DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34120 and ABCA7

DIOPT Version :9

Sequence 1:NP_001285513.1 Gene:CG34120 / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:XP_024307083.1 Gene:ABCA7 / 10347 HGNCID:37 Length:2151 Species:Homo sapiens


Alignment Length:2381 Identity:565/2381 - (23%)
Similarity:892/2381 - (37%) Gaps:672/2381 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPAAFSY 77
            ||.|:.:.|.||....|:.|.||:.:|.:|..:|..:...|...|.:|.:.||:.. .||.....
Human    10 LLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAG-TVPWLQGL 73

  Fly    78 ICSIENRCQP-AHPYEE---YSHWKE-------APLHSVIDVVNAFVTDERLHKAVVEL-AEKA- 129
            ||::.|.|.| ..|.||   .|::.:       |...:|:...:|..|...|.|.:..| |.:: 
Human    74 ICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARST 138

  Fly   130 ----------------NFVSAITTLITSDRFDIIRSNISE-IISLVPEIERRMNYSFDIKHLFSN 177
                            :....:|:|:.::...:......| :.||:...|........::.|...
Human   139 AQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVEL 203

  Fly   178 RETFVK----------LGVLLCGHPFPNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYED 232
            |....:          |...||....|::...|.:|....|:...........|:|         
Human   204 RALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALP--------- 259

  Fly   233 LPTDWRPTKYCKRLYRDVTSTNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEELDRL 297
               |...:..|..|...:.|....:|.|..:||:|.|::|:.|....|..::...|.:||||..|
Human   260 ---DSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLL 321

  Fly   298 KQLSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDIGEIERV------------- 349
            :.:                 :|.::.|     .|.:.:.:.|..::..::|:             
Human   322 RDV-----------------REVWEML-----GPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRP 364

  Fly   350 -----FEYIRT--------------NQLIYDILTTVADLMDCVSADRFEAVESVEELHKRAYELN 395
                 .|.:|:              :..:..::.|:..:.:|:|.|:.||..|...|..||.:|.
Human   365 GGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLL 429

  Fly   396 QNKLFLAAL--------------NLEDVGLKQASYRLHMDTDNTQPTFENRNRFWFPGPADSMVI 446
            ....|.|.:              ...|:|......::.||.|....|.:.|:|||.||||...:.
Human   430 AEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLT 494

  Fly   447 DLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFD 510
            ||:| ..|||.|:.:|                                                 
Human   495 DLRYVWGGFVYLQDLV------------------------------------------------- 510

  Fly   511 LSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLK 575
                    |:||.:|.:.|                                              
Human   511 --------ERAAVRVLSGA---------------------------------------------- 521

  Fly   576 RSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLG 640
             :.|.||                          |.:|.|||.:::|||.|  .|::.:.:...|.
Human   522 -NPRAGL--------------------------YLQQMPYPCYVDDVFLR--VLSRSLPLFLTLA 557

  Fly   641 LVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGY 705
            .:..|.|:|:..:..:|:|....||:|||......:.|.|.......:..||:..||..|.||.|
Human   558 WIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPY 622

  Fly   706 TNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESF 770
            ::...:..:..:|.:..::..::.:.||:.||:.|....|.:|....|:::.:.:..:|......
Human   623 SHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRV 687

  Fly   771 LVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSECAMALL--MFLLDLLLYAVIGLAY 833
            ...|....||..|...|..:|.|.|| ...|.:...|.....::|.:  :.|||..||   |||.
Human   688 AASLLSPVAFGFGCESLALLEEQGEG-AQWHNVGTRPTADVFSLAQVSGLLLLDAALY---GLAT 748

  Fly   834 --------QRYKKTDNYSFVKVSRS----------------QLDGKL-----------GASLVNV 863
                    .:|...:.::| ...||                .||.|:           |.|:.::
Human   749 WYLEAVCPGQYGIPEPWNF-PFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSL 812

  Fly   864 SKLY-GS-KCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGEHQV---- 922
            .|.: || :.|:..|||||.:..::..||.|||||:|.:.:|:|....|.|...:.| |.|    
Human   813 EKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILG-HDVRSSM 876

  Fly   923 -------GVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYP 980
                   |||.|.|:|...||..||:..|.::|   |.|..|  :..|..:.||.:.....:|..
Human   877 AAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLK---GLSAAV--VGPEQDRLLQDVGLVSKQSVQ 936

  Fly   981 SWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEA 1045
            :..||||.:|:|.|||||:....|||||||..|||..:|:.||:|:.:.|:||.:|.:||.:|||
Human   937 TRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEA 1001

  Fly  1046 KYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCA------------DATGVTFVIQKAQ- 1097
            :.|.|.:.::..||:....|...|:|...|.|.:.|..|            |..|.....|:.: 
Human  1002 ELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKN 1066

  Fly  1098 ----------QLLPQTQVTHSGA---ADYPHSLTINASY-AEHLTPGAVEFLE----LLQSQVTA 1144
                      |||...|....||   .:.||.|.:...| ..|....|..|.|    |.:.::|.
Human  1067 GSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTG 1131

  Fly  1145 GSISDVELTTSSSLEQEF----------------------------------------EQLNRNG 1169
            ..|||      :|||:.|                                        |....||
Human  1132 YGISD------TSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENG 1190

  Fly  1170 EDAGPRRPASDRS------GVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPA 1228
            |.|| ..|.:|:.      |.|.|.|:..       :|.:.|:.||.....|:.|.|...::|||
Human  1191 EPAG-SAPETDQGSGPDAVGRVQGWALTR-------QQLQALLLKRFLLARRSRRGLFAQIVLPA 1247

  Fly  1229 LFELCAMWF-----------------------VSYRLED-------------------------- 1244
            ||...|:.|                       ||:..||                          
Human  1248 LFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQ 1312

  Fly  1245 -------------DFDTVL------------------PLSRSLYP-------------------Q 1259
                         :...||                  |.:|.|.|                   :
Human  1313 HSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGE 1377

  Fly  1260 TAQFLSHERATSFSEKLYPQLRTSCDHLGECRVFNTSQQSYDWVLNSWGEYSERRYGGYGLNG-- 1322
            ..|.|:....:.|..|.||            |:.....::..||       :|.||||:.|.|  
Human  1378 VVQNLTGRNLSDFLVKTYP------------RLVRQGLKTKKWV-------NEVRYGGFSLGGRD 1423

  Fly  1323 ------------------------SGA---------------------TVWYNNKGYHSMMAWLN 1342
                                    .||                     .:|:||||:|||:|::|
Human  1424 PGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVN 1488

  Fly  1343 DLNSELLRTTMNDSES----SILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASG 1403
            ..::.:||..:....:    ||.|||.|..|...:||..:::..:.|..:...::.|...|.||.
Human  1489 RASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASF 1553

  Fly  1404 SVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWD---YLVMVLGLIVCLVVI--LMFGMPVFVDR 1463
            ::.|:.|||...|..|.:.|:|...|||...:||   |||.     .|:||:  |.|....:|..
Human  1554 TLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVP-----ACIVVLIFLAFQQRAYVAP 1613

  Fly  1464 QQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAW 1528
            ..|..::.|.|.:.::..|.::.|...||..|.|.|.:.|.||.:.:.......:|.:..|....
Human  1614 ANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQ 1678

  Fly  1529 DDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGV 1593
            :..| .|.|.|||||...||.|.:::.:|..:|..|.|.....::.||..:::|::..|:::.|.
Human  1679 EVSR-ILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGP 1742

  Fly  1594 AALIINVLIEWHLLRRLWQ------RVERL-----LDCTYRRELDKLGQLKLVNIQSIFKSCVDT 1647
            ..|:..:|:: |..:.|.|      ||..|     .|....||.:::.|            ....
Human  1743 LFLLFTLLLQ-HRSQLLPQYSVPRPRVRSLPLLGEEDEDVARERERVVQ------------GATQ 1794

  Fly  1648 GEAVRAENLWLAYRRGHY-AVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYF- 1710
            |:.:...||...||.... ||..:...:..||||||||.|||||::.|:::||......|:... 
Human  1795 GDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLA 1859

  Fly  1711 -----EQP-----GISYCPQSNPLDPLLTTTECIRFYGRLRGIRD---------------LDQFL 1750
                 .:|     .:.|||||:.:..|||..|.:....||||:.:               |..:.
Human  1860 GHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYA 1924

  Fly  1751 DRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQL 1815
            ||...||             ||||:|||..|:...|....|.:||||:.|||..|..::.::..:
Human  1925 DRPAGTY-------------SGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAV 1976

  Fly  1816 LLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSR 1880
            :...|:|:|||||:.|.|.||.|:|::..|:.....|||.||......:.:|.....|:....:.
Human  1977 VREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAA 2041

  Fly  1881 SLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDVCVN-----VARFSLSRCR 1940
            .:....|||...:.:...|||.:   .||.   ...|:.:|.   ::.|:     |..||:|:..
Human  2042 FVAAEFPGAELREAHGGRLRFQL---PPGG---RCALARVFG---ELAVHGAEHGVEDFSVSQTM 2097

  Fly  1941 FETVFERILDSSESNGSNGVHKDQQQQVAKNDLPSKSPAVG 1981
            .|.||   |..|:..|     ||:..:..|.......||.|
Human  2098 LEEVF---LYFSKDQG-----KDEDTEEQKEAGVGVDPAPG 2130

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34120NP_001285513.1 ABC2_membrane_3 <621..760 CDD:289468 35/138 (25%)
ABC_subfamily_A 859..1073 CDD:213230 85/226 (38%)
drrA 865..1162 CDD:130256 113/340 (33%)
ABC2_membrane_3 1230..1601 CDD:289468 115/525 (22%)
Mem_trans 1436..>1552 CDD:304621 37/120 (31%)
ABC_subfamily_A 1651..1857 CDD:213230 77/232 (33%)
drrA 1666..1945 CDD:130256 93/309 (30%)
ABCA7XP_024307083.1 rim_protein 1..2114 CDD:130324 561/2363 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148320
Domainoid 1 1.000 134 1.000 Domainoid score I5010
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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