Protein Alignment ldd and ABCA3

DIOPT Version :10

• Sequence 1: NP_001285513.1
• Gene: ldd / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: NP_001080.2
• Gene: ABCA3 / 21
• HGNCID: 33
• Length: 1704
• Species: Homo sapiens
• Alignment Length: 1573
• Identity: 398/1573 - (25%)
• Similarity: 658/1573 - (41%)
• Gaps: 332/1573 - (21%)

  Fly   594 DANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVV-----FVALSV-RER 652
            ||..:..|:  .:....|:||||.|:.|.|.        |.:.|.|.|::     :.||:: |..
Human   228 DAATRQLFQ--RLTVTIKRFPYPPFIADPFL--------VAIQYQLPLLLLLSFTYTALTIARAV 282

  Fly   653 IWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLY------SGGILGYTNWFFM 711
            :..:|.|....||.|||.:.....||.|:.||.| :|.|....:|:      :..:|..::...:
Human   283 VQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFL-LIAASFMTLLFCVKVKPNVAVLSRSDPSLV 346

  Fly   712 MFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSF 776
            :.:.|.|.:..|||.:|.:.||:.||:.|.....|:|.:..|:..|......:::.:.....|..
Human   347 LAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLS 411

  Fly   777 TTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSE---C-AMALLMFLLDLLLYAVI-------- 829
            ..|.|.|...:.:.|.:..|:..|.|:  .|...:   | ...|.|.|||.:||.::
Human   412 NVAMAMGAQLIGKFEAKGMGIQWRDLL--SPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVF 474

  Fly   830 ----GLAYQRY-----------------KKTDNYSFVKVSRSQL------DGKLGASLVNVSKLY 867
                |:....|                 |:.::....|..|::.      |...|..:.::||::
Human   475 PGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVF 539

  Fly   868 --GSK--CAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG---------- 918
              |:|  .||.:|:|:....|::.|||.|||||:|.:.:|||....:||:..::|
Human   540 RVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQI 604

  Fly   919 EHQVGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGV--EEIRSEVAQTLQSLNFGKHESYPS 981
            ...:|:|.|.:||...||..|||..|||:|       |:  ::...||.|.|..:......:..|
Human   605 RKSLGLCPQHDILFDNLTVAEHLYFYAQLK-------GLSRQKCPEEVKQMLHIIGLEDKWNSRS 662

  Fly   982 WQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAK 1046
            ..||||.||:|.:.||.||...|:|||||.:|:||.:|:.||.|::|.:..|.::..|||||||.
Human   663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEAD 727

  Fly  1047 YLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQLLPQ--TQVTHSG 1109
            .|.|.:.||..|.:          :.|.|  |:.|:.....|....:.|.....|:  :|:.|.
Human   728 LLGDRIAIMAKGEL----------QCCGS--SLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHH- 779

  Fly  1110 AADYPHSLTINASYAE----------HLTPGAVEFLELLQSQVTAGSISDVELTT---------- 1154
              ..|::...:::.||          |...|....||..|.::...|.. ..:||
Human   780 --HVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFG-ASITTMEEVFLRVGK 841

  Fly  1155 --SSSLEQEFEQL-------NRNGED-------AGPRRPASDRSGVVAGPAMITDEPPTA----- 1198
              .||::.:..||       .|...|       .|...|:.       |...:.:|..||
Human   842 LVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSD-------GIGALIEEERTAVKLNT 899

  Fly  1199 -----CKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDTVLPLSRSLYP 1258
                 |:||..:..|:..:..|.::::...:|:|......|:..::|..|...|.:|.|:...|.
Human   900 GLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYG 964

  Fly  1259 QTAQFLSHERATSFSEKLYPQLRTSCD-----------HLGECRVFNTSQQSYDWVLNSWGEYSE 1312
            :|....|....:...::|...|:.:..           .|.|..:|..|.:.        |.::|
Human   965 RTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEG--------GGFNE 1021

  Fly  1313 RRYGGYGLNGSG----ATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGFAE 1373
            |..........|    ....:||:.|||....|..::: ||...:....:||:..|.|
Human  1022 RCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDN-LLFKLLCGPHASIVVSNFP------- 1078

  Fly  1374 LSTSSILRQAGDG--------SMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYW 1430
             ...|.|:.|.|.        .:...||.|...:.::.|:..|:||....|..|.:.||...::|
Human  1079 -QPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFW 1142

  Fly  1431 LVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSS 1495
            |.||:||.:..::..::.|||...|.:..|.....:...:.|.|.:.:|.:|.:::....|..::
Human  1143 LSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAA 1207

  Fly  1496 IAIVSIFCANLIVPLVTMGIILILGVVGDGPA--WDDWRHALNQAFLIFPIHALGDGFLELCKNY 1558
            .|...:...|::..:.|..::.|:.:    ||  .::....|:..||:.|.|.||.......:||
Human  1208 TAYTRLTIFNILSGIATFLMVTIMRI----PAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENY 1268

  Fly  1559 ----------MVALVFRRYDIDSYK--HPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLW 1611
                      :.|...::|:|...:  :..::..:||...::...|.|.||:..|||.:||:||
Human  1269 ETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRL- 1332

  Fly  1612 QRVERLLDCTYRR-----EL-------------------------DKLGQLKLV--NIQSIFKSC 1644
                |.:.|..||     ||                         |.|....|:  .:..:::..
Human  1333 ----RGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQR 1393

  Fly  1645 VDTGEAVRAENLWLAYRRGHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQ--------- 1700
            |..                 .||..::.:||:||||||||.|||||:|.||:|||:
Human  1394 VPL-----------------LAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAF 1441

  Fly  1701 -----LQPDVGQIYFEQPGISYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYE 1758
                 :..|||::   :..|.||||.:.|...:|..|.:..|.|||||  |.:...::..|....
Human  1442 VGGHRISSDVGKV---RQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLL 1503

  Fly  1759 LRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVV 1823
            |.|:.:..||..||||:|||:..:...|....:.:|||::.||||.|.:::.|:.:...:.:|::
Human  1504 LEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAII 1568

  Fly  1824 LTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTC-------------------- 1868
            :||||:.|.|.||.|:|::..||.....|||.|||:.|..|::..
Human  1569 ITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDL 1633

  Fly  1869 -FCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDVCVNVA 1932
             |.|...:......::..||| |||. :|.....|.:.:....:.|
Human  1634 TFPGSVLEDEHQGMVHYHLPG-RDLS-WAKVFGILEKAKEKYGVDD------------------- 1677

  Fly  1933 RFSLSRCRFETVF 1945
             :|:|:...|.||
Human  1678 -YSVSQISLEQVF 1689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ldd	NP_001285513.1	rim_protein	179..1867	CDD:130324	382/1472 (26%)
ABCA3	NP_001080.2	rim_protein	1..>43	CDD:130324
		rim_protein	<131..1699	CDD:130324	398/1573 (25%)