DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34120 and ABCA8

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:NP_001275914.1 Gene:ABCA8 / 10351 HGNCID:38 Length:1621 Species:Homo sapiens


Alignment Length:1541 Identity:350/1541 - (22%)
Similarity:603/1541 - (39%) Gaps:343/1541 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   637 YLLGLVV-------FVALSV-RERIWMRESRNSMLMRSMGLKAHSELVAWALM--SFLELCVIF- 690
            ||...::       :.:::| |||     .|...||..|||:..:..::|.|:  .|:.:..:| 
Human   225 YLFSCIISFSSFIYYASVNVTRER-----KRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFL 284

  Fly   691 ALI----SGVLYSGGILGYTNWFFMMFYC--LSFGLCLISFCYMCTNFFNSANIGAVASALLFFI 749
            ||:    ..::.||         ||:.:.  |.:||.|::..::.:.....:          |..
Human   285 ALVIRSTQFIILSG---------FMVVFSLFLLYGLSLVALAFLMSILVKKS----------FLT 330

  Fly   750 SLCPFIIVLMFDA--------KLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVG 806
            .|..|::.:.:..        .|.....:::.|....||..|..:|:.::.........|     
Human   331 GLVVFLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPH----- 390

  Fly   807 PARSECAMALLMFLL--DLLLYAVIGLAYQRY-----------------------KKTDN----- 841
            |:.....:....|:|  |..||..:.:.:::.                       :|||:     
Human   391 PSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALED 455

  Fly   842 --------YSFVKVSRSQLDGKLGASLVNVSKLYGSKC----AVSNLSLDFARNQVSCLLGRNGA 894
                    :...:.:..:..||....:.||:|.|..|.    |:.:|..|....|::.:||.:||
Human   456 EMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGA 520

  Fly   895 GKSTLIKLLTGQIRQSSGKVLLAG------------EHQVGVCWQDNILIPTLTAREHLQLYAQI 947
            |||||:.:|:|....:.|.|.:..            ....|||.|.|:....||.||:|:|:|:|
Human   521 GKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKI 585

  Fly   948 KIPPGGSGGV--EEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEP 1010
            |       |:  :|:..|:.:.|..|.....:...:..||||.:|:|...||.:..|.:.:||||
Human   586 K-------GILPQEVDKEIQRVLLELEMKNIQDVLAQNLSGGQKRKLTFGIAILGDPQIFLLDEP 643

  Fly  1011 CNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTS 1075
            ..|:|..:|..:|.|::..:..|.::|:|.|||||..|:|..|.:..|::....|...|::....
Human   644 TAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGI 708

  Fly  1076 NYSIRLRCADATGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTIN-------------------- 1120
            .|.:.|:..:......:....:|.:|..:::........::|.:.                    
Human   709 GYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGI 773

  Fly  1121 ASYAEHLTPGAVEFLEL------------LQSQVTAGSISDVELTTSSSLEQEFEQLNRNGEDAG 1173
            .:|...:|.....||:|            :..:|.|....|.|...  .:||....||:..:..|
Human   774 ENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLV--EMEQVLSSLNKMRKTIG 836

  Fly  1174 PRRPASDRSGVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLL---LPALFE--LC 1233
                     ||......|     .|..:.|||   :|:|..:....||.:|:   .|.|.|  :.
Human   837 ---------GVALWRQQI-----CAIARVRLL---KLKHERKALLALLLILMAGFCPLLVEYTMV 884

  Fly  1234 AMWFVSYRLEDDFDTVLPLSRSLY----------PQTAQFLSHERATSFSEKLYPQLRTSCDHLG 1288
            .::..||..|        ||..||          |.|...:.::...|..:.:     .|.:|..
Human   885 KIYQNSYTWE--------LSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFI-----QSVEHQN 936

  Fly  1289 ---ECRVFNTSQQSYDWVLNSWGEYSERRYGGYGLNGSGATVWYNNKGYHSMMAWLNDLNSELLR 1350
               |...|.|...:.|           ..|.|      ..||..|.|.|...:|    .|::.|.
Human   937 IALEVDAFGTRNGTDD-----------PSYNG------AITVCCNEKNYSFSLA----CNAKRLN 980

  Fly  1351 ---TTMNDSESSILTLNEPWKLGFAELST--SSILRQAGDGSMVFILLIAFGLVVASG-----SV 1405
               ..|:...:.:|.:.:|    ...:.|  |:.|....|..:.|:..|.|.||:.|.     ::
Human   981 CFPVLMDIVSNGLLGMVKP----SVHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAM 1041

  Fly  1406 YLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGII 1470
            ..:::..|..:.|.|:.|:|...||....:.|   :.|..:|.:.:.||..:..|.|  .|:.||
Human  1042 SSIDDYKNRARSQLRISGLSPSAYWFGQALVD---VSLYFLVFVFIYLMSYISNFED--MLLTII 1101

  Fly  1471 GL-----SLAFSFACVPSVHVAEKIF----SDSSI-----AIVSIF-CANLIVPLVTMGIILILG 1520
            .:     ::.:||:.:...:|...||    .:|.|     .:|::| .|.....:....|..|. 
Human  1102 HIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIF- 1165

  Fly  1521 VVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVF--RRYDIDSYKHPLASDLLGR 1583
                             .|||.|...:|..||.  .:.:.:.:|  .|.|:..:...|...|   
Human  1166 -----------------TFLIPPATMIGCLFLS--SHLLFSSLFSEERMDVQPFLVFLIPFL--- 1208

  Fly  1584 HFTALLLVGVAALIINVLIEWHLLRRLWQR----------------------------VERLLDC 1620
            ||       :..|.....:||...::..::                            :||:   
Human  1209 HF-------IIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGEDEDVQMERV--- 1263

  Fly  1621 TYRRELDKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGHYAVRNVNFSVQRGECFGLLGK 1685
               |..:.|..........|..||:....|.:.:..: :.|:...|.|||:|.|::||..||||.
Human  1264 ---RTANALNSTNFDEKPVIIASCLRKEYAGKRKGCF-SKRKNKIATRNVSFCVRKGEVLGLLGH 1324

  Fly  1686 NGAGKSTIFKLLTGQLQPDVGQIYFEQPG-------ISYCPQSNPLDPLLTTTECIRFYGRLRGI 1743
            |||||||..|::||..:|..||:..:..|       :.||||.|.|.|.||..:.:..|..::|:
Human  1325 NGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGL 1389

  Fly  1744 R--DLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRD 1806
            |  |.:..:.|::|..:|:......|:.||.|.:|||...::..|....||:|||::.|||..:.
Human  1390 RKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQ 1454

  Fly  1807 MVYATIEQLLL-ARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTC-F 1869
            .::..|..... ..|..:||:|.::|.|.:|.|||::.:|::....|.|.|||:.|..|.:.. .
Human  1455 QMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKV 1519

  Fly  1870 CGPAQQAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDV--CVNVA 1932
            ...||...|...:.:..|.|...:.|:..:.:.:.|.      |...|::.|..|..|  ..::.
Human  1520 KNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVE------DVQPLAQAFFKLEKVKQSFDLE 1578

  Fly  1933 RFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVAKNDLPSKSP 1978
            .:|||:...|.||   |:.|:........:|....|....||.:.|
Human  1579 EYSLSQSTLEQVF---LELSKEQELGDFEEDFDPSVKWKLLPQEEP 1621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 29/139 (21%)
ABC_subfamily_A 859..1073 CDD:213230 73/231 (32%)
drrA 865..1162 CDD:130256 87/346 (25%)
ABC2_membrane_3 1230..1601 CDD:289468 84/412 (20%)
Mem_trans 1436..>1552 CDD:304621 27/130 (21%)
ABC_subfamily_A 1651..1857 CDD:213230 73/215 (34%)
drrA 1666..1945 CDD:130256 93/291 (32%)
ABCA8NP_001275914.1 rim_protein <235..>790 CDD:130324 127/590 (22%)
ABC_subfamily_A 480..703 CDD:213230 72/229 (31%)
rim_protein <1033..1598 CDD:130324 153/615 (25%)
ABC_subfamily_A 1285..1506 CDD:213230 74/221 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148304
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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