DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG34120 and Abca1

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:XP_006537617.1 Gene:Abca1 / 11303 MGIID:99607 Length:2263 Species:Mus musculus


Alignment Length:2482 Identity:567/2482 - (22%)
Similarity:927/2482 - (37%) Gaps:772/2482 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 EVRELLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPA 73
            ::|.||.|:|..|.||....|:.:|||:.:|::|..:||.|...|...|.:|.:.:|:.. .:|.
Mouse     6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG-TLPW 69

  Fly    74 AFSYICSIENRCQPAHPYEEYSHWKEAP---------------------------------LHSV 105
            ....||:..|.|      ..|....|||                                 :|.|
Mouse    70 VQGIICNANNPC------FRYPTPGEAPGVVGNFNKSIVSRLFSDAQRLLLYSQRDTSIKDMHKV 128

  Fly   106 IDVVNA------------FVTDER-----------LHKAVVELAEKAN------FVSA----ITT 137
            :.::..            |:.|..           |.::.|:...:||      |:..    :.:
Mouse   129 LRMLRQIKHPNSNLKLQDFLVDNETFSGFLQHNLSLPRSTVDSLLQANVGLQKVFLQGYQLHLAS 193

  Fly   138 LITSDRF-DIIRSNISEIISL-------VPEIERRMNYSFDI----------------------- 171
            |....:. :||:...:|:.:|       :...||.:.|:.||                       
Mouse   194 LCNGSKLEEIIQLGDAEVSALCGLPRKKLDAAERVLRYNMDILKPVVTKLNSTSHLPTQHLAEAT 258

  Fly   172 -----------KHLFSNR----------------------ETFVKLGVLLCGHPFPNTDTIPLVN 203
                       :.|||.:                      :.:..:..::||||......|..:|
Mouse   259 TVLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLN 323

  Fly   204 EILESEDFSQ---ANDAEIDAMPTRRRRRYEDLPT--DWRPTKYCKRLYRDVTSTNQGKLTWNTI 263
             ..|..::..   .|:.|            ||:.|  |...|.||..|.:::.|:...::.|..:
Mouse   324 -WYEDNNYKALFGGNNTE------------EDVDTFYDNSTTPYCNDLMKNLESSPLSRIIWKAL 375

  Fly   264 KPIIQGRILYTPANAMTESVVKFSNASFEELDRLKQL-----------------SRAAATILTKL 311
            ||::.|:|||||....|..|:...|.:|:||.....|                 |:....:.|.|
Mouse   376 KPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQIWTFMENSQEMDLVRTLL 440

  Fly   312 HT--NATFQE---------AFDNLLKLAKSPL-VKSLVGDDFDIGEIERVFEYIRTNQLIYDILT 364
            .:  |..|.|         |.|.:..|||:|. |:|..|..:...|     .:..|||.|    .
Mouse   441 DSRGNDQFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWRE-----AFNETNQAI----Q 496

  Fly   365 TVADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLA-----ALNLEDVGL-KQASYRLHMDTD 423
            |::..|:||:.::.|.:.:...|..::.||...:.|.|     .:..:.|.| ....|::.||.|
Mouse   497 TISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDID 561

  Fly   424 NTQPTFENRNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRS 487
            |.:.|.:.::.:|.|||......|::| ..||..|:.:|:..||:                    
Mouse   562 NVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIR-------------------- 606

  Fly   488 LSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRV 552
                                                                             
Mouse   607 ----------------------------------------------------------------- 606

  Fly   553 TTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPA 617
                 |::|.              .|:.|:                          |.:|.|||.
Mouse   607 -----VLTGS--------------EKKTGV--------------------------YVQQMPYPC 626

  Fly   618 FLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMS 682
            :::|:|.|  .:::.:.:...|..:..||:.::..::.:|:|....||.|||.......:|.:.|
Mouse   627 YVDDIFLR--VMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSS 689

  Fly   683 FLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLF 747
            .:.|.|...|:..:|..|.:|.|::...:..:...|.:..|..|::.:..|:.||:.|....:::
Mouse   690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIY 754

  Fly   748 FISLCPFIIVLMFD----AKLSVFESFLVDLSF-----------TTAFAKGWGELIRMELQQEGL 797
            |....|:::.:.:.    ..:.:|.|.|..::|           .......|..|....::::|.
Mouse   755 FTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGF 819

  Fly   798 TVRHLIQVGPARSECAMALLMFLLDLLLYAVI------------GLAYQRY-KKTDNYSFVKVSR 849
            .:             ..|:.|.|.|..||.|:            |:....| ..|.:|.|    .
Mouse   820 NL-------------TTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWF----G 867

  Fly   850 SQLDGK-----------------------LGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLL 889
            .::|.|                       ||.|:.|:.|:|  |.|.||..|:|:|...|::..|
Mouse   868 EEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFL 932

  Fly   890 GRNGAGKSTLIKLLTGQIRQSSGKVLLAGE----------HQVGVCWQDNILIPTLTAREHLQLY 944
            |.|||||:|.:.:|||....:||...:.|:          ..:|||.|.|:|...||..||:..|
Mouse   933 GHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFY 997

  Fly   945 AQIKIPPGGSGGVEE--IRSEVAQTLQSLNFG----KHESYPSWQLSGGYRRRLCVAIAFIASPS 1003
            |::|       |:.|  :::|:.|  .:|:.|    |.:|..| |||||.:|:|.||:||:....
Mouse   998 ARLK-------GLSEKHVKAEMEQ--MALDVGLPPSKLKSKTS-QLSGGMQRKLSVALAFVGGSK 1052

  Fly  1004 VVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDS 1068
            |||||||..|||..:|:.||:|:.:.||||.:|.:||.||||..|.|.:.|:.:|::....|...
Mouse  1053 VVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLF 1117

  Fly  1069 LQRLCTSNYSIRL----------RCADATGVTFVIQK-----------------AQQLLPQTQVT 1106
            |:....:.|.:.|          .|.:::.....::|                 .|:|:..||..
Mouse  1118 LKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKVVPGLPAAGQSGGRGGEVQRLVALTQDV 1182

  Fly  1107 ---------HSGAA----DYPHSLTINASYAEHLTPGAVEFLELLQ----------------SQV 1142
                     |...|    |..|.||....| |....||  |:||..                |:.
Mouse  1183 SAISNLIRKHVSEARLVEDIGHELTYVLPY-EAAKEGA--FVELFHEIDDRLSDLGISSYGISET 1244

  Fly  1143 TAGSI-------SDVELTTS-----------------SSLE--QEFEQLNRNGEDAGPRRPASDR 1181
            |...|       |.|:..||                 |.|.  .|.:.::.|..|..|....:|.
Mouse  1245 TLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDL 1309

  Fly  1182 SGVVAGPA-------MITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAM---- 1235
            ...:.|..       .:|.:      ||..|:.|||....|:.:.....::|||:|...|:    
Mouse  1310 LSGMDGKGSYQLKGWKLTQQ------QFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSL 1368

  Fly  1236 ---------------W-------FVSYRLEDDFD------------------------------- 1247
                           |       |||....:|..                               
Mouse  1369 IVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLA 1433

  Fly  1248 -----TVLPLSRSLY----------------------------------------PQ----TAQF 1263
                 |:.|:.:|:.                                        ||    ||..
Mouse  1434 GEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADI 1498

  Fly  1264 LSHERATSFSE---KLYPQLRTSCDHLGECRVFNTSQQSYDWVLNSWGEYSERRYGGYGLNGSGA 1325
            |.:....:.|:   |.|.|            :...|.::..||       :|.||||:.|..|.:
Mouse  1499 LQNLTGRNISDYLVKTYVQ------------IIAKSLKNKIWV-------NEFRYGGFSLGVSNS 1544

  Fly  1326 ------------------------------------------------TVWYNNKGYHSMMAWLN 1342
                                                            .||:||||:|::.::||
Mouse  1545 QALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLN 1609

  Fly  1343 DLNSELLRTTM----NDSESSILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASG 1403
            .:|:.:||..:    |.|:..|...|.|..|...:||..:::..:.|..:...::.|...|.||.
Mouse  1610 VINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASF 1674

  Fly  1404 SVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVG 1468
            .|:|:.|||:..|..|.:.||..|.|||...|||....|:...:.:::.:.|....:|....|..
Mouse  1675 VVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPV 1739

  Fly  1469 IIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRH 1533
            :..|.|.:.::..|.::.|..:|...|.|.|.:...||.:.:.......:|.:..:... :|...
Mouse  1740 LALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKL-NDIND 1803

  Fly  1534 ALNQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALII 1598
            .|...|||||...||.|.:::.||..:|....|:..:.:..||:.||:||:..|:.:.||...:|
Mouse  1804 ILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLI 1868

  Fly  1599 NVLIEWHLLRRLWQRVERLL------DCTYRRE----LDKLGQLKLVNIQSIFKSCVDTGEAVRA 1653
            .|||::....|. :.|:..|      |...|||    ||..||..::.|:.:.|           
Mouse  1869 TVLIQYRFFIRP-RPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTK----------- 1921

  Fly  1654 ENLWLAYRRGHY-AVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFEQPGI-- 1715
                 .|||... ||..:...:..||||||||.|||||||.||:|||......|..:..:..|  
Mouse  1922 -----IYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILS 1981

  Fly  1716 ---------SYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRN 1769
                     .||||.:.:..|||..|.:.|:..|||:  :::.:..:..:....|..|.:....|
Mouse  1982 NIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASN 2046

  Fly  1770 LSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEH 1834
            .||||:|||:.|:...|..|.|.:||||:.|||..|..::.....::...|:|||||||:.|.|.
Mouse  2047 YSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEA 2111

  Fly  1835 LCQRVAVLRAGQVIASDSPQRLKSEHG-GYYAVTCFCG------PAQQAILSRSLNQRLPGARDL 1892
            ||.|:|::..|:.....|.|.||:..| ||..|....|      |.|:     ......||:...
Mouse  2112 LCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQE-----FFGLAFPGSVLK 2171

  Fly  1893 QHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCD--VCVNVARFSLSRCRFETVFERIL-DSSES 1954
            :.:.:.|::    :.|.||..   |:.:|:||..  ..:::..:|:|:...:.||.... |.|:.
Mouse  2172 EKHRNMLQY----QLPSSLSS---LARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDD 2229

  Fly  1955 NGSN--GVHKDQ 1964
            :...  .:||:|
Mouse  2230 DHLKDLSLHKNQ 2241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 31/138 (22%)
ABC_subfamily_A 859..1073 CDD:213230 90/231 (39%)
drrA 865..1162 CDD:130256 118/396 (30%)
ABC2_membrane_3 1230..1601 CDD:289468 109/531 (21%)
Mem_trans 1436..>1552 CDD:304621 27/115 (23%)
ABC_subfamily_A 1651..1857 CDD:213230 78/219 (36%)
drrA 1666..1945 CDD:130256 96/300 (32%)
Abca1XP_006537617.1 rim_protein 6..2238 CDD:130324 564/2477 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 135 1.000 Domainoid score I4950
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

Return to query results.
Submit another query.