DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34120 and ABCA1

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:NP_005493.2 Gene:ABCA1 / 19 HGNCID:29 Length:2261 Species:Homo sapiens


Alignment Length:2452 Identity:560/2452 - (22%)
Similarity:917/2452 - (37%) Gaps:714/2452 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 EVRELLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPA 73
            ::|.||.|:|..|.||....|:.:|||:.:|::|..:||.|...|...|.:|.:.:|:.. .:|.
Human     6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG-TLPW 69

  Fly    74 AFSYICSIENRCQPAHPYEEYSHWKEAP----------------------LHSVIDV-------- 108
            ....||:..|.|      ..|....|||                      |:|..|.        
Human    70 VQGIICNANNPC------FRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKV 128

  Fly   109 ---------------VNAFVTDER-----------LHKAVVELAEKAN------FVSAITTLITS 141
                           :..|:.|..           |.|:.|:...:|:      |:......:||
Human   129 LRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTS 193

  Fly   142 --------DRFDIIRSNISEIISLVPE----IERRMNYSFDI----------------------- 171
                    :...:....:||:..|..|    .||.:..:.||                       
Human   194 LCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEAT 258

  Fly   172 -----------KHLFSNR----------------------ETFVKLGVLLCGHPFPNTDTIPLVN 203
                       :.|||.|                      :.:..:..::||||......|..:|
Human   259 KTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLN 323

  Fly   204 EILESEDFSQ---ANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVTSTNQGKLTWNTIKP 265
             ..|..::..   .|..|.||      ..:.|..|    |.||..|.:::.|:...::.|..:||
Human   324 -WYEDNNYKALFGGNGTEEDA------ETFYDNST----TPYCNDLMKNLESSPLSRIIWKALKP 377

  Fly   266 IIQGRILYTPANAMTESVVKFSNASFEELDRLKQLSRAAATILTKLHT----------------- 313
            ::.|:|||||....|..|:...|.:|:||.....|......:..|:.|                 
Human   378 LLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDS 442

  Fly   314 --NATFQE---------AFDNLLKLAKSPL-VKSLVGDDFDIGEIERVFEYIRTNQLIYDILTTV 366
              |..|.|         |.|.:..|||.|. |:|..|..:...|     .:..|||.|    .|:
Human   443 RDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWRE-----AFNETNQAI----RTI 498

  Fly   367 ADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLAALNLEDVGLKQAS--------YRLHMDTD 423
            :..|:||:.::.|.:.:...|..::.||...:.|.|.:..  .|:...|        |::.||.|
Human   499 SRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVF--TGITPGSIELPHHVKYKIRMDID 561

  Fly   424 NTQPTFENRNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRS 487
            |.:.|.:.::.:|.|||......|::| ..||..|:.:|:..||                   |.
Human   562 NVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAII-------------------RV 607

  Fly   488 LSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRV 552
            |:|                                                              
Human   608 LTG-------------------------------------------------------------- 610

  Fly   553 TTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPA 617
             ||                      |:.|:                          |.:|.|||.
Human   611 -TE----------------------KKTGV--------------------------YMQQMPYPC 626

  Fly   618 FLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMS 682
            :::|:|.|  .:::.:.:...|..:..||:.::..::.:|:|....||.|||.......:|.:.|
Human   627 YVDDIFLR--VMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISS 689

  Fly   683 FLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLF 747
            .:.|.|...|:..:|..|.:|.|::...:..:...|.:..|..|::.:..|:.||:.|....:::
Human   690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIY 754

  Fly   748 FISLCPFIIVLMFD----AKLSVFESFLVDLSF-----------TTAFAKGWGELIRMELQQEGL 797
            |....|:::.:.:.    ..|.:|.|.|..::|           .......|..|....::::|.
Human   755 FTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGF 819

  Fly   798 TVRHLIQVGPARSECAMALLMFLLDLLLYAVI------------GL----------AYQRYKKTD 840
            .:             ..::.|.|.|..||.|:            |:          :|...:::|
Human   820 NL-------------TTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESD 871

  Fly   841 NYSFVKVSRSQLDG----------KLGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNG 893
            ..|....::.::..          |||.|:.|:.|:|  |.|.||..|:|:|...|::..||.||
Human   872 EKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNG 936

  Fly   894 AGKSTLIKLLTGQIRQSSGKVLLAGE----------HQVGVCWQDNILIPTLTAREHLQLYAQIK 948
            |||:|.:.:|||....:||...:.|:          ..:|||.|.|:|...||..||:..||::|
Human   937 AGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLK 1001

  Fly   949 IPPGGSGGVEE--IRSEVAQTLQSLNFG----KHESYPSWQLSGGYRRRLCVAIAFIASPSVVIL 1007
                   |:.|  :::|:.|  .:|:.|    |.:|..| |||||.:|:|.||:||:....||||
Human  1002 -------GLSEKHVKAEMEQ--MALDVGLPSSKLKSKTS-QLSGGMQRKLSVALAFVGGSKVVIL 1056

  Fly  1008 DEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRL 1072
            |||..|||..:|:.||:|:.:.||||.:|.:||.||||..|.|.:.|:.:|::....|...|:..
Human  1057 DEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQ 1121

  Fly  1073 CTSNYSIRL----------RCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTINASYAEHL 1127
            ..:.|.:.|          .|.:::.....::|...:...:.....|:.....:|||:.|...:|
Human  1122 LGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNL 1186

  Fly  1128 TPGAVE-------------------------FLELLQSQVTAGSISDVELTTSSSLEQEFEQL-- 1165
            ....|.                         |:||...  ....:||:.:::....|...|::  
Human  1187 IRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHE--IDDRLSDLGISSYGISETTLEEIFL 1249

  Fly  1166 ---NRNGEDAGP----------RRPASDRSGVV--------AGPAMITDEPPT------------ 1197
               ..:|.||..          ||...|:...:        |.|.....:|.:            
Human  1250 KVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGK 1314

  Fly  1198 ----------ACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAM----------------- 1235
                      ..:||..|:.|||....|:.:.....::|||:|...|:                 
Human  1315 GSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLEL 1379

  Fly  1236 --W-------FVSYRLEDDFDTVLPLSRSL--------------------------------YPQ 1259
              |       |||....:|..| |.|..:|                                .||
Human  1380 QPWMYNEQYTFVSNDAPEDTGT-LELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQ 1443

  Fly  1260 TAQFLSHERATSFSEKLYPQLRTSCDHLGE----C-----------RVFNTSQQSYDWVLNSWGE 1309
            |...| .:......:...|..:.|.|.:.:    |           |..||:....|....:..:
Human  1444 TIMDL-FQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISD 1507

  Fly  1310 Y-------------------SERRYGGYGLNGS-------------------------------- 1323
            |                   :|.||||:.|..|                                
Human  1508 YLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADR 1572

  Fly  1324 ----------------GATVWYNNKGYHSMMAWLNDLNSELLRTTM----NDSESSILTLNEPWK 1368
                            ...||:||||:|::.::||.:|:.:||..:    |.|...|...|.|..
Human  1573 FLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLN 1637

  Fly  1369 LGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVA 1433
            |...:||..:::..:.|..:...::.|...|.||..|:|:.|||:..|..|.:.||..|.|||..
Human  1638 LTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSN 1702

  Fly  1434 LVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAI 1498
            .|||....|:...:.:::.:.|....:|....|..:..|.|.:.::..|.::.|..:|...|.|.
Human  1703 FVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAY 1767

  Fly  1499 VSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALV 1563
            |.:...||.:.:.......:|.:..|... ::....|...|||||...||.|.:::.||..:|..
Human  1768 VVLTSVNLFIGINGSVATFVLELFTDNKL-NNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADA 1831

  Fly  1564 FRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERLL------DCTY 1622
            ..|:..:.:..||:.||:||:..|:.:.||...:|.|||::....|. :.|...|      |...
Human  1832 LERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRP-RPVNAKLSPLNDEDEDV 1895

  Fly  1623 RRE----LDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGHY-AVRNVNFSVQRGECFGL 1682
            |||    ||..||..::.|:.:.|                .|||... ||..:...:..||||||
Human  1896 RRERQRILDGGGQNDILEIKELTK----------------IYRRKRKPAVDRICVGIPPGECFGL 1944

  Fly  1683 LGKNGAGKSTIFKLLTGQLQPDVGQIYFEQPGI-----------SYCPQSNPLDPLLTTTECIRF 1736
            ||.||||||:.||:|||......|..:..:..|           .||||.:.:..|||..|.:.|
Human  1945 LGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEF 2009

  Fly  1737 YGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSD 1799
            :..|||:  :::.:..:..:....|..|.:....|.||||:|||:.|:...|..|.|.:||||:.
Human  2010 FALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTG 2074

  Fly  1800 MDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHG-GY 1863
            |||..|..::.....::...|:|||||||:.|.|.||.|:|::..|:.....|.|.||:..| ||
Human  2075 MDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGY 2139

  Fly  1864 YAVTCFCG------PAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFA 1922
            ..|....|      |.|.     ......||:...:.:.:.|::    :.|.||..   |:.:|:
Human  2140 TIVVRIAGSNPDLKPVQD-----FFGLAFPGSVLKEKHRNMLQY----QLPSSLSS---LARIFS 2192

  Fly  1923 ILCD--VCVNVARFSLSRCRFETVFERIL-DSSESNGSN--GVHKDQ 1964
            ||..  ..:::..:|:|:...:.||.... |.|:.:...  .:||:|
Human  2193 ILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQ 2239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 31/138 (22%)
ABC_subfamily_A 859..1073 CDD:213230 90/231 (39%)
drrA 865..1162 CDD:130256 105/349 (30%)
ABC2_membrane_3 1230..1601 CDD:289468 111/514 (22%)
Mem_trans 1436..>1552 CDD:304621 27/115 (23%)
ABC_subfamily_A 1651..1857 CDD:213230 77/219 (35%)
drrA 1666..1945 CDD:130256 95/300 (32%)
ABCA1NP_005493.2 rim_protein 6..2236 CDD:130324 557/2447 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1312 3/28 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 134 1.000 Domainoid score I5010
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.720

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