYGRLRGIRDLDQF--LDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEP 1796
            :..|..::|::..|..  :.|:::..:|:.:....||.||.|.:|||...::..|..|.||:|||
Mouse  1382 LELYAAVKGLKKKDAVVTITRLVNALKLQDHLKALVRTLSEGVKRKLCFVLSILGNPPVVLLDEP 1446

  Fly  1797 TSDMDPVTRDMVYATIEQLLL-ARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEH 1860
            ::.|||..:..::..|..... ..|..:||:|.::|.|.:|.|||::.:|::....|.|.|||:.
Mouse  1447 STGMDPEGQQQMWQAIRATFTNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1511

  Fly  1861 GGYYAVTC-FCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAIL 1924
            |..|.:.. ...|:|...|:..:.:..|.|...:.|:..:.:.:.|.      |...|||.|..|
Mouse  1512 GKDYLLEMKVKTPSQVEPLNTEIMRLFPQAARQERYSSLMVYKLPVE------DVRPLSEAFFKL 1570

  Fly  1925 CDVCVN--VARFSLSRCRFETVF-----ERILD--SSESNGS 1957
            ..:..|  :..:|||:...|.||     |:.||  ..|:|.|
Mouse  1571 ERLKENFDLEEYSLSQSTLEQVFLELSKEQELDDFGEEANSS 1612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ldd	NP_001285513.1	rim_protein	179..1867	CDD:130324	367/1500 (24%)
Abca9	NP_671753.2	rim_protein	<128..1600	CDD:130324	387/1588 (24%)