DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and abt-5

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_001364572.1	Gene:	abt-5 / 173081	WormBaseID:	WBGene00000023	Length:	1582	Species:	Caenorhabditis elegans

Alignment Length:	1557	Identity:	362/1557 - (23%)
Similarity:	638/1557 - (40%)	Gaps:	336/1557 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 FGGSGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKR--GLYLAQGVQVAYLLGLVVFVALSVRE 651
            ||.|..||..:.. ::|  |..|.:....|....|.:  ||..|    |..|:.::     ||..
Worm   164 FGLSQRANNTSSI-IEN--FDIKLYSITNFEESGFGQNFGLLFA----VCMLMPVI-----SVAR 216

  Fly   652 RIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCL 716
            .:.:.:|.....:.::||......:...|...::...:..|:|           |.:.|.|..|.
Worm   217 ALVVEKSSVKPYLTTIGLPLWMFYLEHFLFGVIKNTFLITLLS-----------TLYIFSMDNCP 270

  Fly   717 SFGLC--------LISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLM-------------- 759
            ::.|.        .:||..:||:...... ..|...::.:|:|    |:.|
Worm   271 TYVLAGIFMYTCHCVSFSILCTSILPFGK-RIVEGMVIIWITL----IIAMHLSLEFEFDWLFWV 330

  Fly   760 ------FDAKLSVFESFLV---DLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSECAMA 815
                  :..||.|..:||.   :.:.|:|......:.::......|:.:           .|.:.
Worm   331 PLLNPNYSLKLFVDATFLASGPNGTPTSALFSSKKKTLQSAAVYFGIMI-----------SCTVV 384

  Fly   816 LLMFLLDL-LLYAVIGLA-YQRYKKTDNYSFVKVSRSQLDGK-------------------LGAS 859
            :|:..:.: .||..:|.| ::|:.:.  ..|.|..||:::.:                   .|::
Worm   385 MLVAAIFMEKLYTFVGHAIFKRFWRI--LGFSKGKRSKIEERGDGVEDRSTILQCKETVEGRGSA 447

  Fly   860 LVNVS-----KLY--GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLA 917
            :.::.     |:|  |.| ||:.|||...|.|||.|||.||.||||...::||..:.:.|||::.
Worm   448 IADIELSGLVKVYQNGEK-AVNGLSLRAIRGQVSILLGHNGCGKSTTFGMITGMHQATEGKVMIG 511

  Fly   918 G----------EHQVGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLN 972
            |          ...:|.|.|.|.:...||..|||:|...:|   |.||| .:.:.:....|:.:.
Worm   512 GIDANANRAEARELIGYCPQYNPIYDELTVWEHLRLVNALK---GRSGG-SDFKMDAESLLKQIE 572

  Fly   973 FGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIF 1037
            .....:..:..||||.:|:|||.:|.|....|::||||..|:|..||.|:..::..::..|.::.
Worm   573 LTDKRNTLAKNLSGGMKRKLCVCMAMIGGSRVILLDEPTAGMDPSARIDVQNMLALVKADRTILL 637

  Fly  1038 ATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQR------LCT-----------------SNYSI 1079
            .||:||||:.|.|.:.:|.:|::.|..|:..|::      |.|                 :.|.:
Worm   638 TTHYMDEAEKLGDWIFVMSHGKMAASGSKHYLKQKYGGGMLLTLVFKSVHDPMRPRKSYETAYDV 702

  Fly  1080 RLRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTINASYAEH---------LTPGAVEFL 1135
               |........|..:..|:: :..:..:..:..|..|.|..|..|.         |.|...|..
Worm   703 ---CKTVCSTALVKDERGQMI-EISILETEKSRLPTLLKILESVMEEDYNNPEFQALEPDIQEKC 763

  Fly  1136 ELLQSQVTAGSISDVELTTSSSLEQEF--------EQLNRNGEDAGPRRPASDRSGVVAGPAMIT 1192
            ..|: ..|.|       .:.|||||.|        :.:|..|.|....|
Worm   764 RTLE-LATIG-------VSMSSLEQVFIKIGDECDDIMNGTGVDKKTER---------------- 804

  Fly  1193 DEPPTACKQFRL----------------LMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVS-- 1239
            .|..:...|:::                |:.||..:|.||...:...::||    |..:|..:
Worm   805 QEKFSTLVQYKIQQPKQGFSKLMMVVWALLQKRAYYLYRNPVQITLQIILP----LLTLWLFAVP 865

  Fly  1240 -YRLE------DDFDTVLPLSRSLYPQTAQFLSHERATSFSEKLYPQLRTSCDHLGECRVFNTSQ 1297
             .|||      .|.::..|   |.||.:...|..|...  .::|       .::|.....|...:
Worm   866 FLRLEPKPPKLSDIESFDP---SQYPHSTVLLQLENEN--DDRL-------ANYLNSFSNFEVVK 918

  Fly  1298 QSYDWVLNSWGEYSERRYG------GY--GLNGSGATVWYN-NKGYHSMMAWLNDLNSEL-LR-- 1350
            ..|:   :.:| |..::|.      |:  .:|..|.:.:|. ::|..:....:|.:.|.: ||
Worm   919 VGYN---DHYG-YLVKKYSQVFKTLGFIVKVNKKGDSKFYKISQGDKNAAILMNIIASAMYLRDP 979

  Fly  1351 --TTMNDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVN 1413
              |.:....|.::.:|:| |:.:..|::..:...      :|.||:..|:.:.| :|||:.|::.
Worm   980 SVTKLPHVTSRVIWMNDP-KIKYEGLASFFLFEN------IFFLLVLAGIFIQS-TVYLIEEKIC 1036

  Fly  1414 GEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSF 1478
            ....||.|.|:|.:.||.|..:||:|:....|:..:..::.||  |.......:.:|...|.|.|
Worm  1037 KFAHQQYLTGLSTIAYWGVVFLWDFLLFTFFLLYTIGFLISFG--VLQGHIHEIVVIFYGLLFYF 1099

  Fly  1479 ACVPSVHVAEKIFSDSSIA--IVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLI 1541
            |  |.|::...:.:..:..  ::.:||.   :|.:...|:   ..:.:.|....:...:...|.|
Worm  1100 A--PLVYLTSALINTPTRGNFLLYMFCC---IPWLAYSIV---SELHNFPPIQKYSDEIEYGFRI 1156

  Fly  1542 F-PIHALGDGFLE-LCKNYMVALVFRRYDIDSYKHPLASDLLGRH---FTALLLVGVAALIINVL 1601
            | |    ..|||. |.|  :.||.:.:..:|.:...|.:  |..:   |..|:.:....:.:.:|
Worm  1157 FNP----SIGFLAGLMK--IAALNYPKSGLDKHFEHLTN--LWTYEGIFFELMFLFFGGIFLTIL 1213

  Fly  1602 IEWHLL----RRLWQRVERLLDCTYRRELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRR 1662
            :....|    |..::...|......|:....:...|.|..:......||..|.|...: .|....
Worm  1214 LGCATLKPFRRACFRGTRRRSQPRERKRYKGIESCKAVKEEEQLVQEVDKNETVLVID-GLVKDF 1277

  Fly  1663 GHY-AVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYF------EQPGISYCPQ 1720
            |.: ||.:::.||...||||:||.|||||:|.|.::||...|..|....      |...|.||||
Worm  1278 GKFRAVNDLSISVGHEECFGMLGANGAGKTTTFDIITGLTMPTGGSATIDGHDITETIHIGYCPQ 1342

  Fly  1721 SNPLDPLLTTTECIRFYGRLRGIRDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCC 1785
            .:.:...::..:.:|...:|:|..::.:.::.|||...:..:....|:|.|||.:||::|.:...
Worm  1343 FDAMLQQISCRQTLRIMAKLQGYPNVKEVVELVLDCVGMSDFGYKLVKNCSGGQKRKISVGIALM 1407

  Fly  1786 GCTPTVLMDEPTSDMDPVTR----DMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQ 1846
            .....:::||||:.:||..|    |:::...||   |:.::||||||:.|.|.||.|:.:||.|:
Worm  1408 SRATCIILDEPTAGIDPRARREIWDIIHEMREQ---AKCSIVLTSHSMEECEALCTRIGILRKGE 1469

  Fly  1847 VIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSL 1911
            :||..:.|.|||::|..|.:|         ::..||       .||:    |:..:|....|.::
Worm  1470 MIALGTSQSLKSQYGNTYMMT---------LILNSL-------EDLE----SVCVIVSEEMPDAV 1514

  Fly  1912 GDAPLLSELFAILCDV--------------------CVNVARFSLSRCRFETVFERILDSSE 1953
            ...|..|...:|:.::                    ..|...:.|::...|..|.|::.:.|
Worm  1515 LKTPESSLTTSIVWELPKSKSDKWSEKYNQVEVLAKKANAKDYMLTQASLEDTFIRLITTEE 1576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	28/168 (17%)
		ABC_subfamily_A	859..1073	CDD:213230	78/236 (33%)
		drrA	865..1162	CDD:130256	100/340 (29%)
		ABC2_membrane_3	1230..1601	CDD:289468	86/400 (22%)
		Mem_trans	1436..>1552	CDD:304621	24/118 (20%)
		ABC_subfamily_A	1651..1857	CDD:213230	72/216 (33%)
		drrA	1666..1945	CDD:130256	88/308 (29%)
abt-5	NP_001364572.1	rim_protein	<419..1569	CDD:130324	304/1252 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750