DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ldd and ced-7

DIOPT Version :10

Sequence 1:NP_001285513.1 Gene:ldd / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:NP_001255012.1 Gene:ced-7 / 176352 WormBaseID:WBGene00000421 Length:1758 Species:Caenorhabditis elegans


Alignment Length:1937 Identity:430/1937 - (22%)
Similarity:741/1937 - (38%) Gaps:505/1937 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 PFPNTDTIPLVNEILESE---------------DFSQAND----------AEIDAMPTRRRRRYE 231
            |.|::..:..:...|::|               ..:::||          ||...:|.::..|..
 Worm     8 PMPHSTIVRWLRRYLQNEKAKRKAKESDIECSSSENESNDSTPLRGDGQLAESSRIPKKKMNRLR 72

  Fly   232 DLPTDWRPTKYCKRLYRDVTSTNQGKLTWNTIKPIIQ----GRILYTPANAMTESVVKFSNASFE 292
                     ::...|::|.....:.|: |...:.||.    |.::|.        |||  ||.  
 Worm    73 ---------QFSLLLWKDWVLLRRNKV-WTLFELIIPCLLLGPLVYL--------VVK--NAD-- 115

  Fly   293 ELDRLKQLSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDI-GEIERVFEYIRTN 356
                               ||::.     :|:.             |:|.: |.:|.||  :.:|
 Worm   116 -------------------HTSSP-----ENIY-------------DNFQVKGTVEDVF--LESN 141

  Fly   357 QL--IYDILTTVADLMDCVSADRFEAVESVEELHKRAYELNQN-KLFLAALNLEDVGLKQASYRL 418
            .:  ||......:|::...::....|..:|::|.|:..|..|: ||.|:..|  :...:|....|
 Worm   142 FIKPIYKRWCLRSDVVVGYTSKDAAAKRTVDDLMKKFAERFQSAKLKLSVKN--ESSEEQLLTVL 204

  Fly   419 HMDTDNTQPTFENRNRFWFPGPADSMVIDLKYHRGFVQLKQMVDLGIIKSK---REEAGFAPEED 480
            ..|......||...|.:     |..:|.|              ::.:...|   |...|..|||.
 Worm   205 RNDLPMLNETFCAINSY-----AAGVVFD--------------EVDVTNKKLNYRILLGKTPEET 250

  Fly   481 -----------GPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEA 534
                       ||.|||           .:..|                  ::|....||.....
 Worm   251 WHLTETSYNPYGPSSGR-----------YSRIP------------------SSPPYWTSAFLTFQ 286

  Fly   535 TTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKN 599
            ..|..|.|             .:|.||.|||.:          ..:||              .:.
 Worm   287 HAIESSFL-------------SSVQSGAPDLPI----------TLRGL--------------PEP 314

  Fly   600 KFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFV-ALSVRERIWMRESRNSML 663
            :::..::..:...||                      ::...|.|: .:.:...|..........
 Worm   315 RYKTSSVSAFIDFFP----------------------FIWAFVTFINVIHITREIAAENHAVKPY 357

  Fly   664 MRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYM 728
            :.:|||.......|..:|:||:..|||  :..::....::.:.:...::...|.:||..:.|...
 Worm   358 LTAMGLSTFMFYAAHVVMAFLKFFVIF--LCSIIPLTFVMEFVSPAALIVTVLMYGLGAVIFGAF 420

  Fly   729 CTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKL-----SVFESFLVDLSFTTAFA---KGWG 785
            ..:|||:.| .|:.:.|:.:.::      :....||     .:...||..|:...|||   :...
 Worm   421 VASFFNNTN-SAIKAILVAWGAM------IGISYKLRPELDQISSCFLYGLNINGAFALAVEAIS 478

  Fly   786 ELIRMELQQEGLTVRHLIQVGPARSECAMALLMFLLDLLLYAVIGLAYQRYKKTDNYSFVKV--- 847
            :.:|.|.:   |.:.::............||:|.::|:|..::..|.....:.:.::|...:   
 Worm   479 DYMRRERE---LNLTNMFNDSSLHFSLGWALVMMIVDILWMSIGALVVDHIRTSADFSLRTLFDF 540

  Fly   848 --------------------------------------SRSQLDGKLGA--------------SL 860
                                                  |.|.|:|...|              :|
 Worm   541 EAPEDDENQTDGVTAQNTRINEQMNPMASTSLNPPNADSDSLLEGSTEADGARDTARADIIVRNL 605

  Fly   861 VNVSKLYGSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG------- 918
            |.:....|.: ||..|||...|.|.|.|||.|||||||....:.|.||.::|::.:.|       
 Worm   606 VKIWSTTGER-AVDGLSLRAVRGQCSILLGHNGAGKSTTFSSIAGIIRPTNGRITICGYDVGNEP 669

  Fly   919 ---EHQVGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVE-EIRSEVAQTLQSLNFGKHESY 979
               ...:|:|.|.|.|...||..|||:|...:|      |..| :.:.::.:.|..:.....|:.
 Worm   670 GETRRHIGMCPQYNPLYDQLTVSEHLKLVYGLK------GAREKDFKQDMKRLLSDVKLDFKENE 728

  Fly   980 PSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDE 1044
            .:..||||.:|:|||.:|.|....||:||||..|:|..||:|:.:|:||.:..|.::..||:|||
 Worm   729 KAVNLSGGMKRKLCVCMALIGDSEVVLLDEPTAGMDPGARQDVQKLVEREKANRTILLTTHYMDE 793

  Fly  1045 AKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATG------------VTFVIQKAQ 1097
            |:.|.|.:.||.:|:::|..:...|::...:.|.:.: ..|..|            .|..:::|:
 Worm   794 AERLGDWVFIMSHGKLVASGTNQYLKQKFGTGYLLTV-VLDHNGDKRKMAVILTDVCTHYVKEAE 857

  Fly  1098 Q----------LLP-----------------QTQVTHSGAAD-YPHSLTINASYAEHLTPG-AVE 1133
            :          :||                 |.:...|...| .|::|....:..|..:.| ::.
 Worm   858 RGEMHGQQIEIILPEARKKEFVPLFQALEAIQDRNYRSNVFDNMPNTLKSQLATLEMRSFGLSLN 922

  Fly  1134 FLELLQSQVTAGSISDVEL--------------------------TTSSSLEQEFEQLNRNGEDA 1172
            .||  |..:|.|...|..:                          |.||:...:..|...:.:..
 Worm   923 TLE--QVFITIGDKVDKAIASRQNSRISHNSRNASEPSLKPAGYDTQSSTKSADSYQKLMDSQAR 985

  Fly  1173 GPRRPASDRSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALF--ELCAM 1235
            ||     ::|||....|           ||..:|.|:..:..||:..|...:|:|.:.  .:.::
 Worm   986 GP-----EKSGVAKMVA-----------QFISIMRKKFLYSRRNWAQLFTQVLIPIILLGLVGSL 1034

  Fly  1236 WFVSYRLEDDFDTVLPLSRSLYPQTAQ-------FLS---HERATSFSEKLYPQLRTSCDHLGEC 1290
            ..:.....|.|..     |||.|...:       |.:   .|.|.:| ||:   ||.|    |..
 Worm  1035 TTLKSNNTDQFSV-----RSLTPSGIEPSKVVWRFENGTIPEEAANF-EKI---LRKS----GGF 1086

  Fly  1291 RV--FNTSQQSYDWVLNSWGEYSERRYGGYGLNGSGATVWYNNKGYHSMMAWLNDLNSELLRTTM 1353
            .|  :||.....:...:..||...... |..:|.......:|.:.||.:...::.:|...|..|:
 Worm  1087 EVLNYNTKNPLPNITKSLIGEMPPATI-GMTMNSDNLEALFNMRYYHVLPTLISMINRARLTGTV 1150

  Fly  1354 NDSESSILTLNEPWKLGFAELSTSSIL-RQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKL 1417
            :...||.:.|..      ...|.|::| .|..|..:..:|::.|.:|.::..::|:.||......
 Worm  1151 DAEISSGVFLYS------KSTSNSNLLPSQLIDVLLAPMLILIFAMVTSTFVMFLIEERTCQFAH 1209

  Fly  1418 QQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVP 1482
            ||.|.|:|.:|::..:|::|   .:|..::||:.:.|| :........|..:|.....:.|:.||
 Worm  1210 QQFLTGISPITFYSASLIYD---GILYSLICLIFLFMF-LAFHWMYDHLAIVILFWFLYFFSSVP 1270

  Fly  1483 SVHVAEKIFSDSSIAIVSIFCANLIVP----LVTMGIILILGVVGDGPAWDDWRHAL--NQAFLI 1541
            .::....:|...|.|.|.:....:::.    |....|.:|..:       |:|..::  |....:
 Worm  1271 FIYAVSFLFQSPSKANVLLIIWQVVISGAALLAVFLIFMIFNI-------DEWLKSILVNIFMFL 1328

  Fly  1542 FPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLL------GRHFTALLLVGVAALIINV 1600
            .|.:|.|...:               .|::|...|.|:.|      |::...:...||.:..:.|
 Worm  1329 LPSYAFGSAII---------------TINTYGMILPSEELMNWDHCGKNAWLMGTFGVCSFALFV 1378

  Fly  1601 LIEWHLLRRLWQRVERLLDCTYRRELDKLGQLKLVNIQSIFKSCVDTGE------AVRAENLWLA 1659
            |:::..:||...:|..:...::......:|.|.:         |....|      .|.::|..|.
 Worm  1379 LLQFKFVRRFLSQVWTVRRSSHNNVQPMMGDLPV---------CESVSEERERVHRVNSQNSALV 1434

  Fly  1660 YRR-----GHY-AVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYF------EQ 1712
            .:.     |.: ||..:..:|.:.|||||||.|||||:|.|.:||||.....|:...      |.
 Worm  1435 IKDLTKTFGRFTAVNELCLAVDQKECFGLLGVNGAGKTTTFNILTGQSFASSGEAMIGGRDVTEL 1499

  Fly  1713 PGISYCPQSNPLDPLLTTTECIRFYGRLRGIRDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRK 1777
            ..|.||||.:.|...||..|.:....::.|..:.....:.:|:...:..:.|..||..|||.:||
 Worm  1500 ISIGYCPQFDALMLDLTGRESLEILAQMHGFENYKAKAELILECVGMIAHADKLVRFYSGGQKRK 1564

  Fly  1778 LTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARR----AVVLTSHSVSEIEHLCQR 1838
            ::|.|.....|..:::||||:.:||..|..|:   |.||..|.    |::|||||:.|.|.||.|
 Worm  1565 ISVGVALLAPTQMIILDEPTAGIDPKARREVW---ELLLWCREHSNSALMLTSHSMDECEALCSR 1626

  Fly  1839 VAVLRAGQVIASDSPQRLKSEHGGYYAVT-CFCGPAQQAILSRSLNQRLPGA 1889
            :|||..|.:||..|.|.|||.:|..|.:| ....|.|:.::.:.:..|||.:
 Worm  1627 IAVLNRGSLIAIGSSQELKSLYGNNYTMTLSLYEPNQRDMVVQLVQTRLPNS 1678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lddNP_001285513.1 rim_protein 179..1867 CDD:130324 424/1912 (22%)
ced-7NP_001255012.1 rim_protein 68..>115 CDD:130324 13/66 (20%)
rim_protein <219..1747 CDD:130324 379/1663 (23%)

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