DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34120 and Abcg5

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	713	Identity:	145/713 - (20%)
Similarity:	260/713 - (36%)	Gaps:	204/713 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   873 VSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQS---SGKVLLAG--------EHQVGVCW 926
            :.::||.....|..|:||.:|:||:||:..::|::|::   .|:|.:.|        :..|....
  Rat    70 LKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCVSYLL 134

  Fly   927 QDNILIPTLTAREHLQLYAQIKIPPGGSG----GVEEIRSEVA------QTLQSLNFGKHESYPS 981
            |.::.:.:||.||.|:..|.:.:....:.    .||.:.:|::      |.:.:.|||
  Rat   135 QSDVFLSSLTVRETLRYTAMLALRSSSADFYDKKVEAVLTELSLSHVADQMIGNYNFG------- 192

  Fly   982 WQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDA-KARKDIWQLIERLRQGRAVIFATHF-MDE 1044
             .:|.|.|||:.:|...:..|.|::||||..|:|. .|...:..|:|..|:.|.||...|. ..|
  Rat   193 -GISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQPRSE 256

  Fly  1045 AKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQKAQQLLPQTQVTHSG 1109
            ..:..|.:.|:..|.::.                    |.....:...........|:    ||.
  Rat   257 LFHHFDKIAILTYGELVF--------------------CGTPEEMLGFFNNCGYPCPE----HSN 297

  Fly  1110 AADYPHSLT---INASYAEHLTPGAVEFLE--LLQSQVTAGSISDVELTTSSSLEQEFEQLNRNG 1169
            ..|:...||   ..:...|..|...|:.||  ..||.:....:.::|.|      :..:.|
  Rat   298 PFDFYMDLTSVDTQSREREIETYKRVQMLESAFRQSDICHKILENIERT------RHLKTL---- 352

  Fly  1170 EDAGPRRPASDRSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVL---LLPALFE 1231
                |..|..            |..||....:..:|:.:..|:|.||.::::..|   |:..||
  Rat   353 ----PMVPFK------------TKNPPGMFCKLGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLF- 400

  Fly  1232 LCAMWFVSYRLEDDFDTVLPLSRSLYPQTAQFLSHERATSF-----SEKLYPQLRTSCDHLGECR 1291
               :.|...|::::.     |..::..:.........||.:     :..|:|.||...|
  Rat   401 ---LIFYLLRVQNNM-----LKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSD------ 451

  Fly  1292 VFNTSQQSYDWVLNSWGEYSERRYGGYGLNGSG----ATVWYNNKGYHSMMAWLNDLNSELLRTT 1352
                 |:|.|.:...|     :....|.|:...    |||.:::..|     |...|..|:.|
  Rat   452 -----QESQDGLYQKW-----QMLLAYVLHALPFSIVATVIFSSVCY-----WTLGLYPEVAR-- 499

  Fly  1353 MNDSESSILTLNEPWKLG-FAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNE-----R 1411
            .....:::|.   |..:| |..|....:::.....:.:..||...||::.||.:..:.|     :
  Rat   500 FGYFSAALLA---PHLIGEFLTLVLLGMVQNPNIVNSIVALLSISGLLIGSGFIRNIEEMPIPLK 561

  Fly  1412 VNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVC--LVVILMFGMPVFVDRQQLVGIIGLSL 1474
            :.|....|:.|                         |  |||...:|:
  Rat   562 ILGYFTFQKYC-------------------------CEILVVNEFYGL----------------- 584

  Fly  1475 AFSFAC------VPS---------VHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVV 1522
              :|.|      ||:         :...||....::    |.|..|.::....:..::|||:|
  Rat   585 --NFTCGGSNTSVPNNPMCSMTQGIQFIEKTCPGAT----SRFTTNFLILYSFIPTLVILGMV 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230	57/222 (26%)
		drrA	865..1162	CDD:130256	73/316 (23%)
		ABC2_membrane_3	1230..1601	CDD:289468	58/325 (18%)
		Mem_trans	1436..>1552	CDD:304621	18/104 (17%)
		ABC_subfamily_A	1651..1857	CDD:213230
		drrA	1666..1945	CDD:130256
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		ABCG_White	50..276	CDD:213201	57/233 (24%)
		3a01204	61..646	CDD:273361	145/713 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000